Ticagrelor versus clopidogrel in patients with acute coronary ...

More documents

Recommendations

Info

Transfusions from time of CABG CABG Characteristic Transfusions within 7 days post-CABG Any transfusion Ticagrelor (n=632) Clopidogrel (n=629) 55.2 55.8 Hazard/Odds Ratio (95% CI) 0.98 (0.85, 1.14) p-value 0.83 PRBC or whole blood* 52.7 51.2 1.03 (0.88, 1.20) 0.69 Platelets 15.3 17.3 0.88 (0.67, 1.16) 0.37 Fresh frozen plasma 25.2 24.0 1.05 (0.84, 1.31) 0.67 >4 units blood 17.9 16.2 1.12 (0.83, 1.53) Transfusions post CABG-related bleeding † 1.25 (0.70, 2.23) >5 units whole blood/ PRBC (2 days) 4.9 4.0 Chest tube output >2L 1.24 (0.61, 2.52) 3.3 2.7 (24 hours) † 0.45 0.49 0.62 0.2 0.5 1.0 2.0 Event rate is number of events divided by n Ticagrelor better Clopidogrel better *Median (range) units transfused within 7 days post-CABG: tic 3.0 (2.0–4.0) vs. clop 3.0 (2.0–4.0); p=0.86 † Odds ratio and p-value from Fisher’s exact test
Limitations CABG • Retrospective analysis of a non-randomized subgroup of patients requiring CABG – selection bias, survivor bias or other confounders • The formal adjudication of causes of deaths in the main trial separated death from vascular and non-vascular cause, but a further subcategorization was not performed – a retrospective central review of the causes of post-CABG death is currently ongoing
Page 1 and 2: CABG Ticagrelor versus clopidogrel
Page 3 and 4: Ticagrelor (AZD 6140): an oral reve
Page 5 and 6: Objectives CABG The objective of th
Page 7 and 8: Patient disposition CABG 18,624 pat
Page 9 and 10: Evaluations and invasive procedures
Page 11 and 12: Study medication pre- and post-CABG
Page 13 and 14: Time from CABG to primary endpoint:
Page 15 and 16: Time from CABG to CV death (CABG po
Page 17: Bleeding from time of CABG CABG Cha

Ticagrelor versus clopidogrel in patients with acute coronary ...

Create successful ePaper yourself

Delete template?

Save as template?