Dr. Ross Mikkelsen - Pathology - Virginia Commonwealth University

16. Lammering, G., Hewit, T. H., Hawkins, W. T., Contessa, J. N., Reardon, D. B., Lin, P. S., Valerie, K., Dent,
P., Mikkelsen, R. B., and Schmidt­Ullrich, R. K. Epidermal growth factor receptor as a genetic therapy target for
carcinoma cell radiosensitization. J Natl Cancer Inst, 93: 921­929, 2001.
17. Lammering, G., Valerie, K., Lin, P. S., Mikkelsen, R. B., Contessa, J. N., Feden, J. P., Farnsworth, J., Dent,
P., and Schmidt­Ullrich, R. K. Radiosensitization of malignant glioma cells through overexpression of
dominant­negative epidermal growth factor receptor. Clin Cancer Res, 7: 682­690, 2001.
18. Leach, J. K., Van Tuyle, G., Lin, P. S., Schmidt­Ullrich, R., and Mikkelsen, R. B. Ionizing radiation­induced,
mitochondria­dependent generation of reactive oxygen/nitrogen. Cancer Res, 61: 3894­3901, 2001.
19. Leach, J. K., Black, S. J., Schmidt­Ullrich, R. K., and Mikkelsen, R.B. Activation of constitutive nitric oxide
synthase activity as an early signaling event induced by ionizing radiation. J Biol Chem, 277: 15400­15406,
2002.
20. Contessa, J. N., Hampton, J., Lammering, G., Mikkelsen, R. B., Dent, P., Valerie, K., and Schmidt­Ullrich,
R. K. Ionizing radiation activates Erb­B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells.
Oncogene. 21: 4032­4041, 2002.
21. Ho, K. C., Leach, J. K., Eley, K., Mikkelsen, R.B., and Lin, P. S. A simple method of producing low oxygen
conditions with oxyrase for cultured cells exposed to radiation and tirapazimine. Am J Clin Oncol, 26, E86­E91,
2003.
22. Mikkelsen, RB and Wardman, P. Biological chemistry of reactive oxygen and nitrogen and radiationinduced
signal transduction mechanisms. Oncogene Reviews, 22, 5734­5754, 2003.
23. Amorino GP, Mikkelsen RB, Valerie K, and Schmidt­Ullrich RK. Dominant­negative CREB inhibits
proliferating cell nuclear antigen and DNA repair, leading to increased cellular radiosensitivity. J. Biol. Chem.
278(32), 29394­29399, 2003.
24. Mikkelsen, RB. Redox signaling mechanisms and radiation­induced bystander effects. Human and
Experimental Toxicology, 23, 75­81, 2004.
25. Lammering G, Hewit TH, Holmes M, Valerie K, Hawkins W, Lin PS, Mikkelsen RB, Schmidt­Ullrich RK.
Inhibition of the Type III Epidermal Growth Factor Receptor Variant Mutant Receptor by Dominant­Negative
EGFR­CD533 Enhances Malignant Glioma Cell Radiosensitivity. Clin Cancer Res. 10(19), 6732­6743, 2004.
26. Sturla L­M, Amorino GP, Alexander MS, Mikkelsen RB, Valerie K and Schmidt­Ullrich RK. Requirement of
Tyr992 and Tyr1173 in phosphorylation of the epidermal growth factor receptor by ionizing radiation and
modulation by SHP2, J. Biol. Chem. 280, 14597­604, 2005
27. Barrett, DM, Black SM, Todor H, Schmidt­Ullrich RK, and Mikkelsen, RB. Inhibition of Protein Tyrosine
Phosphatases by Mild Oxidative Stresses is Dependent on S­Nitrosylation, J. Biol. Chem. 280, 14453­14461,
2005.
28. Contessa JN, Abell A, Mikkelsen RB, Valerie K, Schmidt­Ullrich RK. Compensatory ErbB3/c­Src signaling
enhances carcinoma cell survival to ionizing radiation. Breast Cancer Res Treat. Nov 3, 1­11, 2006.
29. Yakovlev VA and Mikkelsen RB A role for CaM­kinases in the cellular response to oxidative stress? Cancer
Biol Ther 5, 1031­2, 2006.
30. Yakovlev VA, Barani IJ, Rabender CS, Black SM, Leach KJ and Mikkelsen RB, Tyrosine Nitration of IkBa:
A novel mechanism for NF­kB activation, Biochemistry, 46 (42), 11671 ­11683, 2007.