DNA copy numbers and the Circular Binary Segmentation Algorithm
DNA copy numbers and the Circular Binary Segmentation Algorithm
DNA copy numbers and the Circular Binary Segmentation Algorithm
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CBS Hybrid p-value Faster CBS<br />
Test statistic T = max{T 1 , T 2 } where<br />
T 1 = max<br />
A 1<br />
|T ij | <strong>and</strong> T 2 = max<br />
A 2<br />
|T ij |<br />
A 1 = {i, j : j − i ≤ k or > n − k} (small arcs)<br />
A 2 = {i, j : k + 1 ≤ j − i ≤ n − k} (non-small arcs)<br />
Choose k to call an arc small<br />
Split data if P (T > T obs ) < α<br />
Bound P (T > T obs ) ≤ P (T 1 > T obs ) + P (T 2 > T obs )<br />
Use permutation for P (T 1 > T obs ) <strong>and</strong><br />
Approximate P (T 2 > T obs ) (Siegmund (1988), Yao (1993))<br />
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