Transcription

Bacterial RNA Polymerase
•The RNA polymerase holoenzyme (complete enzyme) is the form that
is competent to initiate transcription. It consists of the four subunits of
the core enzyme, α2ββ′ (~465 kda) and sigma factor.
The β and β′ subunits contact DNA at
many points downstream of the active
site. They make several contacts with
the coding strand in the region of the
transcription bubble, thus stabilizing the
separated single strands.
B-7