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Mental Illness and Serious Harm to Others - University of Liverpool

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NHS National Programme on Forensic <strong>Mental</strong> Health Research <strong>and</strong> Development<br />

rate on cessation (e.g. Kane, 1996). A substantial minority <strong>of</strong> patients benefit little from<br />

conventional antipsychotic drugs (Schulz <strong>and</strong> Buckley, 1995), but many <strong>of</strong> these may be<br />

helped by the so-called atypical antipsychotics - clozapine, <strong>and</strong> the medications mostly<br />

new <strong>to</strong> the 1990s. Do they <strong>of</strong>fer any advantage in limiting violence in the context <strong>of</strong><br />

these illnesses?<br />

A number <strong>of</strong> reviews have highlighted evidence which suggests that effective medication<br />

may confer advantage with respect <strong>to</strong> violence in the acute situation (Royal College <strong>of</strong><br />

Psychiatrists, 1998) <strong>and</strong> more generally (Taylor <strong>and</strong> Buckley, 2000; Tiihonen <strong>and</strong> Swartz,<br />

2000; Volavka <strong>and</strong> Citrome, 2000). Naturalistic studies in the English high security<br />

hospitals <strong>of</strong> the impact <strong>of</strong> clozapine on improvement <strong>of</strong> disorder <strong>and</strong> reduction in violence<br />

(Dalal et al, 1999) <strong>and</strong> on shortening stay for the longer-term group with schizophrenia<br />

(Swin<strong>to</strong>n <strong>and</strong> Haddock, 2000) are encouraging, although for a variety <strong>of</strong> reasons, many<br />

patients who might benefit appear <strong>to</strong> be unsuitable for this drug (Swin<strong>to</strong>n <strong>and</strong><br />

Ahmed,1999). There is some suggestion that it may be possible <strong>to</strong> contain 'disruptive’,<br />

<strong>and</strong> perhaps violent behaviour, among patients with psychosis, even when the symp<strong>to</strong>ms<br />

<strong>of</strong> the illness are not improved (e.g. Kane <strong>and</strong> Marder, 1993; Marder et al, 1997).<br />

However, these studies focus exclusively on the presence or absence <strong>of</strong> symp<strong>to</strong>ms. The<br />

drugs may still be exerting an effect through the illness, rather than having some<br />

independent or perhaps specifically anti-aggressive effect. In this context, it is likely <strong>to</strong><br />

be important also <strong>to</strong> measure the impact <strong>of</strong> symp<strong>to</strong>ms (Taylor et al, 1994), for example<br />

the extent <strong>to</strong> which a given symp<strong>to</strong>m makes the patient frightened or depressed, <strong>and</strong> the<br />

extent <strong>to</strong> which the medication can at least relieve the effect.<br />

There are at least four important problems with the treatment data <strong>to</strong> date:<br />

❑ Violence has a low base rate, even within groups <strong>of</strong> people who have been violent or<br />

threaten it, so attributes like 'hostility’ <strong>and</strong> 'aggression’ are taken as surrogates for<br />

violence, without evidence that it is valid <strong>to</strong> do so.<br />

❑ The data are overly dependent on uncontrolled <strong>and</strong> non-r<strong>and</strong>omised studies. It is not<br />

at all clear that measures that are effective for inpatients translate <strong>to</strong> life in the wider<br />

community.<br />

❑ The kind <strong>of</strong> drug combinations preferred by many in practice for people who have<br />

been seriously violent in the context <strong>of</strong> their mental illness - commonly a conventional<br />

depot neuroleptic combined with an atypical antipsychotic drug taken by mouth -<br />

have not been adequately tested, particularly for the long term.<br />

❑ Medication may be a necessary treatment for most people with psychosis in this<br />

context, but it is rarely, if ever, sufficient. Psychological approaches <strong>to</strong> reduce specific<br />

symp<strong>to</strong>ms or their impact are promising (e.g. Garety et al, 1994; Tarrier et al, 1998),<br />

but the findings as yet not directly tested in this field.<br />

Growing acknowledgement <strong>of</strong> the fact that violence is an interactional problem, <strong>and</strong> that<br />

even where one party may be a clear instiga<strong>to</strong>r, reactions can diffuse or escalate the<br />

situation, leads <strong>to</strong> the possibility that specific interventions with family, other carers or<br />

staff may be as helpful <strong>to</strong> the patient as more directly patient-oriented work. So far, the<br />

emphasis for staff is on various aspects <strong>of</strong> training (e.g. Phillips <strong>and</strong> Rudestam, 1995;<br />

Taylor <strong>and</strong> Sch<strong>and</strong>a, 2000), but the concept <strong>of</strong> high expressed emotion (EE) may prove <strong>to</strong><br />

be as applicable <strong>to</strong> staff working in long-term relationships with patients as <strong>to</strong> the close<br />

11

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