CURICULUM - Purdue College of Pharmacy - Purdue University

CURRICULUM VITAE of Ulrike Dydak, PhD 1
Dr. Ulrike Dydak
Assistant Professor
School of Health Sciences
Purdue University
550 Stadium Mall Drive
West Lafayette, IN 47907
udydak@purdue.edu
Employments
CURICULUM VITAE
Since 2013
Associate Professor, School of Health Sciences, Purdue University, West
Lafayette, IN, USA;
Adjunct Associate Professor of Radiology and Imaging Sciences, Indiana
University School of Medicine. Indianapolis, IN, USA;
Adjunct Associate Professor, Department of Biomedical Engineering, IUPUI,
Indianapolis, IN USA
2007 - 2013 Assistant Professor, School of Health Sciences, Purdue University, West
Lafayette, IN, USA
2008 - 2013 Adjunct Assistant Professor, Department of Biomedical Engineering, IUPUI,
Indianapolis, IN USA
2007 - 2013 Adjunct Assistant Professor of Radiology, Division of Imaging Sciences,
Department of Radiology, Indiana University School of Medicine,
Indianapolis, IN, USA
2005 – 2007 Adjunct Assistant Professor of Health Sciences, Purdue University, IN, USA
2004 - 2008 Member of the board of directors and staff member of GyroTools Ltd:
responsible for MR education (courses, on-site trainings)
2004 – 2007 Research Associate and Project leader of the MR Spectroscopy group at the
Institute for Biomedical Engineering, ETH and University Zürich, Switzerland
July – Aug 2004 Visiting Professor in the Dept. of Radiology at the University of Wisconsin,
Madison, WI, USA
May– June 2004 Visiting Professor in the Dept. of Medical Imaging at the University of
Toronto, Canada
Nov 2003
Co-Founder of the software and education company “GyroTools Ltd”, Zürich,
Switzerland
2002 - 2004 Post-doctoral research fellow at the Institute for Biomedical Engineering,

CURRICULUM VITAE of Ulrike Dydak, PhD 2
University and ETH Zürich; ad-hoc consultant for Philips Medical Systems for
‘on-site’ spectroscopy trainings at various hospitals
1997 – 2002 Research assistant at the Institute for Biomedical Engineering, University and
ETH Zürich, Switzerland
1996 / 97 High School Teacher for Physics and Mathematics in Innsbruck, Austria
University Education
May 2002
Dr.sc.nat (Doctor of Sciences), Federal Institute of Technology Zürich,
Switzerland
PhD thesis:„New approaches to Magnetic Resonance Spectroscopic Imaging of
the Human Brain“
1997-2002 Ph.D. student at the Institute for Biomedical Engineering at the Federal Institute
of Technology (ETH), Zürich, Switzerland
1998-2000 Postgraduate studies in Medical Physics, Federal Institute of Technology
Zürich; Graduation as „Dipl. NDS ETHZ Medizinphysik“ in October 2000;
including training and certificate as expert for radiation protection
July 1996
Mag.rer.nat (combined B.S and M.S.), University of Vienna, Austria;
graduation with honors
1995 - 1996 Diploma Thesis in high energy physics at CERN, Switzerland
Summer 1994
Summer 1993
Summer Student at CERN, Switzerland
Research Assistant at Lawrence Berkeley Laboratory, US
1992 / 93 exchange year at the University of California, Berkeley, US
1990 – 1996 studies in physics (major) and mathematics (minor) at the University of Vienna,
Austria
Awards and Stipends
2011 Outstanding New Environmental Scientist (ONES) Award, NIH/NIEHS
2011 Robert R. Landolt Excellence in Teaching Award
2009 Molecular Imaging Travel Award, Radiological Society of North America
2008 Magna Cum Laude Award for Education Exhibit, Radiological Society of North America
2008 Best Poster Award for Psychiatric Diseases, ISMRM 2008
2005 ASFNR outstanding presentation award at the ASNR 2005
2003 Innovation award of the Swiss Society for Biomedical Engineering
2002 Travel Fellow, Human Brain Mapping Conference 2002, Sendai, Japan
2001 Student travel award, ISMRM 2001, Glasgow

CURRICULUM VITAE of Ulrike Dydak, PhD 3
2000 Poster award, European Society for Magnetic Resonance in Medicine and Biology, Paris
2000 Student travel award, ISMRM 2000, Denver
1997 Fellowship (merit based), University of Vienna
1995 Fellowship (merit based), University of Vienna
Research Grants:
- NIH/NIAMS R21, Co-Investigator, 2012-14
- Purdue University Center for Cancer Research Challenge grant, PI, 2012-2014
- NIH/NIEHS, Outstanding New Environmental Scientist (ONES) Award, R01, PI, 2011-2016
- NIH/NIEHS R21, PI, 2009-2011
- CTSI Core Pilot Funding, PI, 2011-2012
- National Dairy Council, Co-I, 2011-2014
- American Egg Board, Co-I, 2011-2012
- CTSI Core Pilot Funding, PI, 2010-2011
- CTR/CBR Pilot Funding for Translational Research, PI, 2009-2010
- Showalter Grant, Purdue University, PI, 2009
- CTR/CBR Pilot Funding for Translational Research, Co-PI, 2009
- SGR Pilot Funding, IUSM, Co-Investigator, 2008
- Showalter Pilot Funding Grant, IUPUI, Co-Investigator, 2008
- DOD research grant, Co-Investigator, 2008
- Siemens / IU Pilot Funding, PI, 2007-2009
- Medical School Grant, Merck, Co-Investigator, 2003-2006
- Research Grant of the University Zürich, Co-Investigator, 2002-2004
Teaching Activity
♦ Teaching of undergraduate and graduate courses at the School of Health Sciences, Purdue
University, USA:
- Molecular Imaging, Part A: Magnetic Resonance Spectroscopy, 1 CR, spring 2013 –
present
- Radiation Science Fundamentals, 3 CR, distance learning with IU, fall 2010-present
- Radiation Instrumentation Laboratory, 2 CR, spring 2008-2010
- Applied Health Physics, 3 CR, fall 2008-2009
- Magnetic Resonance Spectroscopy, 1 CR, fall 2009 and spring 2011
- Undergraduate and MS research projects (11 undergraduate students and 6 MS students in
past 5 years)
♦ Advising of PhD and MS level students at Purdue University and IUPUI:
Current Advising Activities:
Major Professor (Primary Advisor) for 4 PhD students:
- Scott Jones, Medical Physics/Imaging
- Shalmali Dharmadhikari, Medical Physics/Imaging
- Chien-Lin Yeh, Medical Physics/Imaging
- Ruoyun Ma, Medical Physics/Imaging
Co major Professor for 3 PhD students:

CURRICULUM VITAE of Ulrike Dydak, PhD 4
- Tony Clevenger, Physics, Purdue University
- Victoria Poole, Biomedical Engineering, Purdue University
- Huisi Ai, Medical Physics/Imaging
Member of Advisory Committee for 9 PhD students:
- Stefanie O’Neal, Toxicology, Purdue University
- Yingzi Liu, Medical Physics, Purdue University
- Jing Zhou, Nutrition Sciences, Purdue University
- Katherine Streit, Medical Physics, Purdue Univeristy
- Shiv Srivastava, Medical Physics, Purdue University
- Akshay Verleker, Medical Physics, Purdue University
- Wu Junqing, Medical Physics, Purdue University
- James Sivley, Nutrition Sciences, Purdue University
- Chungwein Lee, Medical Physics, Purdue University
Past Advising Activities:
Since 2008 I graduated 2 PhD student as major advisor, 6 MS students as major professor,
2 PhD students as Co-major professor, 2 MS students as Co-major professor and 8 PhD
students as well as 18 MS students as member of their advisory committee
♦ Teaching in the Imaging Sciences Educational Workshop and the Clinical MRI Education
Lectures (CME credit) at IU School of Medicine
♦ Lecturer at ISMRM Weekend Educational Courses (CME credit), 2008 & 2009
♦ Teaching activity for GyroTools (http://www.gyrotools.com/courses/) :
• International MRS Application Course in Zuerich (yearly), since 2004
• On-site trainings, since 2004
♦ Lecturer at the annual Course in Magnetic Resonance Spectroscopy, International Zurich
Magnetic Resonance Education Center, 1998- 2006
♦ Lecturer at the annual Advanced Spectroscopy Course at Philips Medical Systems, Cleveland,
US, 2005, 2006
♦ Guest lecturer at the University of Wisconsin, Madison (summer lecture series on MR
Spectroscopy), 2004
♦ Lecturer at the Spectroscopy Application Workshops at Philips Medical Systems, Best, The
Netherlands, 2002-2004
♦ On-site MR Spectroscopy Trainings, as consultant for Philips /GyroTools from 2001-2004
♦ Lecturer at the ETH Zurich on ‘Statistics in Biomedical Engineering’ (part of the course
‘Biomedical Engineering I’), 2000 & 2001, 4h/course
♦ Teaching Assistant for Medical Physics at the ETH Zurich, Switzerland, since 1997

CURRICULUM VITAE of Ulrike Dydak, PhD 5
♦ Advisor of Master’s students from the ETH Zurich and medical PhD students from the
University Zürich, Switzerland, since 1998
♦ High School Teaching (Physics and Mathematics), Innsbruck, Austria, 1996-1997
Memberships
- ad hoc member of MEDI Study Section NIH/NIBIB
- International Society for Magnetic Resonance in Medicine (ISMRM)
- German Chapter of the International Society for Magnetic Resonance in Medicine
- Society of Toxicology (SOT)
- Purdue Center for Cancer Research (PUCCR)
- past membership: International College of Neuropsychopharmacology (CINP)
Review for journals
- Magnetic Resonance in Medicine (MRM), regular reviews since 2004
- Neuroradiology, regular reviews since 2006
- Brain Imaging and Behavior, 2007, 2012
- Magnetic Resonance Imaging, 2008, 2009, 2011, 2012
- Neurotoxicology, 2009
- Cephalalgia, since 2009
- J. of Occup. And Environm. Medicine, 2009
- NMR in Biomedicine, since 2010
- Toxicological Sciences, 2010, 2012
- Journal of Cerebral Blood Flow and Metabolism, 2011
- Cell Biology and Toxicology, 2011
- PLoS ONE, 2011
- Journal of Magnetic Resonance Imaging, 2012
- Frontier in Neuroscience, 2013
List of Publications:
1. Xu, J, Dydak U, Harezlak J, Nixon J, Dzemidzic M, Gunn A.D., Karne H.S., Anand A (2013).
Neurochemical Abnormalities in Unmedicated Bipolar Depression and Mania: a 2D 1H MRS
Investigation. Submitted to Psychiatry Research: Neuroimaging (in press)
2. Shin YW, Dzemidzic M, Jo HJ, Long Z, Medlock C, Dydak U, Goddard AW (2013).
Increased resting-state connectivity between the anterior cingulate cortex and the precuneus in
panic disorder. J Affect Disord. 2013 May 17. doi:pii: S0165-0327(13)00299-1.
10.1016/j.jad.2013.04.026, PMID: 23688914
3. Long Z, Medlock C, Dzemidzic M, Shin YW, Goddard A, Dydak U (2013). Decreased
GABA levels in Anterior Cingulate Cortext/Medial Prefrontal Cortex in Panic Disorder. Prog
NeuroPsychopharmacol Biol Psychiatry. Epub 2013 Feb 4., doi:pii: S0278-5846(13), PMID:
23391588

CURRICULUM VITAE of Ulrike Dydak, PhD 6
4. Panda A, Jones S, Raghavan RS, Sandrasegaran K, Bansal N, Dydak U (2012). Phosphorus
Liver MRSI at 3T Using a Novel Dual Tuned 8-Channel 31P/1H Coil. Magnetic Resonance in
Medicine 68:1346-56 PMCID 22287206
5. Racette B.A., Aschner M, Guilarte TR, Dydak U, Criswell SR, Zheng W (2012).
Pathophysiology of Manganese-Associated Neurotoxicity. Neurotoxicology 33(4):881-6.
PMID: 22202748
6. Dydak U, Jiang YM, Long LL, Zhu H, Chen J, Li WM, Edden RAE, Hu S, Fu X, Long Z,
Meier D, Harezlak J, Aschner M, Murdoch JB, Zheng W. In Vivo Measurement of Brain
GABA Concentrations by Magnetic Resonance Spectroscopy in Smelters Occupationally
Exposed to Manganese. Environ Health Perspect.119:219-224, 2011. Epub 2010 Sep 28.
PMID: 20876035
7. Zheng W, Fu X, Dydak U, Cowan DM. Biomarkers of Manganese Intoxication.
Neurotoxicology 32:1-8, 2011.
8. Poryazova R, Schnepf B, Werth E, Khatami R, Dydak U, Meier D, Boesiger P, Bassetti CL.
Further Evidence for Hypothalamo-Amygdala Dysfunction in Narcolepsy. Sleep.
2009;32(5):607-13. PMID: 19480227.
9. Walter M, Henning A, Grimm S, Schulte RF, Beck J, Dydak U, Schnepf B, Boeker H,
Boesiger P, Northoff G. The Relationship between aberrant Neuronal Activation Patterns in
the Pregenual Anterior Cingulate, Altered Glutamatergic Metabolism and Anhedonia in Major
Depression. Arch Gen Psychiatry 2009;66(5):478-86. PMID: 19414707
10. Henning A, Schär M, Kollias S, Boesiger P, Dydak U. Quantitative magnetic resonance
spectroscopy in the entire human cervical spinal cord and beyond at 3T. Magn Reson Med.
2008;59(6):1250-8. PMID: 18421679
11. Northoff G, Walter M, Schulte RF, Beck J, Dydak U, Henning A, Boeker H, Grimm S,
Boesiger P. GABA concentration in the human anterior cingulate cortex predicts negative
BOLD response in fMRI. Nature Neuroscience;10(12):1515-7, 2007. Epub 2007 Nov 4.
PMID: 17982452
12. Schoonman GG, Sándor PS, Nirkko AC, Lange T, Jaermann T, Dydak U, Kremer C, Ferrari
MD, Boesiger P, Baumgartner RW. Hypoxia-induced acute mountain sickness is associated
with intracellular cerebral edema: a 3T magnetic resonance imaging study. J Cereb Blood
Flow Metab. 28(1):198-206, 2008. Epub 2007 May 23. PMID: 17519973
13. Dydak U, Schär M. MR Spectroscopy and Spectroscopic Imaging: Comparing 3.0T versus
1.5T. Review Article. Neuroimaging Clin N Am 16(2):269–283, 2006. PMID: 16731366
14. Dydak U, Mueller S, Sandor PS, Meier D, Boesiger P, Jung HH. Cerebral Metabolic
Alterations in McLeod Syndrome. Eur Neurol 56(1):17-23, 2006. PMID: 16914926
15. Dydak U, Meier D, Lamerichs R, Boesiger P. Trading Spectral Separation at 3T for
Acquisition Speed in Multi Spin-Echo Spectroscopic Imaging. AJNR Am J Neuroradiol.
27(7):1441-6, 2006. PMID: 16908554
16. Lange T, Dydak U, Roberts TP, Rowley HA, Bjeljac M, Boesiger P. Pitfalls in Lactate
Measurements at 3T. AJNR Am J Neuroradiol. 27(4):895-901, 2006. PMID: 16611787

CURRICULUM VITAE of Ulrike Dydak, PhD 7
17. Lange T, Trabesinger AH, Schulte RF, Dydak U, Boesiger P. Prostate spectroscopy at 3 Tesla
using two-dimensional S-PRESS. Magn Reson Med. 56(6):1220-8, 2006. PMID: 17094089
18. Sánchez-Gonzales J, Tsao J, Dydak U, Desco M, Boesiger P, Pruessmann KP. Minimum-
Norm Reconstruction for Sensitivity-Encoded MR Spectroscopic Imaging. Magn Reson Med.
55(2):287-95, 2006. PMID: 16408281
19. Trabesinger AH, Meier D, Dydak U, Lamerichs R, Boesiger P. Optimizing PRESS Localized
Citrate Detection at 3 Tesla. Magn Reson Med. 54(1):51-58, 2005. PMID: 15968673
20. Sándor PS, Dydak U, Schoenen J, Kollias SS, Hess K, Boesiger P, Agosti M. MR-
Spectroscopic Imaging during visual stimulation in subgroups of migraine with aura,
Cephalalgia 25(7):507-518, 2005. PMID: 15955037
21. Dydak U, Pruessmann KP, Weiger M, Tsao J, Meier D, Boesiger P. Parallel Spectroscopic
Imaging with Spin-Echo Trains, Magn Reson Med. 50(1): 196-200, 2003. PMID: 12815695
22. Dydak U, Weiger M, Pruessmann KP, Meier D, Boesiger P. Sensitivity-Encoded
Spectroscopic Imaging, Magn Reson Med. 46(4): 713-722, 2001. PMID: 11590648
23. Do KQ, Trabesinger AH, Kirsten-Krüger M, Lauer CJ, Dydak U, Hell D, Holsboer F,
Boesiger P, Cuénod M; Schizophrenia: Glutathione Deficit in Cerebrospinal Fluid and
Prefrontal Cortex in Vivo. Eur J Neurosci 12(10), 3721-3728, 2000. PMID: 11029642
24. Ambuehl PM, Meier D, Wolf B, Dydak U, Boesiger P, Binswanger U; Metabolic Aspects of
Phosphate Replacement Therapy for Hypophosphatemia After Renal Transplantation: Impact
on Muscular Phosphate Content, Mineral Metabolism, and Acid/Base Homeostasis. Am J
Kidney Dis 34(5), 875-883, 1999. PMID: 10561144
Patents:
Van den Brink JS, Weiger M, Dydak U, Folkers PJM, Lamerichs RMJN, Pruessmann KP,
VanMuiswinkel AMC. Magnetic Resonance Imaging Method with Sub-Sampling. International
Publication number: WO 00/72034 A1, 30.11.2000.
Invited Talks
(italic: invited talks at major international conferences)
2012 The Indianapolis Chapter of the Society of Neuroscience, Annual Meeting, “In Vivo
Assessment of GABA Brain Levels in Parkinson-like Motor Disorders by MRS”,
Indianapolis, IN, USA, Sept 28, 2013
2012 Symposium of the Women’s Global Health Institute, “How can MRI help us to detect
toxic exposure to the brain of individualize treatment in liver cancer?”, Purdue
University, West Lafayette, IN, USA, Sept 27, 2013
2012 CINP, Symposium on Panic Disorder, “GABA Imaging Findings in Panic Disorder
measured by 1H MRS”, Stockholm, Sweden, June 3, 2012

CURRICULUM VITAE of Ulrike Dydak, PhD 8
2012 International Symposium on Exposure to Manganese and Neurotoxicity in Welders,
“Neuroimaging – quantification of Mn, Fe and metabolites (by MRS) in the brain”,
Bochum, Germany, May 9, 2012
2012 PUCCR Research Seminar, West Lafayette, IN, USA, April 26, 2012
2011 Parkinson Patient Support Group, “Neuroimaging of Manganese-Induced
Parkinsonism”, West Lafayette, Nov 10, 2011
2011 Purdue University Center for Cancer Research (PUCCR) Scientific Retreat, “In Vivo
31P Magnetic Resonance Spectroscopy: Monitoring the Liver's Response to Radiation
Treatment”, West Lafayette, IN, USA, Sept 8, 2011
2011 Xi’an International Neurotoxicology Conference, “In vivo Assessment of GABA and
Glutamate levels by Magnetic Resonance Spectroscopy in Manganese Exposure“, Xi’an,
China, June 9, 2011
2011 Chronic Disease Research Interest Group Seminar Series, Purdue, “Neuroimaging of
Manganese-Induced Parkinsonism“, West Lafayette, IN, USA, Apr 18, 2011
2011 Interdepartmental Nutrition Program Seminar, Purdue University, “Measuring
Metabolism with Magnetic Resonance Spectroscopy”, West Lafayette, IN, USA, Jan 14,
2011
2010 CANMRDC 2010 Meeting, University of Illinois, “In Vivo Measurement of
Neurotransmitters by MRS”, Urbana-Champaign, IL, USA, Nov 6, 2010.
2010 Seminar, Department of Radiology & Radiological Science, Johns Hopkins University
School of Medicine, “MR Spectroscopy of GABA and 3D MRI in Smelters Exposed to
Manganese”, Baltimore, MD, USA, April 2, 2010
2010 Analytical Chemistry Seminar, Purdue University, “From NMR to MRS: Measuring
Neurotransmitter Concentrations in the Living Brain“, Chemistry Department Purdue,
Feb 9, 2010
2010 Research Seminar, MRI group, Medical University of Vienna, Austria, “Liver 31P MRSI
Using an 8-Channel Dual-Tuned 31P/1H Coil at 3T”, Vienna, Austria, Jan 18, 2010
2009 Manganese Health Research Program Showcase Conference, “Spectroscopy of GABA
and 3D MRI in Smelters exposed to Manganese”, Lansdowne, VI, USA, June 24-25
2009
2009 ISMRM Weekend Educational Courses, Imaging Strategies, “Spectroscopic Imaging:
Implementation and Acceleration”, ISMRM, Honolulu, USA, April 19 th , 2009
2009 Medical Physics Mini-Symposium. Purdue University/Indiana University School of
Medicine, “Monitoring the Response of Liver Cancer to Radiation Therapy by means of
1H and 31P MRS”, January 24 th , 2009

CURRICULUM VITAE of Ulrike Dydak, PhD 9
2008 International Mini-Symposium on Parkinsonian Diseases, Purdue University, "MRI and
MRS in Manganese Exposed Smelters", Oct 2008
2008 ISMRM, Educational Course, Toronto, Canada, “Spectroscopic Imaging:
Implementation and Acceleration”, May 4, 2008
2008 Indiana Neuroimaging Symposium, Indianapolis, IN, USA, “Methods Blitz: MRS”,
April 25, 3008
2008 Center for Magnetic Resonance Research, University of Minnesota, MN, USA, “SENSE
and long Echo Trains: Fast, Parallel, and dynamic MRSI”, February 14, 2008
2007 ISMRM High Field Workshop, Asilomar, CA, USA, “Clinical Impact of Parallel
Imaging at 3T” (March 25-28)
2006 Grand Rounds and lecture series, Radiology Department, University of Wisconsin,
Madison, WI, USA: “Basics of MR Spectroscopy”, “MRS at 3T: New Possibilities and
Challenges”, “SENSE and Long Echo Times: Fast, Parallel and Dynamic MRSI”
2006 14 th Meeting of the ISMRM, Seattle, WA, USA, Lunchtime Symposium Philips Medical
Systems
2005 13 th Meeting of the ISMRM, Miami, FL, USA. Course on MR physics and Techniques for
clinicians: "MR Spectroscopy"
2005 46 th Experimental Nuclear Magnetic Resonance Conference, Providence, RI, USA,
"Sensitivity Encoded Spectroscopic Imaging"
2005 Seminar at Vanderbilt University Institute of Imaging Science (VUIIS), Nashville, TN,
USA, “MR Spectroscopic Imaging: Faster and Functional at 3T”
2005 Philips Neuro Council Meeting, Groenendael, The Netherlands. "Functional
Spectroscopic Imaging of the Human Brain"
2004 Second International Workshop on Parallel MRI, Zurich, Switzerland. "Parallel
Spectroscopic Imaging"
2004 National Italian Congress of Neuroradiology (AINR), Milan, Italy. "Motivation for 3T:
methodological aspects"
2004 Grand Rounds, Department of Neurology, University of Wisconsin, Madison, WI, USA.
"fMRI and MRS in Migraine"
2004 Grand Rounds, Department of Radiology, University of Wisconsin, Madison, WI, USA.
"Frontiers in MR Spectroscopic Imaging: Fast, parallel and dynamic"

CURRICULUM VITAE of Ulrike Dydak, PhD 10
2004 Neurosciences Rounds, University of Toronto, Toronto, Canada. "Magnetic Resonance
Spectroscopic Imaging: Faster and Functional"
2004 42 nd Annual Meeting of the American Society of Neuroradiology, Seattle, USA,
Advanced Imaging Seminar: ‘Advanced MRSI Techniques’
2004 Radiology Seminar, University Hospital Lund, ‘MRI and MRS at 3T: advantages and
pitfalls’
2003 MR Colloquium, Amsterdam Medical Center, The Netherlands, ‘MRS and MRI at 3T:
promises and pitfalls’
2003 Wednesday morning lecture, Philips Medical Systems, Best, The Netherlands, ‘Parallel
Spectroscopic Imaging: SENSE-SI’
2003 41 st Annual Meeting of the American Society of Neuroradiology, Washington DC, USA,
‘MRSI: Faster and Functional’
2003 1 st Philips Radiology MR Network Meeting, Antwerp, Belgium, ‘Ultrafast SENSE-TSI
and 3D SI at 3T’
2003 1 st Philips Radiology MR Network Meeting, Antwerp, Belgium, ‘Functional
Spectroscopic Imaging in Migraine: Problems of detecting Lactate at 3T and solutions’
2003 Physics Seminar, J.W.Goethe-University, Frankfurt, Germany, ‘Ein Blick in den
Gehirnstoffwechsel: Neue Methoden in der Magnetresonanz Spektroskopie’
2003 Minisymposium SEP on Advanced Functional Neuroimaging, Zürich, Switzerland,
‘Functional Spectroscopy in Migraine’
2002 Panorama MediClinic, Capetown, South Africa, ‘Clinical Applications of MR
Spectroscopy’
2002 Imaging Physics Colloquium, Department of Medical Imaging, University of Toronto,
Canada, ‘MR Spectroscopic Imaging: faster and functional’
2002 Scientific Retreat on “High field in vivo MR”, Goesing, Austria, ‘Parallel Imaging at 3T’
2002 Meeting of the British Institute of Radiology on Recent Advances in MR Spectroscopy
of Disease, Manchester, UK, ‘Applications of SENSE based Spectroscopy Techniques’
2002 First Philips Neuro and 3.0 T User Meeting, Philips Medical Systems, The Netherlands,
’SENSE and Spectroscopic Imaging’
2001 MR Colloquium, University Hospital Geneva, Switzerland, ‘New Techniques in

CURRICULUM VITAE of Ulrike Dydak, PhD 11
Spectroscopic Imaging’
2001 MR Colloquium, Amsterdam Medical Center, The Netherlands, ‘SENSE: Basics and
Applications’
2000 MR Colloquium, VA Medical Center San Francisco, ‘SENSE: Sensitivity Encoding for
faster MRI and MRSI’
2000 fMRI Colloquium, Departments of Neuroradiology, University Hospital Zurich,
Switzerland, ‘Cortical Lactate Changes during prolonged visual stimulation in migraine’
Conference Presentations:
2013
Ward E, Rosenthal F, Zimmerman N, Dydak U. Manganese Exposure Assessment – The Use of
Toenails as Biomarker of Manganese Exposure. Annual Meeting AIHCE, Montreal, Canada,
May 18-23, 2013.
Dharmadhikari S, McGlothan JL, Edden R, Barker PB, Schneider J, Dydak U, Guilarte TR.
Neurochemical Alterations in Non-human Primates Following Manganese- exposure: A 1H
Magnetic Resonance Spectroscopy Study, Campbell-Klatte Annual Symposium, Indianapolis,
Indiana, May 21, 2013.
Clevenger T, Panda A, Jones S, Sandrasegaran K, Cardenes H, Dydak U. 31P MRSI as an Early
Indicator of Response to Radiation Treatment in Liver Cancer. ISMRM 20th Scientific Meeting
& Exhibition, Salt Lake City, UT, USA, April 20-26 2013. Proc. Intl. Soc. Mag. Reson. Med.
21:5896
Dharmadhikari S, Dydak U, Dzemidzic M, Romito L, Byrd K. Single voxel MEGA-edited
GABA and short TE 1H MRS in hippocampus and other brain regions implicated in bruxism.
ISMRM 20th Scientific Meeting & Exhibition, Salt Lake City, UT, USA, April 20-26 2013.
Proc. Intl. Soc. Mag. Reson. Med. 21:4185
Long Z, Jiang Y-M, Li X-R, Xu J, Long LL, Zheng W, Murdoch JB, Dydak U. GABA levels
correlates with occupational manganese exposure and motor tests in smelters. ISMRM 20th
Scientific Meeting & Exhibition, Salt Lake City, UT, USA, April 20-26 2013. Proc. Intl. Soc.
Mag. Reson. Med. 21:2120
Long Z, Jiang YM, Li XR, Xu J, Long LL, Zheng W, Murdoch JB, Dydak U. Comparison of
Brain Metabolite Changes in Manganese-exposed Welders and Smelters. ISMRM 20th
Scientific Meeting & Exhibition, Salt Lake City, UT, USA, April 20-26 2013. Proc. Intl. Soc.
Mag. Reson. Med. 21:2128,
Poole V, Leverenz L, Nauman E, Talavage T, Dydak U. 1H MRS Suggests Chronic and Acute
Injury in High School Football Players. ISMRM 20th Scientific Meeting & Exhibition, Salt Lake
City, UT, USA, April 20-26 2013. Proc. Intl. Soc. Mag. Reson. Med. 21:4317, Abstract
Dharmadhikari S, McGlothan JL, Edden R, Barker P, Schneider J, Guilarte TR, Dydak U,
Guilarte TR. Neurochemical alterations in the non-human primate brain during chronic
exposure to manganese: a 1H MRS study. Society of Toxicology 52nd Annual Meeting, San
Antonio, TX, USA, March 10-14 2013. Toxicol Sci suppl. 132(1):1866

CURRICULUM VITAE of Ulrike Dydak, PhD 12
Long Z, Jiang YM, Li XR, Xu J, Long LL, Zheng W, Murdoch JB, Dydak U. Elevated Regional
Signal Intensity Indices in Mn-exposed Welders. SOT Annual Meeting, San Antonio, TX, USA,
March 10-14 2013.
Dharmadhikari S, Yeh CL, McGlothan JL, Edden R, Barker P, Schneider J, Guilarte TR, Dydak
U, Guilarte TR. MRI and 1H MRS evaluation of chronic manganese exposure in non-human
primates. AAPM ORVC Spring Educational Symposium, March 1-2, 2013.
2012
Dharmadhikari S, Dydak U, Dzemidzic M, Romito L, Byrd K. Quantification of GABA and other
metabolite levels in brain regions implicated in PTSD, temporomandibular disorder, and
traumatic brain injury. Poster presentation at Society for Neuroscience, New Orleans, USA, Oct
13-17 2012.
Poole VN, Breedlove E, Robinson M, Breedlove K, Leverenz L, Nauman E, Dydak U, Talavage
T. Asymptomatic High School Contact Sports Athletes exhibit metabolic changes that correlate
with head collision history. Poster presentation at Society for Neuroscience, New Orleans, USA,
Oct 13-17 2012. (Best Poster Award to Ms. Poole at Indianapolis Society for Neuroscience
meeting, Sept 28, 2012)
Brander WS, Jones SR, Conley TB, Sayer D, Zhou J, Fisher S, Dydak U, Campbell WW.
Changes in Estimated of Muscle Lipid Contamination Following Transition from Standing to
Supine. Ohio River Valley Chapter of AAPM meeting, Indianapolis, IN, Oct 12, 2013.
Jones S, Panda A, Cardenes Hm Fletcher J, Hutchins G, Dydak U.Spatially Resolved Evaluation
of Radiation Induced Metabolic Response in Normal and Malignant Liver with 3D 31P MRSI.
Purdue University Center for Cancer Research (PUCCR) Scientific Retreat, West Lafayette,
IN, USA, Sept 13, 2013.
Clevenger T, Panda A, Jones S, Dydak U. Accelerated 31P Liver Magnetic Resonance
Spectroscopic Imaging. Purdue University Center for Cancer Research (PUCCR) Scientific
Retreat, West Lafayette, IN, USA, Sept 13, 2013.
Panda A, Heberlein K, Neji R, Dydak U. Implementing GRAPPA for fast 2D MRSI on Siemens
MAGNETOM Trio. Oral presentation at American IDEA User Group Meeting, Utah Center
for Advanced Imaging Research, Salt Lake City, UT, June 4-6 2012.
Panda A, Jones S, Raghavan RS, Heberlein K, Neji R, Dydak U. Accelerated In-vivo Liver 31P
MRSI using GRAPPA. Accepted for presentation at ISMRM 20th Scientific Meeting &
Exhibition, Melbourne, Australia, May 5-11 2012. Proc. Intl. Soc. Mag. Reson. Med. 20:4422.
Xu J, West JD, Saykin AJ, Dydak U. “Assessment of automated brain region directed 3D proton
spectroscopy data analysis pipeline”, accepted for presentation at ISMRM 20 th Scientific
Meeting & Exhibition, Melbourne, Australia, May 5-11, 2012.
Xu J, Brenna CM, West JD, Dydak U, Saykin AJ. “3D MRSI of brain neurochemical changes in
breast cancer patients treated with chemotherapy”, accepted for presentation at ISMRM 20 th
Scientific Meeting & Exhibition, Melbourne, Australia, May 5-11, 2012.

CURRICULUM VITAE of Ulrike Dydak, PhD 13
Long Z, Xu J, McGlothan JL, Edden R, Barker P, Guilarte TR, Dydak U. Baseline Comparison of
Brain Metabolites between Rhesus Monkeys and Humans by MRS. accepted for presentation at
ISMRM 20 th Scientific Meeting & Exhibition, Melbourne, Australia, May 5-11, 2012. Proc.
Intl. Soc. Mag. Reson. Med. 20:4435.
Jones S, Panda A, Cardenes H, Fletcher J, Hutchins G, and Dydak U. A Spatially Resolved
Evaluation of Radiation Induced Metabolic Response in Normal and Malignant Liver with 3D
31P MRSI, accepted for presentation at ISMRM 20 th Scientific Meeting & Exhibition,
Melbourne, Australia, May 5-11, 2012. Proc. Intl. Soc. Mag. Reson. Med. 20: 1536.
Panda A, Jones S, Dydak U. Implementation of GRAPPA Algorithm for Fast 2D 31 P Liver MRSI.
Oral presentation at 37th Annual Campbell-Klatte Lecture Series, Indianapolis, IN, April 17
2012. (Best presentation award 1 st Place to Mr. Panda)
Jones S, Panda A, Dydak U. A Spatially Resolved Evaluation of Radiation Induced Metabolic
Response in Normal and Malignant Liver with 3D 31 P MRSI. Oral presentation at 37th Annual
Campbell-Klatte Lecture Series, Indianapolis, IN, April 17 2012.
Dharmadhikari S, Xu J, Epur A, Zheng W, Dydak U. Increased cortical GABA levels in
Manganese-treated rats. SOT Annual Meeting, San Francisco, USA, March 11-15 2012.
Long Z, Xu J, McGlothan JL, Edden R, Barker P, Guilarte TR, Dydak U. Baseline Comparison of
Brain Metabolites between Rhesus Monkeys and Humans by MRS, SOT Annual Meeting, San
Francisco, USA, March 11-15, 2012.
Long Z, Jiang YM, Li XR, Xu J, Long LL, Zheng W, Murdoch J, Dydak U. Comparison of Brain
Metabolite Changes in Manganese-exposed Welders and Smelters, accepted for presentation at
SOT Annual Meeting, San Francisco, USA, March 11-15, 2012.
2011
Panda A, Jones S, Sandrasegaran K, Dydak U. Efficacy of ³¹P MRS in Evaluation of
Hepatocellular Carcinoma Response to Targeted Radiation Therapy. Radiological Society of
North America (RSNA) Annual Meeting, Chicago, IL, USA, Nov 27-Dec 2 2011.
Jones S, Panda A, Dydak U. 31 P MRSI of Human Liver metabolism: Bridging the Gap between
Therapy and Diagnostic Imaging, PUCCR Annual Scientific Retreat, West Lafayette, IN, USA,
Sept 8, 2011
Long Z, Xu J, Li XR, Long LL, Jiang YM, Zheng W, Dydak U. Neuroimaging of Brain
Manganese and GABA as Biomarkers of Occupational Manganese Exposure. Xi’an Internation
Neurotoxicology Conference, Xi’an, China, June 5-11, 2011 (oral presentation).
Dydak U, Xu J, Epur A, Li XR, Streitmatter S, Long LL, Zheng W. Jiang YM. Brain Regions
showing Manganese Accumulation in the Human versus the Rat Brain. Accepted for
presentation at ISMRM 29 th Scientific Meeting & Exhibition, Montreal, Canada, May 7-13,
2011. Proc. Intl. Soc. Mag. Reson. Med. 19:239 (oral presentation)
Dydak U, Xu J, Marjanska M, Posse S. 3D GABA Spectroscopic Imaging using MEGA-PEPSI.
Accepted for presentation at ISMRM 29 th Scientific Meeting & Exhibition, Montreal, Canada,
May 7-13, 2011. Proc. Intl. Soc. Mag. Reson. Med. 19:1428

CURRICULUM VITAE of Ulrike Dydak, PhD 14
Jones S, Panda A, Dydak U. Whole Liver 31 P Metabolite Mapping with 3D CSI. Accepted for
presentation at ISMRM 29 th Scientific Meeting & Exhibition, Montreal, Canada, May 7-13,
2011. Proc. Intl. Soc. Mag. Reson. Med. 19:1429
Murdoch JB, Dydak U. Modeling MEGA-PRESS macromolecules for a better grasp of GABA.
Accepted for presentation at ISMRM 29 th Scientific Meeting & Exhibition, Montreal, Canada,
May 7-13, 2011. Proc. Intl. Soc. Mag. Reson. Med. 19:1394.
Long Z, Murdoch JB, Goddard AW, Dydak U. Do Cortical GABA Levels Correlate with Age?
Accepted for presentation at ISMRM 29 th Scientific Meeting & Exhibition, Montreal, Canada,
May 7-13, 2011. Proc. Intl. Soc. Mag. Reson. Med. 19:4054
Long Z, Murdoch JB, Xu J, Dydak U. GABA Fitting for MEGA-PRESS Sequences with
Different Selective Inversion Frequencies. Accepted for presentation at ISMRM 29 th Scientific
Meeting & Exhibition, Montreal, Canada, May 7-13, 2011. Proc. Intl. Soc. Mag. Reson. Med.
19:1399 (ISMRM student travel award to Z. Long)
Conley T, Jones S, Dydak U, Talavage T, Tamer G, Grindle M, Campbell W. Reseach Imaging
Techniques to Assess Human Skeletal Muscle Size and Composition. Indiana CTSI 3rd Annual
meeting, April 25 2011.
Poole V, Talavage T, Dydak U. Reproducibility of Metabolite Quantification in the College
Student Brain. Poster Presentation at Interdisciplinary Graduate Program Spring Reception,
Purdue University, April 20, 2011.
Long Z, Jiang YM, Li XR, Xu J, Long LL, Zheng W, Dydak U. Neuroimaging of Manganese
Toxicity: GABA and Metabolic Changes in the Human Brain. SOT Annual Meeting,
Washington D.C., USA, March 6-10 2011. Toxicol Sci suppl.
Xu J, Li XR, Jun X, Streitmatter S, Long LL, Zheng W, Jiang YM, Dydak U. Neuroimaging of
Manganese Toxicity: Effect of Exposure Time on Mn Accumulation in the Human Brain. SOT
Annual Meeting, Washington D.C., USA, March 6-10 2011. Toxicol Sci suppl.
Epur A, Xu J, Zheng W, Dydak U. Neuroimaging of Manganese Toxicity: Therapeutic Effect of
Para-Aminosalicylic Acid in a Rat Model. SOT Annual Meeting, Washington D.C., USA,
March 6-10 2011. Toxicol Sci suppl.
Panda A, Dydak U. Clinical Challenges in Implementing 31P MR Spectroscopy of Focal Liver
Lesions. AAPM Ohio River Valley Spring 2011 Educational Symposium, Cincinnati, OH, USA,
March 3-4, 2011. (oral presentation)
Jones S, Panda A, Dydak U. Whole Liver 31 P Metabolite Mapping with 3D CSI. AAPM Ohio
River Valley Spring 2011 Educational Symposium, Cincinnati, OH, USA, March 3-4, 2011.
2010
Goddard A, Dydak U, Long Z, Medlock C, Shekhar A, McDougle C. The Effect of Family
History of Panic on Cortical GABA Deficits in Panic Disorder: a Prospective 1H-MRS Study.
Americal College of Neuropsychopharmacology 49 th annual meeting, Miami Beach, FL, USA,
Dec 5-9,2010
Xu J, Dydak U, Posse S. Fast GABA Mapping in Human Brain with MEGA-PEPSI at 3 Tesla.
(talk) Radiological Society of North America Annual Meeting, Chicago, IL, USA, Nov 28-Dec
3, 2010

CURRICULUM VITAE of Ulrike Dydak, PhD 15
Panda A, Jones SR, Sandrasegaran K, Dydak U. Monitoring Response of Liver Cancer to
Targeted Radiation Therapy with a Novel 31P/1H MRS Coil, 2010 AAPM Annual Meeting,
Philadelphia, PA, USA, July 18-22, 2010 (oral presentation)
Dydak U, Marjanska M, Posse S. High-Speed GABA Mapping in Human Brain with MEGA-
PEPSI at 3 Tesla. ISMRM 18th Scientific Meeting & Exhibition, Stockholm, Sweden, May 1-7,
2010. Proc. Intl. Soc. Mag. Reson. Med. 18:961
Dydak U, Nixon JM, Dzemidzic M, Karne HS, Anand A. Metabolic Changes in Medication-free
Patients with Bipolar and Unipolar Disorder. ISMRM 18th Scientific Meeting & Exhibition,
Stockholm, Sweden, May 1-7, 2010.
Panda A, Jones SR, Dydak U. Reproducibility Evaluation of Spatially Resolved Liver 31P
Metabolism Using a Dual Tuned 8-channel 31P/1H Coil. ISMRM 18th Scientific Meeting &
Exhibition, Stockholm, Sweden, May 1-7, 2010.
Yoshimoto Ninamango EQ, Zhao C, Yung K-T, Zheng W, Ackley E, Dager S, VanMeter J,
Dydak U, Heberlein K, Tsai S-Y, Lin F-H, Wald L, Van Der Kouwe1 A, Bustilo J, Posse S.
3D High Spatial Resolution Short TE Proton-Echo-Planar-Spectroscopic-Imaging (PEPSI) at
3T in Clinically Feasible Measurement Times. ISMRM 18th Scientific Meeting & Exhibition,
Stockholm, Sweden, May 1-7, 2010.
Nixon J, Dydak U, Dzemidzic M, Karne H, Anand A. Magnetic Resonance Spectroscopy
Imaging of Differences Between Unmedicated Bipolar and Unipolar Depression. Society of
Biological Psychiatry, 65th Annual Scientific Convention, New Orleans, LO, USA, May 20-22,
2010.
Panda A.m Sandrasegaran K, Dydak U. Assessment of 31P Magnetic Resonance Spectroscopy in
Predicting Early Response to Embolic or Anti-Angiogenic Therapy of Liver Malignancies.
Indiana CTSI Annual Meeting, April 19, 2010.
Dydak U, Jiang Y, Long Z, Long L, Chen J, Harezlak J, Zhu H, Aschner M; Murdoch J, Zheng
W. GABA Increases in Basal Ganglia in Manganese Exposed Smelters. SOT Annual Meeting,
Salt Lake City, UT, USA, March 7-10 2010. Toxicol Sci suppl. 114(1): 1000.
2009
Dydak U, Yoder K. How to Measure Neurotransmitters with MRS and PET: Focus on GABA,
Glutamate, and Dopamine (Educational Exhibit). Radiological Society of North America
Annual Meeting, Chicago, IL, USA, Nov 29-Dec 4 2009. (Molecular Imaging Travel award)
Dydak U, Long L, Zhu H, Li WM, Jiang Y, Chen J, Fu X, Hu S, Edden RAE, Meier D, Aschner
M, Murdoch J, Zheng W. Assessment of Neurotransmitter Concentrations in Occupational
Manganese Exposure as measured by MRS. ISMRM 17th Scientific Meeting & Exhibition,
Honolulu, Hawai'i, USA 18-24 April 2009.
Raghavan RS, Panda A, Valette J, James JR, Heberlein K, Boettcher U, Henry PG, Bansal N,
Dydak U. Liver 31 P MRSI Using an 8-Channel Dual-Tuned 31 P/ 1 H Coil at 3T, ISMRM 17th
Scientific Meeting & Exhibition, Honolulu, Hawai'i, USA 18-24 April 2009.

CURRICULUM VITAE of Ulrike Dydak, PhD 16
Panda A, James JR, Boettcher U, Raghavan RS, Sandrasegaran K, Aisen A, Stark H, Bansal N,
Dydak U. 31 P Spectroscopic Imaging with GRAPPA. ISMRM 17th Scientific Meeting &
Exhibition, Honolulu, Hawai'i, USA 18-24 April 2009.
James JR, Lin C, Dydak U, Babsky AM, Stark H, Dale BM, Bansal N, Sodium MR Imaging at
3T Using an 8-Channel 23 Na and 2-Channel 1 H Rx/Tx Coil: Optimization and RF
Inhomogeneity Corrections. ISMRM 17th Scientific Meeting & Exhibition, Honolulu, Hawai'i,
USA 18-24 April 2009.
Dydak U, Jiang Y, Long L, Chen J, Li WM, Murdoch J, Meier D, Aschner M, Zheng W,
Assessment of Manganese Exposure by 3D high-resolution T1-weighted MRI, SOT Annual
Meeting, Baltimore, MD, USA, March 15-19, 2009.
Panda A, Sandrasegaran K, Dydak U.
A Novel 31P Magnetic Resonance Spectroscopy Coil for Noninvasive Monitoring of the Respo
nse of Hepatocellular Carcinoma to Radiotherapy. AAPM Ohio River Valley Spring 2009
Educational Symposium, Cincinnati, OH, USA, March 7, 2009
2008
Dydak U, Raghavan RS, Murdoch J, Träber F, Posse S, Stoesz M, Björkmann-Burtscher I, Fast
Spectroscopic Imaging: Which technique to choose?, Radiological Society of North America
(RSNA), December 2008 (Magna Cum Laude award)
Sandrasegaran K, Dydak U, Akisik FM, Bansal N, Aisen AM. MR Spectroscopy of
Abdominopelvic Disease. Presented at Society of Gastrointestinal Radiology (SGR) annual
meeting, Rancho Mirage, CA, February 2008 (Second place award)
Walter M., Henning A., Grimm S., Schulte R.F., Beck J., Dydak U., Schnepf B., Boeker H.,
Boesiger P., Northoff G. Alterations in BOLD Response and Metabolite Concentrations
support Decreased Glial Enzyme Activity in Major Depression: A Quantitative JPRESS and
fMRI Study. ISMRM Sixteenth Scientific Meeting, Toronto, Canada, May 3 -9, 2008 (first
place of poster awards for psychiatric diseases)
Raghavan R.S., Dydak U. Fast Magnetic Resonance Spectroscopic Imaging Techniques: A
Comparative Analysis. Indiana Neuroimaging Symposium, Indianapolis, IN, USA, April 25,
2008.
Zhao Q., Ho C.Y., Kalnin, A., Dydak U. SpectroHUB: Example Database for Clinical MR
Spectroscopy. Indiana Neuroimaging Symposium, Indianapolis, IN, USA, April 25, 2008.
Panda A., Raghavan R.S., Dzemidzic M., O’Connor S.J., Kareken D.A., Dydak U. Detection of
Brain Ethanol Level using Magnetic Resonance Spectroscopy. Indiana Neuroimaging
Symposium, Indianapolis, IN, USA, April 25, 2008.
2007
Dydak U, Roberts TP, Tyszka JM, Rowley HA. Dynamic Whole Brain Spectroscopic Imaging
and fMRI of Ethanol Uptake in the Brain. Indiana Neuroimaging Symposium, Bloomington, IN,
USA, May 14, 2007

CURRICULUM VITAE of Ulrike Dydak, PhD 17
2006
Dydak U, Roberts TP, Tyszka JM, Boesiger P, Rowley HA. Dynamics of Ethanol Uptake in the
Brain by Whole Brain MRSI, ADC Mapping and BOLD fMRI. Joint Annual Meeting of the
German, Austrian and Swiss Society for Biomedical Engineering, Zürich, Switzerland,
September 6-9, 2006.
Thomas Lange, Andreas H. Trabesinger, Rolf F. Schulte, Ulrike Dydak, Peter Boesiger. Prostate
Spectroscopy at 3 Tesla Using Two Dimensional S-PRESS. Joint Annual Meeting of the
German, Austrian and Swiss Society for Biomedical Engineering, Zürich, Switzerland,
September 6-9, 2006.
Henning A, Schär M, Kollias S, Dydak U, Boesiger P. Spinal cord MRS in and beyond the
cervical spine. Joint Annual Meeting of the German, Austrian and Swiss Society for Biomedical
Engineering, Zürich, Switzerland, September 6-9, 2006.
Poryazova R, Schnepf B, Werth E, Meier D, Boesiger P, Dydak U, Bassetti CL; Dysfunction of
the right amygdala in narcolepsy? A proton spectroscopy study. 10th Congress of the EFNS
(European Federation of Neurological Societies), Glasgow Scotland, UK, September 2-5,
2006.
Schnepf B, Poryazova R, Meier D, Werth E, Dydak U, Bassetti CL, Boesiger P; Metabolic
Changes in the Right Amygdala. Human Bran Mapping, Florence, Italy, June 11-15, 2006.
Poryazova R, Schnepf B, Werth E, D. Meier, U. Dydak, Boesiger P, Bassetti CL; Narcolepsy
studied by magnetic resonance spectroscopy. 16th ENS (European Neurological Society)
Meeting: Lausanne, May 27-31, 2006.
Dydak U, Possanzini C, Kozerke S, Kruiskamp M, Meier D, Luechinger R, Boesiger P. 3D
SENSE Spectroscopic Imaging with Acceleration in Three Dimensions. ISMRM Fourteenth
Scientific Meeting, Seattle, Washington, USA, May 8 -12, 2006.
Possanzini C, Dydak U, Kozerke S, Kruiskamp M, Luechinger R, Warntjes M, van Uden M,
Ylihautala M, Boesiger P, Visser F. A novel 16-element coil for SENSE brain/neurovascular
imaging. ISMRM Fourteenth Scientific Meeting, Seattle, Washington, USA, May 8 -12, 2006.
Henning A, Schär M, Kollias S., Meier D, Boesiger P, Dydak U. Spinal Cord MRS in and beyond
the Cervical Spine. ISMRM Fourteenth Scientific Meeting, Seattle, Washington, USA, May 8 -
12, 2006.
Lange T, Trabesinger AH, Schulte RF, Dydak U, Boesiger P. Prostate Spectroscopy at 3 Tesla
Using Two-Dimensional S-PRESS. ISMRM Fourteenth Scientific Meeting, Seattle,
Washington, USA, May 8 -12, 2006.
Dydak U, Possanzini C, Kozerke S, Kruiskamp M, Luechinger R, Boesiger P. 3D SENSE
Spectroscopic Imaging with Reduction Factors in 3 Dimensions. ASNR 44 th
Annual Meeting, San Diego, CA, USA, April 29-May 5, 2006.
Henning A, Schär M, Schulte RF, Kollias S, Boesiger P, Dydak U. Spinal Cord MRS beyond the
Cervical Spine. ASNR 44 th Annual Meeting, San Diego, CA, USA, April 29-May 5, 2006.

CURRICULUM VITAE of Ulrike Dydak, PhD 18
2005
Henning A, Schär M, Schulte RF, Pruessmann KP, Dydak U, Boesiger P. Outer Volume
Suppression in MRSI using equi-ripple designed quadratic phase RF pulses. 22 nd Annual
Meeting of ESMRMB, Basel, Switzerland, September 15-18, 2005. (received the outstanding
poster award)
Henning A, Dydak U, Schär M, Schulte RF, Pruessmann KP, Boesiger P. Improved Outer
Volume Suppression in Magnetic Resonance Spectroscopy. Annual Meeting of the Swiss
Society for Biomedical Engineering, Lausanne, Switzerland, September 1-2, 2005.
Henning A, Dydak U, Bjeljac M, Kollias SS, Hamprecht F, Boesiger P. Accelerated highresolution
spectroscopic imaging in Brain tumour diagnostics. Annual Meeting of the Swiss
Society for Biomedical Engineering, Lausanne, Switzerland, September 1-2, 2005.
Dydak U, Lange T, Alexander AL, Roberts TPL, Rowley H, Boesiger P. Pitfalls in Lactate
Measurements with MRS at High Field Strength. ASNR 43 rd Annual Meeting, Toronto,
Canada, May 21-27, 2005 (received the ASFNR outstanding presentation award).
Dydak U, Kollias SS, Boesiger P. MR Spectroscopy of the Healthy and Tumorous Cervical Spinal
Cord. ASNR 43 rd Annual Meeting, Toronto, Canada, May 21-27, 2005
Dydak U, Kollias SS, Schaer M, Meier D, Boesiger P. MR Spectroscopy in Different Regions of
the Spinal Cord and in Spinal Cord Tumors. ISMRM Thirteenth Scientific Meeting, Miami,
Florida, USA, May 7-13, 2005.
Dydak U, Mueller S, Meier D, Sandor PS, Boesiger P, Jung HH. Cerebral Metabolic Alterations
in McLeod Syndrome. ISMRM Thirteenth Scientific Meeting, Miami, Florida, USA, May 7-13,
2005.
Henning A, Dydak U, Boesiger P. Advanced Processing of MR Spectra Recorded Using
"Maximum Echo Acquisition". ISMRM Thirteenth Scientific Meeting, Miami, Florida, USA,
May 7-13, 2005.
Henning A, Schär M, Schulte R, Meier D, Dydak U, Boesiger P. Outer Volume Suppression in
MRSI Using Equi-Ripple Designed Quadratic-Phase RF Pulses. ISMRM Thirteenth Scientific
Meeting, Miami, Florida, USA, May 7-13, 2005.
2004
Henning A, Jauslin M, Lange T, Nadig K, Sandor PS, Boesiger P, Dydak U. fMRI and fMRSI at
3T to Study Habituation in the Primary Visual Cortex of Migraine Patients: Optimization of the
Methods. Annual Symposium of the Neuroscience Center Zurich, Zurich, Switzerland, October
15, 2004.
Jauslin M, Lange T, Henning A, Sandor PS, Dydak U, Boesiger P. Functional Spectroscopic
Imaging at 3T to Assess Lactate Changes during Visual Stimulation in Migraine. Third
International Symposium on HighField MR in Clinical Applications, Bonn, Germany,
September 17-18, 2004.

CURRICULUM VITAE of Ulrike Dydak, PhD 19
Lange T, Dydak U, Sandor P, Boesiger P. Functional Spectroscopic Imaging at 3 Tesla to Assess
Lactate Changes in Healthy Brain During Visual Stimulation. First EENC/AMPERE Joint
Meeting, Lille, France, September 6-11, 2004.
Dydak U, Roberts TPL, Tyszka JM, Boesiger P, Rowley HA. Dynamic Whole Brain
Spectroscopic Imaging and fMRI of Ethanol Uptake in the Brain. 42 nd Annual Meeting of the
American Society of Neuroradiology, Seattle, USA, June 5-11, 2004.
Rowley HA, Dydak U, Tyszka JM, Roberts TPL. Apparent Diffusion Coefficient Changes in
Cerebellum and Deep White Matter with Acute Alcohol Ingestion. 42 nd Annual Meeting of the
American Society of Neuroradiology, Seattle, USA, June 5-11, 2004.
Dydak U, Roberts TPL, Tyszka JM, Boesiger P, Rowley HA. The Dynamics of Ethanol Uptake in
the Brain by Whole Brain MRSI, ADC Mapping and BOLD fMRI. Twelfth Scientific Meeting
and Exhibition ISMRM, Kyoto, Japan, May 15-21, 2004.
Dydak U, Tyszka JM, Cadioli M, Rowley HA, Roberts TPL, Boesiger P. Dynamic Whole Brain
Spectroscopic Imaging using Multiple Spine Echoes at 3T. Twelfth Scientific Meeting and
Exhibition ISMRM, Kyoto, Japan, May 15-21, 2004.
Lange T, Dydak U, Sandor P, Boesiger P. Lactate Detection in Healthy Brain During Visual
Stimulation Using fMRSI. Twelfth Scientific Meeting and Exhibition ISMRM, Kyoto, Japan,
May 15-21, 2004.
2003
Dydak U., Meier D., Kozerke S., Boesiger P. Ein Blick in den Gehirnstoffwechsel: Schnelle 3D
MR Spektroskopische Bildgebung. Dreiländertreffen Biomedizinische Technik, Salzburg, AT,
September 24-27, 2003.
Dydak U., Meier D., Lamerichs R., Boesiger P. High resolution MRSI in less than a minute, 20 th
Annual Meeting of ESMRMB, Rotterdam, The Netherlands, September 18-21, 2003.
Lange T., Dydak U., Schulte R.F.,. Trabesinger A.H., Boesiger P. Recovering the lactate signal at
3T, 20 th Annual Meeting of ESMRMB, Rotterdam, The Netherlands, September 18-21, 2003.
Dydak U., Meier D., Lamerichs R., Boesiger P. Using the high spectral resolution at 3T for
speeding up MRSI. Highfield Symposium, Bonn, Germany, September 5-7, 2003.
Trabesinger A.H., Meier D., Dydak U., Lamerichs R., Boesiger P. Optimizing Citrate Detection at
3 Tesla, Eleventh Scientific Meeting and Exhibition ISMRM, Toronto, Canada, July 10-16,
2003.
Sánchez J., Tsao J., Dydak U., Desco M., Boesiger P., Pruessmann K.P. Minimum Norm
Reconstruction for Parallel Spectroscopic Imaging, Eleventh Scientific Meeting and Exhibition
ISMRM, Toronto, Canada, July 10-16, 2003.
Dydak U., Schmidt C., Koch S., Sandor P.S., Boesiger P. Comparison of different visual stimuli at
two field strengths with fMRI. Human Brain Mapping Conference 2003, New York, USA, June
18-22, 2003.
2002

CURRICULUM VITAE of Ulrike Dydak, PhD 20
Dydak U, Kozerke S, Meier D, Pruessmann KP, Boesiger P. Parallel MR Spectroscopic Imaging:
Fast Whole Brain Coverage using 3D Techniques, 2 nd European Medical and Biological
Engineering Conference, Vienna, Austria, Dec. 2002.
Dydak U, Tsao J, Kozerke S, Pruessmann KP, Meier D, Kollias SS, Bjeljac M, Boesiger P.
SENSE Spectroscopic Imaging at 3T, International Symposium on Highfield MR in Clinical
Applications, Bonn, Germany, Oct. 2002.
Dydak U, Pruessmann KP, Kozerke S, Tsao J, Meier D, Boesiger P. Parallel 3D Spectroscopic
Imaging, Proceedings ESMRMB 19 th Meeting, Cannes, MAGMA 15, p.110 (# 231), 2002.
Dydak U, Sandor PS, Crelier G, Kollias SS, Agosti R, Boesiger P. Habituation-like Behavior to
Visual Stimulation is reduced in Migraine. Proceedings 8 th International Conference on
Functional Mapping of the Human Brain, Sendai, 2002.
Dydak U, Sandor PS, Schoenen J, Crelier GR, Kollias SS, Hess K, Agosti RM, Boesiger P, Minor
metabolic Abnormalities studied with Functional Spectroscopic Imaging in Patients with
Migraine, Proceedings 8 th International Conference on Functional Mapping of the Human
Brain, Sendai, 2002.
Dydak U, Kozerke S, Van Ensbergen G, Meier D, Pruessmann KP, Boesiger P, SENSE
Spectroscopic Imaging: 3D versus 2D Multi-Slice, Proceedings ISMRM 10 th Meeting,
Honolulu, 2002
Dydak U, Sandor PS, Crelier G, Kollias SS, Agosti R, Boesiger P, Reduced Habituation to Visual
Stimulation in Migraine, Proceedings ISMRM 10 th Meeting, Honolulu, 2002.
2001
Dydak U, Sandor PS, Schoenen J, Crelier G, Kollias SS, Hess K, Agosti RM, Boesiger P,
Functional Spectroscopic Imaging in Patients with Migraine, Proceedings ISMRM 9 th Meeting
and ESMRMB 18 th Meeting, Glasgow, p. 383, 2001.
Dydak U, Pruessmann KP, Weiger M, Meier D, Boesiger P, Fast Multislice Spectroscopic
Imaging using SENSE, Proceedings ISMRM 9 th Meeting and ESMRMB 18 th Meeting, Glasgow,
p. 625, 2001.
Schmidt C, Crelier G, Dydak U, Boesiger P, Event-related Perfusion Measurement using TILT
and Balloon-Model Description of the Hemodynamic Response to Short Stimuli, Proceedings
ISMRM 9 th Meeting and ESMRMB 18 th Meeting, Glasgow ,p. 1163, 2001.
2000
Dydak U, Weiger M, Pruessmann KP, Meier D, Boesiger P, Sensitivity Encoded Multi-Echo
Spectroscopic Imaging, Proceedings ISMRM 8 th Meeting, Denver, p. 368, 2000.
Dydak U, Pruessmann KP, Weiger M, Boesiger P, The Spatial Response Function in SENSE-SI,
Proceedings ISMRM 8 th Meeting, Denver, 1848, 2000.
Dydak U, Pruessmann KP, Weiger M, Boesiger P, The spatial response function in sensitivity
encoded spectroscopic imaging, Proceedings ESMRMB 17 th Meeting, Paris, MAGMA 11, p.175
(# 406), 2000.

CURRICULUM VITAE of Ulrike Dydak, PhD 21
Dydak U, Sandor PS, Schoenen J, Crelier G, Kollias S, Agosti RM, Boesiger P, Lactate changes
during visual stimulation in migraine with aura, Proceedings ESMRMB 17 th Meeting, Paris,
MAGMA 11, p. 222 (# 497), 2000.
Schmidt CF, Crelier GR, Dydak U, Boesiger P, Event-related perfusion measurement using TILT,
Proceedings ESMRMB 17 th Meeting, Paris, MAGMA 11, p. 108 (# 274), 2000.
Dydak U, Pruessmann KP, Weiger M, Meier D, Boesiger P, ‘Sensitivity Encoding’ für schnelle
spektroskopische Bildgebung, 3 rd Annual meeting of the German Chapter of the ISMRM, 2000
1999
Dydak U, Weiger M, Pruessmann KP, Van den Brink J, Lamerichs R, Meier D, Boesiger P, Scan
Time Reduction in Spectroscopic Imaging, Proceedings ISMRM 7 th Meeting, Philadelphia, p.
679, 1999.
Dydak U, Weiger M, Pruessmann KP, Meier D, Boesiger P, Faster Turbo Spectroscopic Imaging
Using SENSE, Proceedings ESMRMB 16 th Meeting, Seville, MAGMA 8, p. 18 (# 55), 1999.
Dydak U, Weiger M, Pruessmann KP, Meier D, Boesiger P, Scan Time Reduction in
Spectroscopic Imaging, Proceedings EMBEC ’99, Vienna, p. 988, 1999.
Ongoing Research Support
Dydak (PI)
NIH/NIEHS ONES R01 ES020529 09/12/2011 – 04/30/2016
Neuroimaging for Early Diagnosis of Manganese Toxicity in Humans and Rodents
This grant aims to develop and use novel MRI and MRS techniques to find biomarkers of effect
and explore the underlying mechanism of Manganese neurotoxicity in the human and the rodent
brain.
Role: PI
Dydak (PI)
Purdue University Center for Cancer Research Challenge Grant 04/01/2012-03/31/2013
3D 31P MRSI of Human Liver: A Spatially-resolved Study of Normal and Malignant Tissue
Response to Radiation Therapy
Role: PI
Neu (PI)
NIH/NIAMS R21 MH098931 09/01/2012 – 08/31/2014
Combined Biophysical and Biochemical Study of Single Cells
The objective of this application is to develop a hybrid magnetic resonance-based nanotechnology
that enables simultaneous imaging and spectroscopy of single cells.
Role: Co-I
Campbell W (PI)
National Dairy Council 09/01/2011 - 09/30/2013
Effects of milk protein concentrate on blood pressure, inflammation, muscle composition, and
metabolic health in overweight/obese adults

CURRICULUM VITAE of Ulrike Dydak, PhD 22
To assess the effects of an energy restriction, higher protein diet achieved using milk protein
concentrate beverage supplements on blood pressure, inflammation, muscle composition, and
metabolic health in overweight/obese adults before, at mid-point and after a 16-wk dietary
intervention.
Role: Co-I
Dydak (PI)
Purdue Research Foundation Research Award 06/01/2013 – 05/31/2014
GABA MR spectroscopy as a potential biomarker for Parkinson disease
This project will use magnetic resonance spectroscopy to study the hypothesis that increased basal
ganglia GABA levels might serve as early biomarker in Parkinson’s Disease.
Role: PI
Talavage (PI)
Indiana CTSI, Spinal Cord and Brain Injury Research Fund (SCBI 207-32)
08/01/2012 – 07/31/2014
MR Spectroscopic Quantification of Brain Injury in High School Athletes,
Role: Co-PI
Completed Research Support
Dydak (PI) 06/01/2012 – 05/31/2013
Purdue Research Foundation Research Award
MR spectroscopy for understanding brain gamma-aminobutyric acid (GABA) alteration and its
association with dopamine (DA) neuronal degeneration in manganese (Mn)-induced
Parkinsonism
Role: PI
Dydak (PI) 09/05/2009 – 06/30/2011
NIH/NIEHS R21 ES017498
Effect of Manganese Exposure on GABA and Glutamate in Human Brains by MRS
This project will apply novel MRI/MRS techniques to explore the changes in brain metabolism
caused by Mn exposure among smelting workers and patients with Mn-induced Parkinsonism.
Role: PI
Dydak (PI) 01/01/2011 – 12/31/2012
CTSI Core Pilot Funding
In-Vivo GABA MRS of Metal Toxicity in the Human Brain
To install and test the GABA-editing technique MEGA-PRESS at the Purdue MRI scanner and
acquire pilot data in five Mn-exposed welders.
Role: PI
Dydak (PI) 01/01/2010 – 12/31/2012
CTSI Core Pilot Funding
Development of Fast GABA Mapping in the Human Brain
To develop and test the technique of MEGA-PEPSI for GABA spectroscopic imaging in
phantoms and in vivo.

CURRICULUM VITAE of Ulrike Dydak, PhD 23
Role: PI
Janle E (PI) 05/01/2012 – 04/30/2013
Mead Johnson
Assessment of the bioavailability and functionality of brain-targeting polyphenol metabolites in
piglets
Role:Co-I
Campbell W (PI)
American Egg Board –Egg Nutrition Center 01/01/2011 – 12/31/2012
Effect of increased egg-based protein intake on muscle composition, metabolic health and
systemic inflammation in obese older adults.
Role: Co-I
Goddard and Dydak (PIs) 03/01/2009 – 02/28/2011
Indiana CBR/CTR Pilot Grant
GABA Neuronal Dysfunction in Panic Disorder: Assessing the Effect of Family History
The major goals of the project are to demonstrate that the magnitude of the cortical GABA deficit
in patients with panic disorder is related to the presence or absence of a family history of panic
disorder by MRS.
Role: Co-PI
Anand/Dydak (PI) 08/01/2009 – 06/30/2013
Indiana CBR/CTR Pilot Grant (CTSI)
Neurochemistry of Mood Regulating Circuit in Bipolar Disorder: An Ultrafast Whole Brain
Magnetic Resonance Spectroscopy (MRS) Study
The major goal of this pilot project is to use the whole brain PEPSI-MRSI sequence to assess
brain metabolism and its changes in untreated patients with bipolar disorder.
Role: Co-PI
Dydak/Sandrasegaran (PI) 07/01/2009 – 06/30/2011
Indiana CBR/CTR Pilot Grant (CTSI)
31P magnetic resonance spectroscopy in liver cancer: Evaluation of response to yttrium-90 radioembolization
therapy
The major goal of this pilot project is to test feasibility and reproducibility of acquiring 31P MRSI
data from liver cancer tumors treated with yttrium-90 radio-embolization.
Role: PI
Sandrasegaran (PI) 09/01/2008 - 08/31/2010
Showalter Trust Award – Indiana Univeristy
Determination of Response Of Hepatocellular Cancer to Stereotactic Body Radiation Therapy:
Value of Diffusion-Weighted Magnetic Resonance Imaging and Phosphorus-31 MR Spectroscopy
Diffusion-Weighted MRI and Phosphorus-31 MR Spectroscopy are applied to monitor the
response of hepatocellular cancer to stereotactic Body Radiation Therapy.
Role: Co-investigator

CURRICULUM VITAE of Ulrike Dydak, PhD 24
Dydak (PI) 07/01/2009 – 06/30/2010
Showalter Trust Award – Purdue University
New Therapeutic Treatment of Manganese Parkinsonism by Para-amino Salicylic Acid: Magnetic
Resonance Imaging and Spectroscopy Study
The major goals of the project are to explore the effects of Para-amino salicylic acid as a
therapeutic agent for manganism by means of MRS in the rat.
Dydak (PI) 12/01/2007 – 09/30/2010
IUSM – Siemens Pilot Funding Program
Implementation and Evaluation of fast MRSI techniques for brain and body MRSI at 3T
Implementation and optimization of parallel spectroscopic imaging methods (SENSE and
GRAPPA), as well as an EPI-based and a multiple-spin-echo based technique on a Siemens 3T
MRI scanner. Evaluation of the optimal techniques for applications in human brain and breast.
Role: PI
Sandrasegaran (PI) 03/01/09 – 02/28/10
Society of Gastrointestinal Radiologists
Early Prediction of the Response of Hepatocellular Cancer to Yttrium-90 Radio-embolization
using MRI and MR Spectroscopy
This study will investigate the value of diffusion-weighted MRI and 1H-MRS to monitor the
response of hepaticellular cancer to Yttrium-90 Radio-embolization therapy.
Role: Co-investigator
Zheng (PI) 04/01/08 - 03/31/09
U.S. DoD USAMRMC W81XWH-05-1-0239
MRI and MRS in Manganese-Exposed Smelting Workers: Relationship to
External and Internal Exposure Indices
This study will use magnetic resonance imaging and spectroscopic techniques to mechanistically
explore Mn-elicited neuronal damage among a well-established smelter cohort in Zunyi, China.
Role: Co-investigator
34250603 Sandor (PI) 09/24/2003 – 12/31/2006
Merck Medical School Grant,
Neuronal activity and metabolism in the common forms of migraine, including central effects of
rizatriptan, studied with functional magnetic resonance techniques.
This study investigated changes in metabolism during extended periods of visual stimulation in
common forms of migraine, including the effects of the medication rizatriptan, by means of
dynamic MR spectroscopic imaging.
Role: Co-Investigator
SEP TH-7/02-2 Boesiger (PI) 06/2002 – 06/2005
Strategic Excellence Projects, ETH Zurich

CURRICULUM VITAE of Ulrike Dydak, PhD 25
User lab MRI: New Magnetic Resonance Imaging Techniques for the Assessment of Brain and
Heart Function
Methodological developments of high field (3T) MRI and MRS techniques for the assessment of
brain and heart function
Role: Co-Investigator
54250601 Sandor (PI) 10/01/2002 – 12/31/2004
Research Grant of the University Zurich
Neuronal activity and metabolism in the common forms of migraine and the effect of prophylaxis
studied with functional magnetic resonance techniques.
This study investigated possible changes in metabolism during extended periods of visual
stimulation in patients with common forms of migraine and control subjects by means of dynamic
MR spectroscopic imaging.
Role: Co-Investigator