Powering the Future - 立命館大学

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Ritsumeikan University College of Pharmaceutical Sciences Medical Pharmacy Division Research/Development Areas Construction of the Estimation System for Pharmacokinetic Properties of New Chemical Entities Professor / Takuya FUJITA, Assistant Professor / Yuka MORIYA At present new chemical entities, which have been synthesized and screened on the basis of genomics and/or proteomics, have been suggested to exhibit unfavorable pharmacokinetic behavior as drugs due to their large molecular weight and/or high lipohilicity. The in vivo pharmacokinetic properties of drugs are determined by their absorption (A), distribution (D), metabolism (M), elimination (E) and toxicity (Tox). However the molecular mechanisms for their pharmacokinetic properties are extremely complex and have yet to been sufficiently elucidated. We focus various kinds of carrier proteins (transporters), which are expressed in the intestine and the central nervous system in ADME-Tox research, and attempt to elucidate their roles in the intestinal absorption of drugs and the expression of their pharmacologic effects. ■Activated glial cells Research/Development Areas Clinical Pharmaceutical Sciences for Rational Use of Drugs and Optimization of Pharmacotherapy Professor / Nobuhiro ICHIKAWA, Tomonobu OKANO, Associate Professor / Mikio KAKUMOTO, Assistant Professor / Naoki TOMIYAMA With the recent specialization of and advances made in medicine the demand for scientific nature has grown in drug therapy. Predicting quantitatively for each patient the effects, side effects and so forth that can occur when a drug is used is important in implementing practical rational drug therapy. This laboratory is involved in the proper use of drugs through studying the clinical pharmacokinetics as well as their optimal administration methods etc for use in more effective management of drug treatments. We are also attempting to elucidate the mechanism of drug interactions and their side effects in revealing a drug administration method that will minimize any adverse reactions. Furthermore, we are also collecting information on drug efficacy and side effects etc and studying ways of evaluating, processing, reconstructing and transmitting the obtained information, including analysis, in conformance with Evidence Based Medicine (EBM) to optimize drug therapy. ■Investigation for Proper Use of Probiotics using a Clostridium butyricum preparation Research/Development Areas Regulatory Roles of Natural Antisense Transcripts of IFNA1 Gene Professor / Tominori KIMURA The discovery was made that mRNA, which had been conventionally thought to reach the cytoplasm through passive diffusion, is actually actively transported through the recognition of a transport signal by receptors when CRM1 was discovered as the transport receptor for human immunodeficiency virus type I (HIV-1) RNA at the end of the 1990s. This discovery of a nuclear export mechanism for mRNA enabled the research field of post-transcriptional regulation of gene expression after gene transcriptions to dramatically grow. Under the spotlight recently within those studies is the transcription products from antisense strands confirmed to exist in 70% or more of mammal genes, and we are interested in their function as regulatory RNA. This laboratory aims to elucidate virus growth regulatory and the protective mechanism of living bodies through researching that post-transcriptional regulation of gene expression mechanism. ■Antisense RNA roles on the viral and host gene expression 61 Ritsumeikan University Powering the Future
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Powering the Future - 立命館大学

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