DNA copy numbers and the Circular Binary Segmentation Algorithm
DNA copy numbers and the Circular Binary Segmentation Algorithm
DNA copy numbers and the Circular Binary Segmentation Algorithm
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CBS More on CBS Methods<br />
• Recursively split <strong>the</strong> data if p-value below threshold<br />
• Tail probability approximation for Normal data<br />
– Siegmund (1988); Yao (1989)<br />
• Calculate reference distribution by permuting<br />
• If ternary split, <strong>the</strong> first <strong>and</strong> third segment are tested for<br />
a binary split with <strong>the</strong> middle segment (edge effect)<br />
• <strong>Algorithm</strong>ic tweaks:<br />
* Maximize difference in means for fixed segment length<br />
* Stop permutations once p-value exceeds threshold<br />
* Moving windows for large data sets (deprecated)<br />
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