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‘ When Hodgkin and I finished writing the 1952 papers, each of us moved to other lines of work because we could not see how to make progress on the mechanism of channel action. Any idea of analyzing the channels by patch clamp or molecular biology would have seemed to us to be… science fiction ‘. Andrew Huxley, in The Axon, 1995
Na V 1.5 channels, localized on the endosomal membrane, provide a route for Na efflux that offsets proton influx during acidification of phagocytosed material Activation of Na V 1.5 with Veratridine triggers Na efflux and proton influx (acidification) of purified THP-1 endosomes Carrithers et al J. Immunol., 2007
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