PEBC Report - Programa de Epigenética y Biología del Cáncer

PRC1 Polycomb complex that consists of a functional
Ring1B-Bmi1 heterodimer. This E3 ligase activity is required
for maintenance of Polycomb repression in normal- and
cancer stem cells and hence offers potential novel ways to
target cancer stem cells or tumor re-initiating cells in which
the activity of this E3 ligase is hyperactivated. This is further
substantiated by a novel way by which the activity of the
Ring1B.Bmi1 E3 ligase is controlled. The implications of
these findings for stem cell biology, development and cancer
will be discussed.
Selected Publications
Jacobs et al. (1999) Nature 397, 164-8
Jacobs et al. (2000) Nat Genet. 26, 291-99
Lund et al. (2002) Nat Genet. 32, 160-5
Voncken et al. (2003) Proc Natl Acad Sci USA 100, 2468-73
Leung et al. (2004) Nature 428, 337-41
Bruggeman et al. (2005) Genes Dev. 19, 1438-43
Tolhuis et al. (2006) Nat Genet. 38, 694-9
Bruggeman et al. (2007) Cancer Cell 12, 328-41
Uren et al. (2008) Cell 133, 727-41
Pietersen et al. (2008) Curr Biol. 18, 1094-9
30