“A structure based flexible search method for motifs in RNA” Isana ...
“A structure based flexible search method for motifs in RNA” Isana ...
“A structure based flexible search method for motifs in RNA” Isana ...
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Tak<strong>in</strong>g <strong>in</strong>to account sequence<br />
considerations<br />
Variety of sequence considerations:<br />
� Sequence alignment criterion on the<br />
s<strong>in</strong>gle strand regions like bulges and<br />
loops (tRNA and riboswitches)<br />
� Sequence alignment scor<strong>in</strong>g on the<br />
compared stems (miRNA)<br />
� Sequence comparisons are per<strong>for</strong>med<br />
on the small number of filtered<br />
candidates � the effect of its runtime<br />
on the overall <strong>search</strong> is negligible.<br />
Target database<br />
Filter<strong>in</strong>g by <strong>structure</strong> constra<strong>in</strong>ts<br />
Relatively small<br />
number of <strong>structure</strong>s<br />
Apply<strong>in</strong>g sequence constra<strong>in</strong>ts<br />
F<strong>in</strong>al set of candidates
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