PROGRAMME SCIENTIFIQUE - Oxygen Club of California
PROGRAMME SCIENTIFIQUE - Oxygen Club of California
PROGRAMME SCIENTIFIQUE - Oxygen Club of California
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P26<br />
Phytoestrogens enhance antioxidant enzyme defenses and reduce testosterone and<br />
estradiol circulating levels<br />
Antonia Mestre 1 , Miguel D. Ferrer 1 , Antoni Sureda 1 , Pedro Tauler 1 , Elisa Martínez 1 , M. del Mar<br />
Bibiloni 1 , V. Micol 2 , Josep A. Tur 1 and Antoni Pons 1 .<br />
1 Laboratori de Ciències de l’Activitat Física, Departament de Biologia Fonamental i Ciències de la Salut.<br />
Grup de Nutrició Comunitaria i Estrés Oxidatiu. IUNICS. Universitat de les Illes Balears, Ctra.<br />
Valldemossa Km 7.5, E-07122 Palma de Mallorca, Illes Balears, Spain. Telephone: +34-971173171.<br />
Mail: antonipons@uib.es<br />
2 Instituto de Biología Molecular y Celular. Universidad Miguel Hernández. Elche.<br />
Our aim was to evidence the effects <strong>of</strong> diet supplementation with phytoestrogens on blood cell counts,<br />
erythrocyte antioxidant adaptive responses and sex hormone levels induced by moderate exercise. Ten<br />
female swimmers participated for 26 days in a double-blind diet intervention with either a functional<br />
beverage rich in vitamins E and C or the same beverage but also supplemented with Lippia citriodora<br />
extract (PLx). After the intervention all subjects participated in a swimming session. Supplementation<br />
with PLx induced lower leukocyte and erythrocyte circulating levels. Diet supplementation with PLx<br />
enhanced the activation <strong>of</strong> erythrocyte antioxidant enzymes in response to the swimming session. Thus,<br />
swimming increased the erythrocyte activity <strong>of</strong> glutathione peroxidase and glutathione reductase only in<br />
the PLx-supplemented group. PLx decreased the plasma levels <strong>of</strong> 17-b-estradiol, testosterone and free<br />
testosterone and increased the levels <strong>of</strong> the sex hormone binding protein. In summary, diet<br />
supplementation with phytoestrogens such as verbascoside decreases the number <strong>of</strong> circulating<br />
erythrocytes and leukocytes and enhances the glutathione-dependent enzyme activities in erythrocytes in<br />
response to exercise. Diet supplementation with verbascoside also decreases the plasma steroid hormone<br />
levels, pointing towards a possible agonist effect between estradiol and these phytoestrogens.<br />
This work was supported by a grand <strong>of</strong> Consejo Superior de Deportes (10/UPB10/08).
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