Mapping of Italian research excellence in Neurodegenerative - Apre
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Mapping of Italian research excellence in Neurodegenerative - Apre

Mapping of Italian research excellence in Neurodegenerative - Apre

Mapping of Italian research excellence in Neurodegenerative - Apre

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Nome Tanganelli Sergio<br />

Contatti<br />

tgs@unife.it<br />

Istituto/Dipartimento Dept. <strong>of</strong> Cl<strong>in</strong>ical and Experimental Medic<strong>in</strong>e<br />

Pharmacology Section, University <strong>of</strong> Ferrara, Italy<br />

Proposta di ricerca<br />

Area di <strong>in</strong>teresse identificata<br />

F<strong>in</strong>anziamenti ricevuti<br />

Titolo progetto<br />

Ente f<strong>in</strong>anziatore<br />

Durata progetto<br />

Abstract del progetto<br />

Mechanisms <strong>of</strong> Neurodegeneration : A. Macromolecular <strong>in</strong>teractions and<br />

Neurodegeneration<br />

Neurotens<strong>in</strong> and neurotens<strong>in</strong> antagonist <strong>in</strong> an animal model <strong>of</strong> Park<strong>in</strong>son’s<br />

disease: therapeutic perspectives and role <strong>of</strong> NMDA/neurotens<strong>in</strong> <strong>in</strong>teraction.<br />

San<strong>of</strong>i-Aventis<br />

2007-2010<br />

The tridecapeptide neurotens<strong>in</strong> (NT) significantly enhances glutamatergic<br />

signal<strong>in</strong>g <strong>in</strong> different bra<strong>in</strong> areas and amplifies the NMDA-receptor signal<strong>in</strong>g,<br />

probably by activat<strong>in</strong>g the high-aff<strong>in</strong>ity neurotens<strong>in</strong> receptor (NTS1), as shown by<br />

the NTS1receptor antagonist SR48692-<strong>in</strong>duced counteraction <strong>of</strong> this effect.<br />

These f<strong>in</strong>d<strong>in</strong>gs suggest a re<strong>in</strong>forc<strong>in</strong>g action <strong>of</strong> NT on several functions exerted by<br />

glutamate <strong>in</strong> the central nervous system, <strong>in</strong> particular on the glutamatemediated<br />

excitotoxicity. NT could be implicated <strong>in</strong> the pathogenesis <strong>of</strong> chronic<br />

and acute neurodegenerative disorders, such as Park<strong>in</strong>son’s disease. To further<br />

<strong>in</strong>vestigate this hypothesis, the aims <strong>of</strong> the project, which will comb<strong>in</strong>e<br />

biochemical, functional, morphological and behavioral experiments, will be<br />

evaluate: 1) the putative neuroprotective effects <strong>of</strong> a pretreatment with SR48692<br />

(systemically adm<strong>in</strong>istered) <strong>in</strong> an animal model <strong>of</strong> Park<strong>in</strong>son’s disease [unilateral<br />

6-hydroxydopam<strong>in</strong>e (6-OHDA) lesion]; 2) the functional and physio-pathological<br />

relevance <strong>of</strong> NMDA/NT receptor <strong>in</strong>teractions <strong>in</strong> the striatum <strong>of</strong> naïve and 6-<br />

OHDA -lesioned rats.

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