PEBC Report - Programa de EpigenÃ©tica y BiologÃa del CÃ¡ncer

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PRC1 Polycomb complex that consists of a functional Ring1B-Bmi1 heterodimer. This E3 ligase activity is required for maintenance of Polycomb repression in normal- and cancer stem cells and hence offers potential novel ways to target cancer stem cells or tumor re-initiating cells in which the activity of this E3 ligase is hyperactivated. This is further substantiated by a novel way by which the activity of the Ring1B.Bmi1 E3 ligase is controlled. The implications of these findings for stem cell biology, <strong>de</strong>velopment and cancer will be discussed. Selected Publications Jacobs et al. (1999) Nature 397, 164-8 Jacobs et al. (2000) Nat Genet. 26, 291-99 Lund et al. (2002) Nat Genet. 32, 160-5 Voncken et al. (2003) Proc Natl Acad Sci USA 100, 2468-73 Leung et al. (2004) Nature 428, 337-41 Bruggeman et al. (2005) Genes Dev. 19, 1438-43 Tolhuis et al. (2006) Nat Genet. 38, 694-9 Bruggeman et al. (2007) Cancer Cell 12, 328-41 Uren et al. (2008) Cell 133, 727-41 Pietersen et al. (2008) Curr Biol. 18, 1094-9 30
Presentation of the Cancer Epigenetics and Biology Program (<strong>PEBC</strong>)
Page 3: Cancer Epigenetics and Biology Symp
Page 6 and 7: Foreword by Emilià Pola, IDIBELL G
Page 8 and 9: Sessions of Symposium May 28 th 09:
Page 10: Contents Poster Symposium . . . . .
Page 13 and 14: Speakers Biography and Abstract
Page 15 and 16: SPEAKERS BIOGRAPHY AND ABSTRACT Pet
Page 17 and 18: SPEAKERS BIOGRAPHY AND ABSTRACT Mar
Page 19 and 20: SPEAKERS BIOGRAPHY AND ABSTRACT Ren
Page 21 and 22: SPEAKERS BIOGRAPHY AND ABSTRACT Ext
Page 23 and 24: SPEAKERS BIOGRAPHY AND ABSTRACT Hum
Page 25 and 26: SPEAKERS BIOGRAPHY AND ABSTRACT Pet
Page 27 and 28: SPEAKERS BIOGRAPHY AND ABSTRACT Pie
Page 29 and 30: Michael R Stratton Michael Stratton
Page 31: SPEAKERS BIOGRAPHY AND ABSTRACT Maa
Page 35 and 36: PEBC RESEARCH GROUPS WITH THEIR LEA
Page 37 and 38: Dr Montse Sanchez-Cespedes Genes an
Page 39 and 40: Dr Alejandro Vaquero Chromatin Biol
Page 41 and 42: Dr Esteban Ballestar Chromatin and
Page 43 and 44: Dr Ethel Queralt Cell Cycle Group E
Page 45 and 46: Dr Dave Monk Genomic Imprinting and
Page 47 and 48: Dr Puri Muñoz Aging and Cancer Gro
Page 49 and 50: Dr Eva Gonzalez-Suarez Transformati
Page 55 and 56: PEBC Educational and Training Dimen
Page 57 and 58: PEBC Invited Lectures Professor Mar
Page 59 and 60: PEBC Funding Main Patron Internatio
Page 61 and 62: PEBC Awards and Recognitions Scient
Page 63 and 64: PEBC National Coverage 61
Page 65 and 66: Selected PEBC National and Internat
Page 67: PEBC International Consulting Commi
Page 70: Cancer Epigenetics and Biology Symp
Page 73 and 74: ICC on Tumor Suppressor Genes ICC o

PEBC Report - Programa de EpigenÃ©tica y BiologÃ­a del CÃ¡ncer

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PEBC Report - Programa de EpigenÃ©tica y BiologÃa del CÃ¡ncer