Mapping of Italian research excellence in Neurodegenerative - Apre

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Nome Maurizio Popoli Contatti Tel. E mail Tel: +390250318361 E-mail: maurizio.popoli@unimi.it Istituto/Dipartimento Center of Neuropharmacology, Department of Pharmacological Sciences, CEND, University of Milan Proposta di ricerca Area di interesse identificata 1A. Presynaptic molecular machinery regulating glutamate release as pathophysiological mechanism in amyotrophic lateral sclerosis Finanziamenti ricevuti Titolo progetto Ente finanziatore Durata progetto Abstract del progetto
Nome Daniela Tardito Contatti Tel. E mail Tel: +390250318382 E-mail: daniela.tardito@unimi.it Istituto/Dipartimento Center of Neuropharmacology, Department of Pharmacological Sciences, CEND, University of Milan Proposta di ricerca Area di interesse identificata 1A. Toward exploiting the screening potential of miRNome for the identification of genes and pathways involved in neurodegenerative disorders Finanziamenti ricevuti Titolo progetto Ente finanziatore Durata progetto Abstract del progetto The regulation of neuroplasticity in the response to therapeutic drugs for mood disorders. The role of micro RNAs Cariplo Foundation March 2010-february 2013 Aim of this project is to investigate, by means of an integrated approach that merges preclinical and clinical studies with up-todate bioinformatic, pharmacological, genomic and genetic techniques, the role of the posttranscriptional regulators miRNAs in Mood Disorders aetiology and antidepressant response, with regard to neuroplasticity. Overall, the main objectives of the present project will be: 1. to clarify the role of miRNAs in the molecular effects of different antidepressants on the posttranscriptional modulation of genes coding for modulators of neuroplasticity with an integrate approach based on preclinical and clinical studies. 2. to discover new molecular targets for the development of innovative therapeutic strategies for the treatment of drug resistant depression 3. to identify molecular markers associated to the antidepressant response in human peripheral tissues for the optimization of drug treatment in mood disorders. The integration of data obtained in clinical and preclinical studies will permit the validation of blood leucocytes as cellular models for the study of mental disorders 4. to identify new susceptibility genes and pharmacogenetic markers for optimization of treatment in mood disorders.
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Page 35 and 36: Nome Maurizio Taglialatela, MD PhD
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Page 39 and 40: Nome MARIO MARCHI Contatti marchi@p
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Funding agency European Commission
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Nome Elisabetta VEGETO Contatti Tel
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Nome Dr. Barbara Viviani Prof. Mari
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Nome ANGELINI - ACRAF SpA Contatti
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• Ruolo neuroprotettivo della Tim
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1. MECHANISMS OF NEURODEGENERATION
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degeneration in PD. Although the ox
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mitochondrial ANT. Titolo progetto
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Titolo progetto Ente finanziatore M
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on potential mechanisms of abnormal
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Country: Italy Contact person: Paol
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Nome Roberto Rimondini-Giorgini Con
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Nome Rosa Maria Corbo Contatti Rosa
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Nome Prof. LUCIA MIGLIORE Contatti
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Nome LAURA COLOMBAIONI Contatti lau
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Nome Roberto Maggi Contatti Tel. E
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devoted to study the role of two ho
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years old nuns and the failure of p
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Nome Manuela MARCOLI Contatti Dipar
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Finanziamenti ricevuti - submitted
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or purinergic receptors (e.g. P2X7)
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increased expression of neuronal RA
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Titolo progetto appearance of neuro
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Nome Cecilia Bucci Contatti Tel. +3
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Nome Prof. Paolo Macchi, PhD Contat
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healthy patients with PD and to hig
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Nome Adalberto MERIGHI Contatti Pho
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Abstract del progetto Several neuro
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Nome Monica DiLuca Contatti Univers
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Nome Prof. Renata Bartesaghi Contat
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Nome Sonia Levi Contatti +39 022643
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2. PHARMACOLOGY A- Drug Design
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Nome Carlo Melchiorre Contatti e-ma
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Nome Prof. Federico Da Settimo, Pro
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Nome Alberto Cassetta Contatti Albe
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2. PHARMACOLOGY B-Drug screening
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Nome Iliana Ferrero Fortunati Conta
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341 810-5 Palmieri L, Alberio S, Pi
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2. PHARMACOLOGY C- Drug Delivery
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Colloidal drug carriers include mic
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o Novel peptides for the engineerin
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y thoughtfully varying synthesis co
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cocktails, aerosols) will be employ
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Nome Contatti Lamberto Maffei maffe
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Nome Prof. Aldo Andreani Contatti P
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[4] Andreani A., Burnelli S., Grana
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Bruno Olga Role: Co-investigator Du
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transgenic mouse lines expressing A
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Tg-AD mice” Ente finanziatore Pha
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maximizes the potential for neurolo
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NSC delivery. The aim is to use pro
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Nome Maria P. Abbracchio Contatti T
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Nome Mariagrazia Grilli/Pier Luigi
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Nome Fabrizio Chiti Contatti Tel. E
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Ente finanziatore Regione Toscana D
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Country: Italy Contact person: Pio
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progetto Ente finanziatore Durata p
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Objectives. The primary objective i
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Nome PATRIZIA BISIACCHI Contatti 04
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Durata progetto Abstract del proget
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Finanziamenti ricevuti Titolo proge
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Nome Federico Schena Contatti Feder
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Nome Prof. Enrico Granieri Contatti
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2. PHARMACOLOGY F. Drug Pharmacogen
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guidelines for the I.R.C.C.S. and w
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2. PHARMACOLOGY G. Clinical studies
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conventional and non conventional a
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Country: Italy Contact person: Gabb
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Country: Italy Contact person: Mica
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Nome Valerio Carelli, MD, PhD Conta
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process. Rev Neurosci. 2008;19(4-5)
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Nome Prof. Roberto Lucchini Contatt
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REFERENCES Baccarelli A, Bollati V.
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Nome Giuseppe Mele (Professore Aggr
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Nome Prof. Calogero Caruso MED04 Co
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Roberto Monastero, MD, PhD Lab of E
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Ente finanziatore Durata progetto A
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Nome Prof. Carlo Caltagirone Contat
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Nome Manservigi Roberto Contatti Te
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Nome Luisa Benussi, Giuliano Binett
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Nome Maria Del Zompo Contatti Phone
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Nome Patrizia Mecocci Contatti meco
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Nome Prof. Salvatore Monaco Contatt
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integrated in the pipeline (see www
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e costosa. Area di interesse identi
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Contatti Flaviomariano.nobili@hsanm
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FDG-PET. CSF assays are performed i
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Nome Daniela Perani Contatti Tel. E
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Nome Maurizio Popoli Contatti Tel.
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Sorting, reduced Stroop Color-Word
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the effect of caregiver support on
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Nome Lucilla Parnetti Contatti Clin
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hexosaminidase, beta-galactosidase,
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Nome Roberta Ghidoni, Giuliano Bine
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Referente: Prof. Carlo Ferrarese Ph
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Nome Piero Parchi M.D., Ph.D. Conta
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SICILIANO Analisi biochimica di par
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Nome Laura Calzà Contatti laura.ca
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We will collect systematically plas
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frontotemporal dementia and prion d
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Allegra MR Imager with a standard q
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Nome Maurizio Balestrino Contatti 0
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I principali progetti di ricerca at
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particularly in tasks of episodic m
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3. HUMAN/CLINICAL RESEARCH G. Ambie
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Country: ITALY Contact person: Ales
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esults are: 1) the number of patien
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Nome Vincenzo Mario Bruno GIORGINO
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Mapping of Italian research excellence in Neurodegenerative - Apre

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