Mapping of Italian research excellence in Neurodegenerative - Apre

cellular defence mechanisms by chemical inducers, such as
isothiocyanates from natural sources, among which sulforaphane
(SF). Molecular and cellular mechanisms behind SF neuroprotection
will be initially studied in vitro, through an experimental approach
which let us to evaluate neuroprotective and/or neurorescue effects
by SF. Neuronal damage parameters at the cellular level will
comprise the induction of neuronal death in terms of
apoptosis/necrosis and the activation of cellular death/survival
biochemical pathways. The scientifically important expectation of
this project, by providing data on the cellular and molecular
mechanisms commanding cell death in neurodegeneration and
behind neuroprotection by SF, is to provide a clear rationale for
delineating innovative pharmacological strategies to counteract and
rescue neurodegeneration.