PROGRAMME SCIENTIFIQUE - Oxygen Club of California

P58
Oxidative Stress and Gestational Diabetes
Luis Arribas, Maria Muriach, Inmaculada Almansa, Maria Miranda, Vincent M. Villar, Francisco
Bosch-Morell, Francisco J. Romero.
Universidad CEU – Cardenal Herrera. Moncada 46113 Valencia, Spain - arribaspalomar@gmail.com
The main objective of this research work was to evaluate if there was oxidative damage and the level of
that damage in gestational diabetes.
In the present study thirty-seven healthy women and thirty-seven women with gestational diabetes were
analyzed in the three trimesters of pregnancy regarding their levels of oxidative stress. These women
were diagnosed with diabetes in the second semester of pregnancy
None of the women had an acute disease or clinical complication during the pregnancy. All of them
received the same polivitaminic treatment and the same diet. There were no significant differences in
maternal age, parity and sex and body weight of the newborns.
The glucemic control which was measured by glycosylated hemoglobin was similar for both groups of
women in the first trimester, going up in the gestational diabetic group in the second and third trimester
with significant differences among them
(p < 0.001).
Regarding the mean values of MDA the group of women with gestational diabetes had all the values with
higher levels and with significant differences in the first and in the second trimester (p < 0.019 and p <
0.028 respectively). There were no significant differences within each of the groups during the gestational
period.
The mean values of GPx for the diabetic women were always lower with significant differences in the
first trimester (p< 0.001). In the group of gestational diabetes there was significant differences between
the first and the other two following trimesters.
The correlation study through Pearson's chi-square test shows that in the group of women with gestational
diabetes there is an inverse linear correlation between MDA and GPx in the second and third ( p