Traditional Posters: Interventional - ismrm

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1831. A Self-Reference MR Thermometry Method Utilizing the Phase Gradient Jason A. Langley 1,2 , Qun Zhao 1,2 1 Department of Physics and Astronomy, The University of Georgia, Athens, GA, United States; 2 Bioimaging Research Center (BIRC), The University of Georgia, Athens, GA, United States A modified self-reference MR thermometry method is presented in this abstract. We circumvent the phase unwrapping procedure in the self-reference MR thermometry procedure by utilizing the phase gradient to estimate the baseline phase map. In the method proposed in this abstract, the phase map is modeled as a 2D polynomial. The components of the gradient of the model are then fitted to the components of the phase gradient using 2D weighted least squares. The proposed procedure is evaluated using two simulated MR thermometry data sets. 1832. First Clinical Experience with Navigated RF Ablations of the Liver in a Closed-Bore 1.5T MRI Daniel Seider 1 , Harald Busse 1 , Nikita Garnov 1 , Gregor Thörmer 1 , Susann Heinig 1 , Tim Riedel 1 , Thomas Kahn 1 , Michael Moche 1 1 Diagnostic and <strong>Interventional</strong> Radiology, Leipzig University Hospital, Leipzig, Germany MRI is well suited to guide percutaneous interventions of liver lesions that are hardly visible with ultrasound or CT. Dedicated open MR systems are often used because they provide good patient access. This work presents first clinical experience with a new navigation solution that was used during RF ablation of liver tumors in a standard closed-bore scanner environment. After a special breathhold training, even double oblique access paths could be realized. RFA probe and thermally induced lesion could be reliably visualized with a VIBE sequence. While technical efforts are higher the times for needle placement and thermal ablation are comparable to those under CT guidance. 1833. Highly Accelerated Temperature Mapping Using Nonlocal Regularized Parallel Imaging Sheng Fang 1 , Xinyi Pan 1 , Kui Ying 1 1 Department of Engineering Physics, Tsinghua University, Beijing, China Model-based MR thermometry method based on the proton resonance frequency shift (PRFS) can effectively improve the temperature estimate accuracy of conventional phase different method. However, its temporal resolution need be improved for real-time temperature monitoring. To solve the problem, we applied highly accelerated PI to temperature mapping and used nonlocal regularization that extracts the prior from the acquired data themselves to stabilize the reconstruction. The method was demonstrated using whipping cream phantom. The results show that the nonlocal regularization can effectively increase the temporal resolution of PRFS while avoiding the introducing the bias to quantification, due to its data-driven property. 1834. Quantitative Analysis for Optimizing the MRI Temperature Monitoring Using Keyhole Technique Yong hee Han 1 , Kang soo Kim 1 , Dong Hyuk Kim 1 , Kwang sik Lee 2 , Jae Ryang Juhn 3 , Choong ki Eun 3 , Chi woong Mun 1,4 1 Bio medical engineering, Inje University, Gimhae, Gyeongsangnam-do, Korea, Republic of; 2 Medical Image Science, Pusan Paik hospital, Korea, Republic of; 3 Diagnostic of Radiology Medical School, Pusan Paik hospital, Korea, Republic of; 4 Medical Image Research Center, Inje University, Korea, Republic of This study proposes the keyhole method in order to improve the time resolution of the proton resonance frequency (PRF) MR temperature monitoring technique. To evaluate proposed method, the values of Root Mean Square (RMS) error were compared with full phase encoded temperature images. And the paired t-test was performed for optimization at Keyhole technique. As a result of this study, >32 encoded images were reasonable in 95% confidence level whereas
1836. Gd-Labelled Polylysine as a Tracer for Convective Enhanced Delivery Peter Andrew Hardy 1 , Luke H. Bradley 1 , Zhiming Zhang 1 , Don Gash 1 , Dan Keeley 2 , Brian Kramer 3 , Greg Schorn 4 1 Anatomy & Neurobiology, University of Kentucky, Lexington, KY, United States; 2 Advanced Technologies and Regenerative Medicine, Rayntham, MA, United States; 3 Advanced Technologies and Regenerative Medicine, Somerville, NJ, United States; 4 Advanced Technologies and Regenerative Medicine, Rayntham, Massachussets, United States Convection Enhanced Delivery is a powerful method of delivering drugs to the CNS. MR-visible tracers co-infused with drug will be useful to assess drug distribution. We tested four compounds (Magnevist and three Gd-labeled polylysines) with molecular weights between 0.5k Da and 200 kDa as potential tracers for CED. Compounds were tested in vitro to model CED parameters used to plan delivery into four rhesus monkeys. In vitro results demonstrated MW dependent CED distribution. In vivo results demonstrated distribution of the Magnevist in the putamen but little distribution of the polylysine as a result of binding and digestion of the polylysine. Clinical & Pre-clinical Interventions (Non-thermal) Hall B Thursday 13:30-15:30 1837. Novel Delivery System for Minimally Invasive MR Guided Neurological Interventions Alastair Martin 1 , Mark Richardson 2 , Adrian Kells 2 , John Bringas 2 , Pete Piferi 3 , Lisa Tansey 3 , Geoffrey Bates 3 , Philip Starr 2 , Paul Larson 2 , Krystof Bankiewicz 2 1 Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, CA, United States; 2 Neurological Surgery, University of California - San Francisco; 3 SurgiVision, Inc, Irvine, CA A novel delivery system for MR guided precision minimally invasive access to deep brain structures is presented. A targeting accuracy of 0.5 mm at depths of 85-90mm is achieved in a phantom model. The delivery system is also used to insert cannula’s for infusing therapeutic agents via convection-enhanced delivery (CED). CED is demonstrated in a non-human primate with infusions to the thalamus, putamen and sub-thalamic nucleus. Accurate delivery of infusion cannula’s was achieved and CED infusions extending up to 10mm in diameter are demonstrated. 1838. Retrograde Drilling of Osteochondral Lesions of the Knee with MRI Guidance Christian Jürgen Seebauer 1 , Hermann Josef Bail 2 , Jens Christian Rump 3 , Ulf Teichgräber 3 1 Center for Musculoskeletal Surgery, Charité, Berlin, Germany; 2 Department of Trauma and Orthopedic Surgery, Clinic Nuremberg, Nuremberg, Germany; 3 Department of Radiology, Charité, Berlin, Germany Osteochondritis Dissecans (OD) of the knee is a common articular lesion in adolescents and young adults. Retrograde drilling is an alternative in surgical treatment before more invasive and complex procedures are necessary; however drilling under fluoroscopic guidance via the epiphyses is technically challenging in terms of maintaining drill depth and accuracy of drill placement. The purpose of this study was to evaluate applicability and accuracy of a passive navigation method by drilling a simulated OD target at the knee with MRI guidance. Interactive MR navigation allowed precise drilling of OCD of the knee. Targeting was possible with a single drilling. 1839. Implementation of an Interactive Real-Time MRI Acquisition and Display for Improving Efficiency and Accuracy of MR-Guided Breast Interventions Matt Smith 1 , Ethan Brodsky 1,2 , Steve Kecskemeti 1 , Xu Zhai 1 , Sean Fain 1,3 1 Medical Physics, University of Wisconsin, Madison, WI, United States; 2 Radiology, University of Wisconsin, Madison, WI, United States; 3 Biomedical Engineering, University of Wisconsin, Madison, WI, United States During an MR-guided breast intervention, placement of a needle or probe requires accurate localization of the target. To allow rapid identification of these errors, avoid unnecessary trauma to the patient, and minimize scanner time, a real-time MR acquisition and display was implemented to allow the physician to monitor both the progress of the insertion and the procedure itself, such as core needle biopsy or tumor ablation. Flexibility was added to adjust the scan plane in real-time and make tradeoffs between update display rate and image quality. 1840. A Passive, Image-Based Navigation Tool for Real-Time MR-Guided Percutaneous <strong>Interventional</strong> Procedures Wilhelm Strehl 1 , Eva Rothgang 1,2 , Wesley Gilson 2 , Klaus J. Kirchberg 3 , Joachim Hornegger 1 , Christine Lorenz 2 1 Pattern Recognition Lab, Department of Computer Science, University of Erlangen-Nuremberg, Erlangen, Bavaria, Germany; 2 Center for Applied Medical Imaging, Siemens Corporation, Corporate Research, Baltimore, MD, United States; 3 Center for Applied Medical Imaging, Siemens Corporation, Princeton, NJ, United States Percutaneous interventions involve the navigation of a needle or probe to a target location. MRI is well-suited to guide these procedures as it offers good soft tissue target visualization and no ionizing radiation. High field wide bore MRI has stimulated interest
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Traditional Posters: Interventional - ismrm

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