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Is Survival the Only Thing that Matters?

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Characteristics of Oncology Trials<br />

Phase I<br />

Phase II<br />

Phase III<br />

Number of<br />

patients<br />

20-30<br />

30-100<br />

200-5000<br />

Primary Endpoints<br />

Maximum<br />

tolerated dose<br />

Response rate<br />

Time to tumor<br />

progression<br />

<strong>Survival</strong><br />

Quality of life<br />

Time to tumor<br />

progression<br />

Cost per patient<br />

100<br />

75<br />

64<br />

Cost per phase<br />

10<br />

22<br />

100

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