Data sheet TCO-NHS ester - Jena Bioscience

Data sheet
TCO-NHS ester
Trans-Cyclooctene-NHS ester
TCO-Carbonate; (E)-Cyclooct-4-enyl-2,5-dioxo-1-pyrrolidinyl carbonate
Important Product Information
• TCO-NHS ester is not soluble in aqueous buffers.
• Not recommended for labeling biopolymers in aqueous
media due to very poor labeling efficiency.
Selected References:
Karver et al. (2012) Bioorthogonal Reaction Pairs Enable Simultaneous,
Selective, Multi-Target Imaging. Angew. Chem. Int. Ed. 51:920.
Devaraj et al. (2009) Fast and Sensitive Pre-Targeted Labeling of
Cancer Cells through a Tetrazine/trans-Cyclooctene Cycloaddition.
Angew. Chem. Int. Ed. 48:7013.
Haun et al. (2009) Probing Intracellular Biomarkers and Mediators of
Cell Activation Using Nanosensor and Bioorthogonal Chemistry. ACS
Nano. 5:3204.
Blackman et al. (2008) Tetrazine Ligation: Fast Bioconjugation Based
on Inverse-Electron-Demand Diels-Alder Reactivity. J. Am. Chem. Soc.
130:13518.
Devaraj et al. (2008) Tetrazine-Based Cycloadditions: Application to
Pretargeted Live Cell Imaging. Bioconjugate Chem. 19:2297.
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Last update: Jun 14, 2013