Dr. Ross Mikkelsen - Pathology - Virginia Commonwealth University

B. Selected Peer­Reviewed Publications (in chronological order)
1. Mikkelsen, R. B., Stedman, T., Schmidt­Ullrich, R., and Lin, P. S. Effects of tamoxifen and protein kinase C
inhibitors on hyperthermic cell killing. Int J Radiat Oncol Biol Phys, 20: 1039­1045, 1991.
2. Mikkelsen, R. B. and Gentry, C. A radiation­induced inhibitor of chromosome condensation and nuclear
envelope breakdown in HeLa cells. Radiat Res, 132: 158­161, 1992.
3. Todd, D. G. and Mikkelsen, R. B. Ionizing radiation induces a transient increase in cytosolic free [Ca 2+ ] in
human epithelial tumor cells. Cancer Res, 54: 5224­5230, 1994.
4. Grant, S., Freemerman, A. J., Gregory, P. C., Martin, H. A., Turner, A. J., Mikkelsen, R., Chelliah, J.,
Yanovich, S., and Jarvis, W. D. Induction of apoptotic DNA fragmentation and c­jun downregulation in human
myeloid leukemia cells by the permeant Ca 2+ chelator BAPTA/AM. Oncol Res, 7: 381­392, 1995.
5. Gatmaitan, Z., Varticovski, L., Ling, L., Mikkelsen, R., Steffan, A. M., and Arias, I. M. Studies on fenestral
contraction in rat liver endothelial cells in culture. Am J Pathol, 148: 2027­2041, 1996.
6. Rao, A. S., Freemerman, A. J., Jarvis, W. D., Chelliah, J., Bear, H. D., Mikkelsen, R., and Grant, S. Effect
of AS101 on bryostatin 1­mediated differentiation induction, cell cycle arrest, and modulation of drug­induced
apoptosis in human myeloid leukemia cells. Leukemia, 10: 1150­1158, 1996.
7. Schmidt­Ullrich, R. K., Mikkelsen, R. B., Dent, P., Todd, D. G., Valerie, K., Kavanagh, B. D., Contessa, J.
N., Rorrer, W. K., and Chen, P. B. Radiation­induced proliferation of the human A431 squamous carcinoma
cells is dependent on EGFR tyrosine phosphorylation. Oncogene, 15: 1191­1197, 1997.
8. Carter, S., Auer, K. L., Reardon, D. B., Birrer, M., Fisher, P. B., Valerie, K., Schmidt­Ullrich, R., Mikkelsen,
R., and Dent, P. Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low
dose ionizing radiation in A431 human squamous carcinoma cells. Oncogene, 16: 2787­2796, 1998.
9. Kavanagh, B. D., Dent, P., Schmidt­Ullrich, R. K., Chen, P., and Mikkelsen, R. B. Calcium­dependent
stimulation of mitogen­activated protein kinase activity in A431 cells by low doses of ionizing radiation. Radiat
Res, 149: 579­587, 1998.
10. Contessa, J. N., Reardon, D. B., Todd, D., Dent, P., Mikkelsen, R. B., Valerie, K., Bowers, G. D., and
Schmidt­Ullrich, R. K. The inducible expression of dominant­negative epidermal growth factor receptor­CD533
results in radiosensitization of human mammary carcinoma cells. Clin Cancer Res, 5: 405­411, 1999.
11. Reardon, D. B., Contessa, J. N., Mikkelsen, R. B., Valerie, K., Amir, C., Dent, P., and Schmidt­Ullrich, R. K.
Dominant negative EGFR­CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation
toxicity of human mammary carcinoma cells. Oncogene, 18: 4756­4766, 1999.
12. Todd, D. G., Mikkelsen, R. B., Rorrer, W. K., Valerie, K., and Schmidt­Ullrich, R. K. Ionizing radiation
stimulates existing signal transduction pathways involving the activation of epidermal growth factor receptor
and ERBB­3, and changes of intracellular calcium in A431 human squamous carcinoma cells. J Recept Signal
Transduct Res, 19: 885­908, 1999.
13. Tombes, R. M., Mikkelsen, R. B., Jarvis, W. D., and Grant, S. Downregulation of delta CaM kinase II in
human tumor cells. Biochim Biophys Acta, 1452: 1­11, 1999.
14. Schmidt­Ullrich, R. K., Dent, P., Grant, S., Mikkelsen, R. B., and Valerie, K. Signal transduction and cellular
radiation responses. Radiat Res, 153: 245­257, 2000.
15. Bowers, G., Reardon, D., Hewitt, T., Dent, P., Mikkelsen, R. B., Valerie, K., Lammering, G., Amir, C., and
Schmidt­Ullrich, R. K. The relative role of ErbB1­4 receptor tyrosine kinases in radiation signal transduction
responses of human carcinoma cells. Oncogene, 20: 1388­1397, 2001.