Schweizer Archiv für Neurologie und Psychiatrie ... - Sanp.ch
Schweizer Archiv für Neurologie und Psychiatrie ... - Sanp.ch
Schweizer Archiv für Neurologie und Psychiatrie ... - Sanp.ch
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Posters SSCN<br />
16<br />
Validation of Copeptin as prognostic marker in is<strong>ch</strong>emic<br />
stroke<br />
G. M. De Mar<strong>ch</strong>is 1 , M. Katan 2 , A. Weck 1 , H. P. Mattle 1 ,<br />
C. Breckenfeld 1 , Ph. S<strong>ch</strong>ütz 2 , Ch. Foer<strong>ch</strong> 3 , M. Seiler 4 ,<br />
F. Hein 4 , J. Papassotiriou 4 , M. Christ-Crain 2 , M. Arnold 1<br />
1<br />
Inselspital, Bern, Switzerland, 2 University Hospital, Basel,<br />
Switzerland, 3 Goethe University, Frankfurt, Germany,<br />
4<br />
B. R. A. H. M. S., Hennigsdorf-Berlin, Germany<br />
Objectives: The rapid and reliable estimation of prognosis in<br />
is<strong>ch</strong>emic stroke is pivotal to optimize clinical care. In a recent<br />
study we demonstrated that Copeptin is a new accurate<br />
prognostic marker in is<strong>ch</strong>emic stroke. This ongoing study aimed<br />
to validate Copeptin as prognostic marker in is<strong>ch</strong>emic stroke.<br />
Methods: Data of the first 198 patients with is<strong>ch</strong>emic stroke who<br />
were consecutively admitted to the emergency department of<br />
the Inselspital Bern were analysed. On admission, severity of<br />
is<strong>ch</strong>emic stroke was assessed by the National Institute of Health<br />
Stroke Scale (NIHSS). In all patients, Copeptin levels were<br />
measured within 24 hours of symptom onset and compared with<br />
outcome after 3 months as assessed with the modified Ranking<br />
scale (mRS).<br />
Results: Of the 198 patients with is<strong>ch</strong>emic stroke, 34% patients<br />
were female and the median age was 67 years. The median<br />
NIHSS was 5 (interquartile range [IQR] 2-14), and 61 patients<br />
(30.1%) had an unfavorable outcome (mRS >2). Copeptin<br />
levels on admission were higher in patients with an unfavorable<br />
outcome compared to those with a favorable outcome (31.9<br />
pmol/l , IQR 15.2–76.6 versus 9.25 pmol/l, IQR 4.8–27.2, p<br />