Lect. 5 Host Pathogen interaction-II
Lect. 5 Host Pathogen interaction-II
Lect. 5 Host Pathogen interaction-II
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GUARD HYPOTHESIS<br />
Vander Biezen and Jones, 1998<br />
• lack of evidence for a direct <strong>interaction</strong><br />
indicated the involvement of some other type<br />
of <strong>interaction</strong> between the R gene and Avr<br />
gene products and led to the formation of the<br />
guard hypothesis.<br />
• This model proposes that the R proteins<br />
interact, or guard, a protein known as the<br />
guardee, which is the target of the Avr protein.<br />
When it detects interference with the guardee<br />
protein, it activates resistance.
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