Part 4
Part 4
Part 4
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Na V 1.6 Co-localizes with cytoskeletal F-actin, vimentin in TMP- human<br />
monocytic cell line, and in primary human macrophages<br />
shRNA knockdown of Na V 1.6, and Na channel block with TTX and<br />
phenytoin inhibit macrophage and microglial migration<br />
NaV1.6<br />
F-actin (phalloidin)<br />
Merge+DAPI<br />
Carrithers et al, J. Immunol. 2007<br />
Carrithers et al, JBC, 2008<br />
Microglia/6.3x10 5 m 2<br />
90<br />
80<br />
70<br />
60<br />
50<br />
40<br />
30<br />
20<br />
10<br />
0<br />
*<br />
#<br />
ACM ACM +<br />
ATP<br />
ACM +<br />
ATP +<br />
ACM +<br />
ATP +<br />
0.3 M TTX 10 M TTX<br />
#<br />
Black et al, Glia, 2009
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