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Protocol for Establishing and Maintaining the Calibration - NPL ...

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FOREWORD<br />

This Good Practice Guide describes <strong>the</strong> use of radionuclide calibrators <strong>for</strong> <strong>the</strong> measurement<br />

of radionuclides used in medical practice <strong>and</strong> how all measurements made using <strong>the</strong>se<br />

systems can be traced to primary measurement st<strong>and</strong>ards held at <strong>the</strong> National Physical<br />

Laboratory (<strong>NPL</strong>). Accurate measurements <strong>and</strong> <strong>the</strong>ir traceability to primary st<strong>and</strong>ards<br />

toge<strong>the</strong>r with a documented quality assurance programme are requirements of both <strong>the</strong><br />

Ionising Radiation Regulations, 1999[1] <strong>and</strong> <strong>the</strong> Ionising Radiations (Medical Exposures)<br />

Regulations, 2000 [2].<br />

In 1992, <strong>the</strong> Institute of Physical Sciences in Medicine (IPSM) addressed <strong>the</strong> issue of Quality<br />

St<strong>and</strong>ards in Nuclear Medicine <strong>and</strong> published <strong>the</strong>ir recommendations in IPSM Report No. 65,<br />

Chapter 5 [3]. This section of <strong>the</strong> report was produced by a joint Working Group, comprising<br />

members of IPSM <strong>and</strong> <strong>NPL</strong>, which dealt specifically with <strong>the</strong> establishment <strong>and</strong> maintenance<br />

of <strong>the</strong> calibration of medical radionuclide calibrators <strong>and</strong> <strong>the</strong>ir quality control. Since <strong>the</strong>n,<br />

new measurement needs have arisen <strong>and</strong> commercially available calibrators have been<br />

improved <strong>and</strong> upgraded. It was agreed that <strong>the</strong> original recommendations should be revised<br />

<strong>and</strong> updated accordingly.<br />

The Institute of Physics <strong>and</strong> Engineering in Medicine (IPEM) <strong>and</strong> <strong>the</strong> <strong>NPL</strong> established a<br />

fur<strong>the</strong>r Working Group in 2001 to revise <strong>the</strong> existing guidelines <strong>and</strong> to produce a good<br />

practice guide <strong>for</strong> users of radionuclide calibrators in hospitals. The recommended<br />

procedures are intended <strong>for</strong> use in busy hospital departments <strong>and</strong> should not add appreciably<br />

to <strong>the</strong> existing workload. The emphasis has continued to be simple, robust <strong>and</strong> reliable<br />

procedures.<br />

The revision comprises two chapters. Chapter 1 includes most of <strong>the</strong> existing procedures<br />

whilst Chapter 2 provides more detailed descriptions of, <strong>and</strong> justifications <strong>for</strong>, <strong>the</strong> procedures<br />

toge<strong>the</strong>r with relevant examples of possible sources of error <strong>and</strong> <strong>the</strong> typical uncertainties<br />

associated with <strong>the</strong>m.

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