Mapping of Italian research excellence in Neurodegenerative - Apre

ST14A, select a mouse strain able to develop the neurodegenerative disease in absence of Titf-1, and
characterize the genotype/phenotype association of TiTF-1 in a cohort of patient with neurodegenerative
diseases.
Provenzano C, Veneziano L, Appleton R, Frontali M, Civitareale D. Functional characterization of a novel
mutation in TITF-1 in a patient with benign hereditary chorea. J Neurol Sci. 2008 264(1-2):56-62.
Provenzano C, Pascucci B, Lupari E and Civitareale D. Large scale analysis of transcription factor TTF-
1/NKX2.1 target genes in GnRH secreting cell line GT1-7. Molecular and Cellular Endocrinology. In press.
Area di interesse identificata
Basic research : developing competitive in vitro and in vivo models to
study Alzheimer’s Disease; new treatment strategies based on
Neurotrophins. Biobanking
(DNA), sharing database, exchanging and pooling data
Finanziamenti ricevuti Role of microRNAs in Alzheimer’s Disease onset and progression (C. Barbato, C
Cogoni, F. Ruberti,).
Ongoing Research Support -3886
SD/sd 2008.2404 Programma Neuroscienze “Compagnia di San Paolo” 9/01/09-9/01/11:
‘MIND: MicroRNA In Neurodegenerative Diseases’ (to C. Barbato)
-REGIONE LAZIO grant 2009-2011: ‘Studio delle basi molecolari della neurodegenerazione
nella malattia di Alzheimer’- (to C.Cogoni).
Completed Research Support -
DG.RSTL.059.012 –CNR grant-01/2008-12/2009. “Study of APP regulation by microRNAs
and implication in Alzheimer’s Disease” (to F. Ruberti)
Finanziamenti ricevuti Mechanisms underlying the effect of N-terminal 26-230 tau fragment on synaptic
dysfunction and neurodegeration (N. Canu).
Ongoing Research Support -
Dipartimento di Neuroscience, University of Tor Vergata
Completed Research Support -
MIUR-PRIN 2006-2008: “Molecular and behavioural analysis of tau neurotoxic effect in
cellular and animal models”
-Ministero della Sanità- Ex Articolo 56 Neurodegenerativo 533F/B/1 2005-2009
“Identificazione di marcatori biologici precoci per la demenza di Alzheimer: genomica e
proteomica nella neurodegenerazione”
Finanziamenti ricevuti Nerve Growth Factor deprivation pathways leading to Alzheimer’s Disease
phenotype (C. Matrone, P. Calissano).
Ongoing Research Support -
MIUR-FIRB Italy / 2009-2011
“Italian Human Proteome Net” -
MIUR-PRIN 2009/2011
“Ruolo di Zn e Cu nella cascata amiloidogenica provocata da deprivazione di NGF”
Finanziamenti ricevuti Role of NH2-26-44 tau peptide in Alzheimer Disease (G. Amadoro P. Calissano)
Ongoing Research Support -
MIUR-FIRB 24-09-08 al 24-09-11: “Italian Human Proteome Net” -
MIUR 18-07-2007 to 18-07-2010: “Neurotrophic and neuroprotective drugs suitable for
therapeutic applications in neuroscience: AD,HD,SLA”
Finanziamenti ricevuti Mitochondrial damage and genetic risk/susceptibility factors in Alzheimer’s