DNA copy numbers and the Circular Binary Segmentation Algorithm

CBS Multi platform data wCBS
• Method to merge data from multiple platforms
• Platform specific probe noise - weights w i
• Partial sums: S i = w 1 Z 1 + · · · + w i Z i ,
W i = w 1 + · · · + w i
i = 1, . . . , n
• Test statistic: T =
max
1 ≤ i < j ≤ N
|T ij |, where
T ij =
⌢
Z ij − ⌣ Z ij
s
√(W j − W i ) −1 + (W i + W n − W j ) −1,
⌢
Z ij = (S j − S i )/(W j − W i )
and
⌣
Z ij = {S i + (S n − S j )}/(W i + W n − W j )
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