1861. Phase Only Cross-Correlation Tracking of a Passive Marker for MR-Guided Interventions Roger Jason Stafford 1 , Florian Maier 2 , Axel Joachim Krafft 2 , Michael Bock 2 , Axel Winkel 3 , Kamran Ahrar 4 1 Department of Imaging Physics, The University of Texas M. D. Anderson Cancer Center , Houston, TX, United States; 2 Department of Medical Physics in Radiology, Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany; 3 Invivo GMBH, Schwerin, Germany; 4 Department of Diagnostic Radiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, United States Real-time MR-guidance of percutaneous procedures may benefit from methods for automatically adjusting the scan prescription to the needle trajectory, as well as visual delineation of the trajectory, in real-time. In this work, the feasibility of using a phase only cross correlation tracking algorithm for automated identification of a contrast filled needle sleeve with real-time adjustment of the scan prescription for continuous delineation of the needle trajectory during manipulation was investigated in phantom and patients for MRguidance of percutaneous procedures in a closed bore 1.5T clinical scanner. 1862. Targeted Magnetic Delivery of Cells with an MRI Scanner Johannes Riegler 1,2 , Jack A. Wells 1 , Panagiotis Kyrtatos 1 , Anthony N. Price 1 , Mark F. Lythgoe 1 1 Centre for Advanced Biomedical Imaging (CABI), Department of Medicine and Institute of Child Health, University College London (UCL), London, United Kingdom; 2 Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), UCL, London, United Kingdom Targeted delivery of cells or drugs is a technique that could increase the efficacy of medical treatments. One possibility for that is using magnetic fields to drag labelled entities to the site of interest. MRI systems are particular interesing for this purpose due to their ability to generate uniform magnetic field gradients across the whole body. We demonstrated the feasibility of steering magnetically labelled cells to one exit tube of a bifurcation phantom by applying MR imaging gradients. This technique could potentially be used for localised cell delivery in the vascular system. 1863. Simultaneous Wireless Fast Scan Cyclic Voltammetry and Amperometry with 3T MRI Kendall Lee 1 , Jonathan Bledsoe 1 , Kiaran McGee 2 , John Huston 2 , Chris Kimble 3 , Filippo Agnesi, Kevin Bennet 3 , Charles Blaha 4 , Paul Garris 5 1 Department of Neurosurgery, Mayo Clinic, Rochester, MN, United States; 2 Department of Radiology, Mayo Clinic, Rochester, MN, United States; 3 Department of Engineering, Mayo Clinic, Rochester, MN, United States; 4 Department of Psychology, University of Memphis; 5 Biological Sciences, Illinois State University Electroanalytical techniques such as fast-scan cyclic votlammetry (FSCV) and constant-potential amperometry (CPA) have revolutionized neuroscience research by supporting temporally, spatially, and chemically resolved neurotransmitter measurements in the brain. CPA and FSCV were performed by a small, digital-telemetry device called a wireless instantaneous neurotransmitter concentration system (WINCS) specifically developed for neurochemical monitoring. Test measurements were collected during simultaneous 3T imaging using a fast spin echo sequence. WINCS dynamically recorded dopamine electrochemical signatures with sub-second temporal resolution and with high fidelity. We demonstrate proof-of-concept for combining WINCS real-time neurochemical measurements and 3T MRI that may offer simultaneous neurochemical monitoring during fMRI. 1864. Two Channel <strong>Interventional</strong> Cervix Coil for High Dose Rate Brachytherapy Nikolay Vladimirovic Viskusenko 1 , Emre Kopanoglu 2 , John Jezioranski 3 , Warren Foltz 3 , Oktay Algin 4 , Ergin Atalar 2 1 UMRAM: National Magnetic Resonance Research Center , Bilkent Universty Elektrical and Elektronic Engineering , Ankara , Turkey; 2 UMRAM: National Magnetic Resonance Research Center, Bilkent Universty Elektrical and Elektronic Engineering, Ankara, Turkey; 3 University Health Network, Toronto, Canada; 4 Radiology, Ataturk Hospital, Ankara, Turkey Determination of the diseased tissue region is very crucial for brachytherapy treatment. In this study, we propose a new 2-channel coil structure that is embedded on a commercially available HDRT applicator. After MRI imaging of the cervix, brachytherapy procedure can be carried out as normal without moving the applicator, which is essential for the correctness of radiation dose calculations. Invivo animal experiments have been conducted and good quality images have been obtained. 1865. Esophagus Imaging with Intraluminal RF Coil for Integrated MR-Endoscope System Yuichiro Matsuoka 1 , Hayato Yoshinaka 1 , Susumu Aizawa 2 , Makiya Matsumoto 2 , Yoshinori Morita 1 , Hiromu Kutsumi 1 , Etsuko Kumamoto 3 , Kagayaki Kuroda 4,5 , Takeshi Azuma 1 1 Graduate School of Medicine, Kobe University, Kobe, Hyogo, Japan; 2 Graduate School of Engineering, Kobe University, Kobe, Hyogo, Japan; 3 Information Science and Technology Center, Kobe University, Kobe, Hyogo, Japan; 4 Medical Device Development Center, Foundation for Biomedical Research and Innovation, Kobe, Hyogo, Japan; 5 School of Information Science and Technology, Tokai Univesity, Hiratsuka, Japan An endoscope shows an interior surface image of organ, but it has difficulty finding the information under tissue surface. To assist endoscopy and endoscopic surgery by providing cross-sectional images, we have developed an integrated MR-endoscope system. An
intraluminal RF coil to be inserted into esophagus was designed, and MR imaging using this coil and a tracking system to detect the coil position in MRI was conducted using an excised porcine tissue. The layer structure in esophagus could be distinguished in T1- and T2-weighted images. The feasibility of esophagus imaging by the developed coil having high Q value was demonstrated.
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