Ticagrelor versus clopidogrel in patients with acute coronary ...
Ticagrelor versus clopidogrel in patients with acute coronary ...
Ticagrelor versus clopidogrel in patients with acute coronary ...
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Transfusions from time of CABG<br />
CABG<br />
Characteristic<br />
Transfusions <strong>with</strong><strong>in</strong> 7 days post-CABG<br />
Any transfusion<br />
<strong>Ticagrelor</strong><br />
(n=632)<br />
Clopidogrel<br />
(n=629)<br />
55.2 55.8<br />
Hazard/Odds Ratio (95% CI)<br />
0.98 (0.85, 1.14)<br />
p-value<br />
0.83<br />
PRBC or whole blood*<br />
52.7 51.2<br />
1.03 (0.88, 1.20)<br />
0.69<br />
Platelets<br />
15.3 17.3<br />
0.88 (0.67, 1.16)<br />
0.37<br />
Fresh frozen plasma 25.2 24.0<br />
1.05 (0.84, 1.31)<br />
0.67<br />
>4 units blood<br />
17.9 16.2<br />
1.12 (0.83, 1.53)<br />
Transfusions post CABG-related bleed<strong>in</strong>g † 1.25 (0.70, 2.23)<br />
>5 units whole blood/<br />
PRBC (2 days)<br />
4.9 4.0<br />
Chest tube output >2L<br />
1.24 (0.61, 2.52)<br />
3.3 2.7<br />
(24 hours) †<br />
0.45<br />
0.49<br />
0.62<br />
0.2<br />
0.5 1.0 2.0<br />
Event rate is number of events divided by n<br />
<strong>Ticagrelor</strong> better Clopidogrel better<br />
*Median (range) units transfused <strong>with</strong><strong>in</strong> 7 days post-CABG: tic 3.0 (2.0–4.0) vs. clop 3.0 (2.0–4.0); p=0.86<br />
† Odds ratio and p-value from Fisher’s exact test
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