Winter 1992, Volume 17, Number 2 - Association of Schools and ...
Winter 1992, Volume 17, Number 2 - Association of Schools and ...
Winter 1992, Volume 17, Number 2 - Association of Schools and ...
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On this, <strong>and</strong> on all other modules,<br />
the user may click on the ERASE<br />
button at the top <strong>of</strong> the screen at any<br />
time, <strong>and</strong> the default screen will reappear.<br />
There is also a push button<br />
labeled "Menu" which allows the<br />
user to return to the main menu<br />
(Figure 1) to make a different choice.<br />
The Menu push button is found in<br />
all modules.<br />
PI<br />
[Menu I<br />
Filff<br />
Click on one <strong>of</strong><br />
buttons to<br />
change state<br />
The Voltnne noted Snrliui<br />
Outside ©@<br />
IERRSE1<br />
(2) DIAGRAMS ILLUSTRATING<br />
PHYSIOLOGICAL CONCEPTS<br />
The program contains four modules<br />
in this category: The Voltage<br />
Gated Potassium Channel, The Voltage<br />
Gated Sodium Channel, Horner's<br />
Syndrome, <strong>and</strong> Sympathetic Neurohumoral<br />
Transmission. Figure 4<br />
shows two superimposed screens<br />
from the module, The Voltage Gated<br />
Sodium Channel.<br />
The top (rear) screen represents the<br />
resting state <strong>of</strong> the sodium channel<br />
<strong>and</strong> is the default presentation. The<br />
lower (front) screen represents the<br />
open state, <strong>and</strong> appears when the<br />
"open" push button is clicked.<br />
Whenever a state push button is<br />
clicked, (1) the inactivation <strong>and</strong><br />
activation gates are redrawn, (2) the<br />
text adjacent to the gates is replaced<br />
with terms that specify their current<br />
status, <strong>and</strong> (3) the text at the bottom<br />
<strong>of</strong> the channel is replaced with a<br />
phrase that specifies the corresponding<br />
phase <strong>of</strong> the action<br />
potential.<br />
(3) RECORDS FROM EXPERIMENTS<br />
Review Drawings apl contains two<br />
modules in this category: Effect <strong>of</strong><br />
Ions <strong>and</strong> Drugs on Voltage Clamp<br />
Records, <strong>and</strong> Threshold <strong>and</strong> Subthreshold<br />
Stimuli. Figure 5 shows two<br />
superimposed screens from Effect <strong>of</strong><br />
Ions <strong>and</strong> Drugs on Voltage Clamp<br />
Records.<br />
The upper (rear) screen is displayed<br />
when the module is first started. It<br />
shows a typical voltage clamp record,<br />
illustrating normal tracings <strong>of</strong> membrane<br />
voltage <strong>and</strong> current. The three<br />
distinct current phases carry push<br />
buttons which, when clicked, identify<br />
the sources <strong>of</strong> those currents.<br />
The right side <strong>of</strong> the lower (front)<br />
screen shows the voltage clamp<br />
record after the Local Anesthetic<br />
button in the lower horizontal row<br />
had been clicked.<br />
This module helps students underst<strong>and</strong><br />
how ion substitution experiments<br />
can illuminate the early inward<br />
IINBCTIUHTEDI<br />
IREFRBCTORV"<br />
111 Hie<br />
[Menu I<br />
I OPEN 1<br />
IINRCTIURTEDI<br />
IREFRRCT0RV1<br />
The voltaae-aated Sodium Channel<br />
Inside<br />
INACTIVATION<br />
ATE CLOSED<br />
ACTIVATION<br />
GATES OPEN<br />
Channel closed, do wnstr<strong>of</strong>ce AP<br />
[EBBSE1<br />
Figure 4. Two superimposed screens from the module, The Voltage-Gated Sodium<br />
Channel, representative <strong>of</strong> Drawings Illustrating Physiological Concepts.<br />
File<br />
liJJJIJl lltect ntlons onri nruir<br />
out<br />
M<br />
in<br />
-70<br />
INa(out<br />
Current?!<br />
MMsmamm OBID<br />
File<br />
^^,«7mCTTMI ll,l ;l.l,l ll,l.ll,L-l,n»J,lll.l,I.IJI.I.,l.rCTTfT» m^?<br />
M<br />
'Capacity current<br />
-70 |-<br />
time (msec)<br />
Normal Control Record<br />
K current<br />
la current<br />
out<br />
In<br />
-70 F-T time (msec)<br />
Record with Local Anesthetic<br />
INaloutl ' Nallnll IK(ln) » KlouOl I Local Anesthetic 1 I TTH I [ TEH 1<br />
on ami hut tort to proceed<br />
Figure 5. Two superimposed screens from the module, Effect <strong>of</strong> Ions <strong>and</strong> Drugs on<br />
Voltage Clamp Records, illustrating Records from Experiments.<br />
<strong>Volume</strong> <strong>17</strong>, <strong>Number</strong> 2 / <strong>Winter</strong> 1991 51