DNA copy numbers and the Circular Binary Segmentation Algorithm

More documents

Recommendations

Info

CBS Lung project Example • Two broad categories of lung cancer: small cell (SCLC) and non-small cell (NSCLC) • Adenocarcinoma is a histological subtype of NSCLC • Recent advance: EGFR mutation and effective TKI drugs • Prognosis is in general poor especially KRAS mutation Can we learn more by profiling DNA copy number? ≈ 250 samples using Agilent 44k arrays. Also gene expressions using Affy U133 arrays 21
CBS Lung Project Example 22
Page 1 and 2: DNA copy numbers and the Circular B
Page 3 and 4: CBS Background Comparative genomic
Page 5 and 6: CBS Example Lung cancer BAC array w
Page 7 and 8: CBS Analysis Overall plan In sample
Page 9 and 10: CBS Change-points Methods Let Z 1 ,
Page 11 and 12: CBS Binary Segmentation Fails Metho
Page 13 and 14: CBS Circular Binary Segmentation Me
Page 15 and 16: CBS More on CBS Example −2 −1 0
Page 17 and 18: CBS Hybrid p-value Faster CBS Test
Page 19 and 20: CBS Stopping rule Faster CBS • da
Page 21: CBS Performance gain Faster CBS 100
Page 25 and 26: CBS Lung Project Example 24
Page 27 and 28: CBS Lung Project Example -./0123" &
Page 29 and 30: CBS Copy Number Variation TCGA 28
Page 31 and 32: CBS Multi platform data wCBS Weight
Page 33 and 34: CBS MIPs Example ASCN Allele A copy
Page 35 and 36: CBS Allele A vs B ASCN Homozygotes
Page 37 and 38: CBS Allele A vs B ASCN Step 3: Test
Page 39 and 40: CBS Reconstruction ASCN Allele A co
Page 41 and 42: CBS Equality of parental CN ASCN Ch
Page 43 and 44: CBS References 1. Autio, R. et al.

DNA copy numbers and the Circular Binary Segmentation Algorithm

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?