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σ70 binds both the –35 and –10 sequences.<br />

The crystal structure of a sigma factor fragment from the<br />

bacterium Thermus aquaticus shows that these regions fold into<br />

three independent domains in the protein:<br />

domain σ2 contains 1.2-2.4, σ3 contains 3.0-1.3, and σ4 contains<br />

4.1-4.2<br />

B-22

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