Protocol for Establishing and Maintaining the Calibration - NPL ...
Protocol for Establishing and Maintaining the Calibration - NPL ...
Protocol for Establishing and Maintaining the Calibration - NPL ...
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FOREWORD<br />
This Good Practice Guide describes <strong>the</strong> use of radionuclide calibrators <strong>for</strong> <strong>the</strong> measurement<br />
of radionuclides used in medical practice <strong>and</strong> how all measurements made using <strong>the</strong>se<br />
systems can be traced to primary measurement st<strong>and</strong>ards held at <strong>the</strong> National Physical<br />
Laboratory (<strong>NPL</strong>). Accurate measurements <strong>and</strong> <strong>the</strong>ir traceability to primary st<strong>and</strong>ards<br />
toge<strong>the</strong>r with a documented quality assurance programme are requirements of both <strong>the</strong><br />
Ionising Radiation Regulations, 1999[1] <strong>and</strong> <strong>the</strong> Ionising Radiations (Medical Exposures)<br />
Regulations, 2000 [2].<br />
In 1992, <strong>the</strong> Institute of Physical Sciences in Medicine (IPSM) addressed <strong>the</strong> issue of Quality<br />
St<strong>and</strong>ards in Nuclear Medicine <strong>and</strong> published <strong>the</strong>ir recommendations in IPSM Report No. 65,<br />
Chapter 5 [3]. This section of <strong>the</strong> report was produced by a joint Working Group, comprising<br />
members of IPSM <strong>and</strong> <strong>NPL</strong>, which dealt specifically with <strong>the</strong> establishment <strong>and</strong> maintenance<br />
of <strong>the</strong> calibration of medical radionuclide calibrators <strong>and</strong> <strong>the</strong>ir quality control. Since <strong>the</strong>n,<br />
new measurement needs have arisen <strong>and</strong> commercially available calibrators have been<br />
improved <strong>and</strong> upgraded. It was agreed that <strong>the</strong> original recommendations should be revised<br />
<strong>and</strong> updated accordingly.<br />
The Institute of Physics <strong>and</strong> Engineering in Medicine (IPEM) <strong>and</strong> <strong>the</strong> <strong>NPL</strong> established a<br />
fur<strong>the</strong>r Working Group in 2001 to revise <strong>the</strong> existing guidelines <strong>and</strong> to produce a good<br />
practice guide <strong>for</strong> users of radionuclide calibrators in hospitals. The recommended<br />
procedures are intended <strong>for</strong> use in busy hospital departments <strong>and</strong> should not add appreciably<br />
to <strong>the</strong> existing workload. The emphasis has continued to be simple, robust <strong>and</strong> reliable<br />
procedures.<br />
The revision comprises two chapters. Chapter 1 includes most of <strong>the</strong> existing procedures<br />
whilst Chapter 2 provides more detailed descriptions of, <strong>and</strong> justifications <strong>for</strong>, <strong>the</strong> procedures<br />
toge<strong>the</strong>r with relevant examples of possible sources of error <strong>and</strong> <strong>the</strong> typical uncertainties<br />
associated with <strong>the</strong>m.