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Winter 1992, Volume 17, Number 2 - Association of Schools and ...

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On this, <strong>and</strong> on all other modules,<br />

the user may click on the ERASE<br />

button at the top <strong>of</strong> the screen at any<br />

time, <strong>and</strong> the default screen will reappear.<br />

There is also a push button<br />

labeled "Menu" which allows the<br />

user to return to the main menu<br />

(Figure 1) to make a different choice.<br />

The Menu push button is found in<br />

all modules.<br />

PI<br />

[Menu I<br />

Filff<br />

Click on one <strong>of</strong><br />

buttons to<br />

change state<br />

The Voltnne noted Snrliui<br />

Outside ©@<br />

IERRSE1<br />

(2) DIAGRAMS ILLUSTRATING<br />

PHYSIOLOGICAL CONCEPTS<br />

The program contains four modules<br />

in this category: The Voltage<br />

Gated Potassium Channel, The Voltage<br />

Gated Sodium Channel, Horner's<br />

Syndrome, <strong>and</strong> Sympathetic Neurohumoral<br />

Transmission. Figure 4<br />

shows two superimposed screens<br />

from the module, The Voltage Gated<br />

Sodium Channel.<br />

The top (rear) screen represents the<br />

resting state <strong>of</strong> the sodium channel<br />

<strong>and</strong> is the default presentation. The<br />

lower (front) screen represents the<br />

open state, <strong>and</strong> appears when the<br />

"open" push button is clicked.<br />

Whenever a state push button is<br />

clicked, (1) the inactivation <strong>and</strong><br />

activation gates are redrawn, (2) the<br />

text adjacent to the gates is replaced<br />

with terms that specify their current<br />

status, <strong>and</strong> (3) the text at the bottom<br />

<strong>of</strong> the channel is replaced with a<br />

phrase that specifies the corresponding<br />

phase <strong>of</strong> the action<br />

potential.<br />

(3) RECORDS FROM EXPERIMENTS<br />

Review Drawings apl contains two<br />

modules in this category: Effect <strong>of</strong><br />

Ions <strong>and</strong> Drugs on Voltage Clamp<br />

Records, <strong>and</strong> Threshold <strong>and</strong> Subthreshold<br />

Stimuli. Figure 5 shows two<br />

superimposed screens from Effect <strong>of</strong><br />

Ions <strong>and</strong> Drugs on Voltage Clamp<br />

Records.<br />

The upper (rear) screen is displayed<br />

when the module is first started. It<br />

shows a typical voltage clamp record,<br />

illustrating normal tracings <strong>of</strong> membrane<br />

voltage <strong>and</strong> current. The three<br />

distinct current phases carry push<br />

buttons which, when clicked, identify<br />

the sources <strong>of</strong> those currents.<br />

The right side <strong>of</strong> the lower (front)<br />

screen shows the voltage clamp<br />

record after the Local Anesthetic<br />

button in the lower horizontal row<br />

had been clicked.<br />

This module helps students underst<strong>and</strong><br />

how ion substitution experiments<br />

can illuminate the early inward<br />

IINBCTIUHTEDI<br />

IREFRBCTORV"<br />

111 Hie<br />

[Menu I<br />

I OPEN 1<br />

IINRCTIURTEDI<br />

IREFRRCT0RV1<br />

The voltaae-aated Sodium Channel<br />

Inside<br />

INACTIVATION<br />

ATE CLOSED<br />

ACTIVATION<br />

GATES OPEN<br />

Channel closed, do wnstr<strong>of</strong>ce AP<br />

[EBBSE1<br />

Figure 4. Two superimposed screens from the module, The Voltage-Gated Sodium<br />

Channel, representative <strong>of</strong> Drawings Illustrating Physiological Concepts.<br />

File<br />

liJJJIJl lltect ntlons onri nruir<br />

out<br />

M<br />

in<br />

-70<br />

INa(out<br />

Current?!<br />

MMsmamm OBID<br />

File<br />

^^,«7mCTTMI ll,l ;l.l,l ll,l.ll,L-l,n»J,lll.l,I.IJI.I.,l.rCTTfT» m^?<br />

M<br />

'Capacity current<br />

-70 |-<br />

time (msec)<br />

Normal Control Record<br />

K current<br />

la current<br />

out<br />

In<br />

-70 F-T time (msec)<br />

Record with Local Anesthetic<br />

INaloutl ' Nallnll IK(ln) » KlouOl I Local Anesthetic 1 I TTH I [ TEH 1<br />

on ami hut tort to proceed<br />

Figure 5. Two superimposed screens from the module, Effect <strong>of</strong> Ions <strong>and</strong> Drugs on<br />

Voltage Clamp Records, illustrating Records from Experiments.<br />

<strong>Volume</strong> <strong>17</strong>, <strong>Number</strong> 2 / <strong>Winter</strong> 1991 51

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