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The Role of Autologous Bone Marrow Transplantation in the Treatment of Childhood Lymphoblastic Leukemia: Experience of the Italian Pediatric Study Group 151 Paolo Colleselli, Guido Sotti, Marino Andolina, Fulvio Porta, Giorgio Dini, Chiara Messina, Maria Vittoria Gazzola, Eriberto Agosti, Andrea de Manzini, Luigi Nespoli, and Sandro Dallorso Autologous Marrow Transplant Experience for Acute Lymphoblastic Leukemia 155 Jean E. Sanders, Kristine C. Doney, Roger Hill, Paul Martin, C. Dean Buckner, Frederick R. Appelbaum, William I. Bensinger, Finn Bo Petersen, Ronald Berenson, Keith M. Sullivan, Rainer Storb, and E. Donnall Thomas Autologous Bone Marrow Transplantation Using Monoclonal Antibody Purged Marrow in Acute Lymphoblastic Leukemia 161 Bengt Simonsson, Gudmar Lonnerholm, Bengt Smedmyr, Thomas Totterman, and Gunnar Oberg Autologous Bone Marrow Transplantation for Childhood and Adult Acute Lymphoblastic Leukemia in First or Second Complete Remission: 1988 Update 167 J. Y. Cahn, E. Plouvier, M. Flesch, and P. Herve B43/CD19-PAP Is an Effective Immunotoxin and Shows Considerable Clinical Potential for Both Ex Vivo and In Vivo Immunotherapy of B-Lineage ALL 171 Fatih M. Uckun, James D. Irvin, Woo S. Min, John H. Kersey, and Dorothea E. Myers Detection of Minimal Residual Disease in Acute Myelogenous Leukemia by RNA-In Situ Hybridization 179 Mary Jean Evinger-Hodges, Jorge A. Spinolo, Irene Cox, Verneeda Spencer, Pedro Nieto, and Karel A. Dicke DISCUSSIONS 1-3 187 Session II - Lymphoma Autologous Bone Marrow Transplants Purged with Monoclonal Antibodies and Complement in B-Cell Lymphomas: A Review of 47 Cases 199 Marie Favrot, Irene Philip, Frank Chauvin, Valerie Combaret, Gilles Clapisson, Fathia Mezziane, Pierre Biron, George Janossy, and Thierry Philip Vlii
High-Dose Therapy and Autologous Bone Marrow Transplantation in Partial Remission After Front Line Induction Therapy in Lymphoma: The Best Indication for ABMT in 1988? 207 O. Hartmann, F. Chauvin, P. Biron, E. Pavone, J. Y. Cahn, F. Pein, P. Bordigoni, G. Souillet, M. Gartner, C. Lasset, and T. Philip Optimal Timing for ABMT in Intermediate- and High-Grade Non- Hodgkin's Lymphomas 217 Enzo Pavone, Frank Chauvin, Pierre Biron, and Thierry Philip Autologous Bone Marrow Transplantation (ABMT) in Non- Hodgkin's Lymphoma (NHL) and Hodgkin's Disease (HD): The Role of Tumor Cell Resistance versus Tumor Bulk in the Timing of Therapy 225 Herbert Kaizer, Richard Ghalie, Sharon Manson, and Carol Richman Autologous BMT for Patients with Poor-Prognosis Lymphoma and Hodgkin's Disease 231 S. Gulati, B. Shank, J. Yahalom, G. Toner, J. Crown, A. Sarris, C. Little, J. Myers, P. Black, J. Yopp, D. Straus, R. Warrell, L. Lesko, N. Kernan, D. Filippa, M. Doherty, I. Cunningham, E. Berman, M. Colvin, M. Coleman, J. Bertino, Z. Fuks, R. O'Reilly, and B. Clarkson DISCUSSION 1 241 Bone Marrow Transplantation for Adult Poor Prognosis Lymphoblastic Lymphoma 247 Noel Milpied, Norbert Ifrah, Mathieu Kuentz, Dominique Maraninchi, Philippe Colombat, and Jean-Luc Harousseau High Dose Therapy for Multiple Myeloma 253 Bart Barlogie, Karel A. Dicke, and Raymond Alexanian Optimal Timing of Autologous Bone Marrow Transplantation for Patients with Hodgkin's Lymphoma 261 Angelo M. Carella, Angela M. Congiu, Patrizio Mazza, Giovanni Meloni, Lina Mangoni, Alessandro Levis, Adolfo Porcellini, Emilio P. Alessandrino, Renato Bassan, Paolo Coser, Franco Benedetti, Sante Tura, Franco Mandelli, Vittorio Rizzoli, Luigi Resegotti, Carlo Bernasconi, Tiziano Barbui, and Alberto M. Marmont ix
Page 1: Autologous Bone Marrow transplantat
Page 5 and 6: AUTOLOGOUS BONE MARROW TRANSPLANTAT
Page 7 and 8: Contents Preface xxi Acknowledgment
Page 9: High Dose Etoposide, Melphalan, Tot
Page 13 and 14: Autologous Bone Marrow Transplantat
Page 15 and 16: Breast Tumor Cell Detection in Marr
Page 17 and 18: High Dose Chemo-Radiotherapy with B
Page 19 and 20: The Use of Recombinant Human Granul
Page 21: Session VIII - Further Developments
Page 25: Acknowledgments Publication of thes
Page 29 and 30: CBV and ABMT for AML in CRI 3 DOES
Page 31 and 32: CBV and ABUT for AML in CR1 5 Bone
Page 33 and 34: CBV and ABMT for AML in CR1 7 27 36
Page 35 and 36: CBV and ABMT for AML in CR1 Table 3
Page 37 and 38: CBV and ABMT for AML in CRI 11 ACKN
Page 39 and 40: Mafosfamide Purging in Acute Leukem
Page 47 and 48: Timing of BMT for ANL 21 TIMING OF
Page 49 and 50: Timing of BMT for ANL 23 Unlike che
Page 51 and 52: Timing of BMT for ANL 25 autologous
Page 53 and 54: Timing of Bone Marrow Transplantati
Page 55 and 56: Merocyanine-540 and Mafosfamide Pur
Page 57 and 58: Merocyanine-540 and Mafosfamide Pur
Page 59: Merocyaniñe-540 and Mafosfamide Pu
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Sensitivity of Leukemic Progenitors
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38 Sensitivity of Leukemic Progenit
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ABMT for Consolidation of AML/ALL i
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56 Hematopoietic Progenitor Selecti
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62 Acute Leukemia - AML (Purging) (
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64 Acute Leukemia - AML (Purging) T
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4HC/VCR Chemopurge 67 CHEMOPURGE WI
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4HC/VCR Chemopurge 69 Table 1. Pati
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4HC/VCR Chemopurge 71 remain in rem
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Autologous BMT for ANLL 73 AUTOLOGO
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Autologous BMT for ANLL 75 Hematolo
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Autologous BMT for ANLL 77 in CR2 o
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Clinical Value of Auto BMT 79 Discu
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BAVC and ABMT in AML Patients 81 BA
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BAVC and ABMT in AML Patients 83 Bo
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BAVC and ABMT in AML Patients 85 Ta
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ABMT in Advanced ALL 87 RESULTS OF
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ABMT in Advanced ALL 89 After hemat
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ABMT in Advanced ALL 91 Two differe
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94 Autograft for AML Since no concl
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96 Autograft for AML 8 16 24 32 40
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98 Autograft for AML relapse free p
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Etoposide, Melphalan, TBI and ABMT
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Page 131:
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108 J In Vitro/In Vivo Treatment of
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110 In Vitro/In Vivo Treatment of L
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112 In Vitro/In Vivo Treatment of L
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114 BU/CY in BMT CY alone is not an
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116 BU/CY in BMT BU CY PREPARATIVE
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118 BU/CY in BMT autologous or allo
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120 Double AML Transplants consolid
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122 Double AML Transplants 100 Even
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124 Double AML Transplants There is
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126 Double Transplants and 21 had a
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128 Double Transplants (ALL) and fu
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130 Double Transplants PROSPECTIVE
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132 Double Transplants months (22-7
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Autologous vs. Allogeneic Transplan
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SESSION I - LEUKEMIA B. ACUTE LEUKE
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140 ABMT vs. Chemotherapy in High R
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146 Marrow Transplantation for ALL
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148 Marrow Transplantation for ALL
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ABMT Italian Study for Childhood AL
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ABMT Italian Study for Childhood AL
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Autologous Transplant for ALL 155 A
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Autologous Transplant for ALL 157 R
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Autologous Transplant for ALL 159 n
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ABMT in ALL 161 AUTOLOGOUS BONE MAR
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ABMT in ALL 163 10< 5
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ABMT in ALL 165 NATIONAL SWEDISH AL
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ABMT in ALL 167 AUTOLOGOUS BONE MAR
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ABMT in ALL 169 98 X tlx 7IX (IX SI
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172 B43/CD19 PAP IT Table 1. Expres
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174 B43/CD19 PAP IT dialyzed, and f
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Figure 2. Biochemical Analysis of B
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178 B43/CD19 PAP IT 15. Uckun FM, K
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180 Detection of Minimal Residual D
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188 Autologous BMT vs. Chemotherapy
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190 Autologous BMT vs. Chemotherapy
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192 Autologous vs. Allogeneic Trans
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194 Timing & Conditioning Regimens
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196 Timing & Conditioning Regimens
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Purging with Anti-B Cell MoAb and C
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NO o 1—* c\i (M (M *— irt o •
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Front Line Chemotherapy Regimens 20
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•o tí id O IN GO ai o- CD «-
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CA CA 3 CU 4-» CD > t_ *-> CD C/l
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218 Optimal Timing for ABMT in Non-
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ABMT in NHL and HD — Timing of Th
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ABMT in NHL and HD - - Timing of Th
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ABUT in NHL and HD — Timing of Th
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The Role of Intensive Chemotherapy
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(H S m ¡3 < Xi •P •ri Se X tri
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242 Optimal Timing for Intermediate
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244 Optimal Timing for Intermediate
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BMT for Lymphoblastic Lymphoma 247
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High Dose Therapy for Multiple Myel
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Hodgkin's Disease, ABMT 261 OPTIMAL
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Hodgkin's Disease, ABMT 263 Table 1
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Hodgkin's Disease, ABMT 265 Table 3
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Hodgkin's Disease, ABMT 267 REFEREN
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270 Timing of ABMT in Hodgkin's Dis
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272 Timing of ABMT in Hodgkin's Dis
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Timing of CBV and Autologous BMT 27
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286 High Dose Chemotherapy Regimens
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Optimal Timing for Lymphoblastic Ly
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Optimal Timing for Lymphoblastic Ly
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298 Optimal Timing for Hodgkin's TB
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300 BMT Preparative Regimens marrow
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302 BMT Preparative Regimens As can
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Conditioning for AuBMT in NHL 305 A
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Conditioning for AuBMT in NHL 307 T
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Conditioning for AuBMT in NHL 309 e
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Escalating Dose CBV in Lymphoma 311
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318 High Dose Chemotherapy with ABM
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3 CD + i— ro
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ABMT in Low Grade NHL 327 AUTOLOGOU
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ABMT in Low Grade NHL 329 ABMT Foll
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Purging and Relapse in BL 331 EX-VI
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CD "O + >- CO CU c/l TJ a. CO CI C
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CO u- 3 < H CD < £ £¡ cf 25 3 <
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Purging and Relapse in BL 337 BM af
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Detection of MRD by PCR 339 DETECTI
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Detection of MRD by PCR 341 Figure
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Detection of MRD by PCR 343 results
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346 Conditioning Regimens in Lympho
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348 Conditioning Regimens in Lympho
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Studies in Indolent Lymphoma 351 Di
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354 Detection of Disease & Purging
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ABMT as Intensification in Breast C
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ABMT as Intensification in Breast C
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AB MT as Intensification in Breast
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364 Breast Cancer: Autologous Bone
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366 Breast Cancer: Autologous Bone
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368 High Dose Chemotherapy in Breas
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370 High Dose Chemotherapy in Breas
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372 High Dose Consolidation in Brea
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Page 404 and 405:
378 STAMP Studies in Breast Cancer
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CO •p fi 0) •rl •P id tU o o
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STAMP Studies in Breast Cancer 383
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386 Solid Tumors I: Breast clearly
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388 Solid Tumors I: Breast cannot i
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390 Dose Intensification for the Tr
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High-Dose Intensification for Breas
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406 ABMT and Hematopoietic Recovery
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Bone Marrow Metastases in Small Cel
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422 Occult Tumor in Bone Marrow RES
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424 Occult Tumor in Bone Marrow Tab
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Breast Tumor Cell Detection 427 BRE
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Breast Tumor Cell Detection 429 Nex
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Breast Cancer 431 Discussion 2 - Se
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Breast Cancer 433 Dr. Peters: We we
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Various Treatments in Gliomas 437 H
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Various Treatments in Gliomas 439 T
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Various Treatments in Gliomas 441 T
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Various Treatments in Gliomas 443 (
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Various Treatments in Gliomas 445 G
Page 473:
Various Treatments in Gliomas 447 d
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m í. o O ._• E CU c I co CJ M X
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452 ABMT in Pediatric Brain Tumors
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454 ABMT in Pediatric Brain Tumors
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Adjuvant High-Dose BCNU and BMT for
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Page 487:
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464 Gliomas Dr. Biron: It is so dif
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466 Gliomas Dr. Biron: Among the 16
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ABMT for Germ Cell Tumors 469 HIGH-
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ABMT for Germ Cell Tumors 471 Table
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ABMT for Germ Cell Tumors 473 Group
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ABMT for Germ Cell Tumors 475 CONCL
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Massive Chemotherapy in NSGCT 477 C
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Massive Chemotherapy in NSGCT 479 N
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Massive Chemotherapy in NSGCT 481 T
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Massive Chemotherapy in NSGCT 483 T
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Massive Chemotherapy in NSGCT 485 1
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CBDCA/VP-16 in Germ-Cell Cancer 487
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Page 517:
Page 520 and 521:
494 Testicular Cancer Dr. Biron: Ho
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496 Testicular Cancer Dr. Sorzsky:
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ABMT for Advanced Melanoma 499 TREA
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ABMT for Advanced Melanoma 501 Tabl
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ABMT for Advanced Melanoma 503 Tabl
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ABMT for Advanced Melanoma 505 agen
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SESSION III - SOLID TUMORS F. OVARI
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510 HDM and ABMT in Ovarian Carcino
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Page 540 and 541:
Page 543:
SESSION III - SOLID TUMORS G. PHASE
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520 High Dose Carboplatin TREATMENT
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522 High Dose Carboplatin ABMT. In
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G.I. Tumors 525 Discussion 5 - Sess
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SESSION IV - PEDIATRIC TUMORS A. NE
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530 Treatment of Metastatic Neurobl
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Page 560 and 561:
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BMT in Neuroblastoma 543 HIGH DOSE
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BMT in Neuroblastoma 545 lOO-i —1
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BMT in Neuroblastoma 547 100 SURVIV
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ABMT in Neuroblastoma 549 AUTOLOGOU
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O ° 4> o O ÍM -o o 00 o o in O (\
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ABMT in Neuroblastoma 553 antibodie
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•p (0 CT« O +J < 03 i) •H « c
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ABMT in Neuroblastoma 557 6. Favrot
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560 Myeloablative Treatment for Chi
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568 AutoBMT for Neuroblastoma at CH
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Neuroblastoma with Intensive Therap
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586 Neuroblastoma Dr. Philip: We us
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588 Neuroblastoma Dr. Graham-Pole:
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590 Neuroblastoma they saw relapses
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Ewing's Sarcoma Phase II Metastases
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Page 623 and 624:
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Page 628 and 629:
n o + + + + + + to in •O CM CM CM
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604 ABMT in Wilms' Tumor: An EBMT S
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606 ABMT in Wilms' Tumor: An EBMT S
Page 635 and 636:
Consolidation Therapy in Metastatic
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Page 639 and 640:
Page 641:
Page 644 and 645:
618 ABMT in Pediatric Sarcomas chem
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620 ABMT in Pediatric Sarcomas risk
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622 Sarcoma Dr. Seeger: These marro
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Effects of IL-1 on Hematopoiesis 62
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Page 655:
Page 658 and 659:
632 rhGM-CSF After Marrow Transplan
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638 IL-1 as Protection from Toxic E
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Growth Factor Therapy in Primates 6
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Differences Between Normal and Leuk
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Page 683 and 684:
rHuGM-CSF in Autologous Bone Marrow
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HuGM-CSF in Autologous Bone Marrow
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Page 693:
Page 696 and 697:
670 Growth Factors document all of
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Growth Factors 673 Discussion 2 - S
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SESSION VI - PERIPHERAL BLOOD STEM
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678 GM-CSF and PB Progenitor Cells
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Page 711 and 712:
Peripheral Blood CFU-GM and BFUe 68
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Occult Tumor in Apheresis Harvests
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Occult Tumor in Apheresis Harvests
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Stern Cell Collection and Toxicity
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Page 727:
Page 730 and 731:
704 Lymphoma and PSCT harvest. The
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706 Lymphoma and PSCT DISCUSSION Th
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708 PBSC Transplants in Solid Tumor
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Page 738 and 739:
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714 Autologous Blood Stem Cell Tran
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716 Autologous Blood Stem Cell Tran
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Peripheral Blood Stem Cells 719 TUM
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Peripheral Blood Stem Cells 721 eig
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Myeloablative Treatments in Haemato
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734 Peripheral Blood Stem Cells Dr.
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Page 766 and 767:
Page 769 and 770:
Treatment of Cytomegalovirus Pneumo
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Treatment of Cytomegalovirus Pneumo
Page 773 and 774:
Viral Infection in BMT 747 VIRAL IN
Page 775 and 776:
Viral Infection in BMT 749 Table 1.
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Viral Infection in BMT 751 REFERENC
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754 IV+PO Ig in ABMT incidence of i
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756 IV+PO Ig in ABMT Table 2. Posit
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758 IV+PO Ig in ABMT Approaches for
Page 786 and 787:
760 Supportive Care away with that.
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Merocyanine 540 763 MEROCYANINE 540
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Merocyanine 540 765 Table 1. Merocy
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Merocyanine 540 767 9. Kalyanaraman
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770 Purging with Aldophosphamide Ac
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Further Developments in Purging 779
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Page 809:
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786 Further Developments in Purging
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Page 819 and 820:
PARMA International Protocol 793 PA
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PARMA International Protocol 795 Wk
Page 823 and 824:
PARMA International Protocol 797 gr
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Double ABMT in Advanced Neuroblasto
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Page 834 and 835:
808 General Discussion to pathologi
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SUMMARY
Page 840 and 841:
814 Autotransplants: Acute Leukemia
Page 842 and 843:
576 Autotransplants: Acute Leukemia
Page 845 and 846:
819 Contributors and Participants M
Page 847 and 848:
821 Kenneth A. Ault, Maine Cytometr
Page 849 and 850:
823 B. J. Bolwell, Cleveland Clinic
Page 851 and 852:
825 Myra W. Chang, Department of He
Page 853 and 854:
827 J. Crown, Memorial Sloan-Ketter
Page 855 and 856:
829 Carol L. Epstein, Immunex Resea
Page 857 and 858:
831 Maria Vittoria Gazzola, Unita 1
Page 859 and 860:
833 Mildred S. Hanson, Tumor Immuno
Page 861 and 862:
835 Herbert Kaizer, Rush-Presbyteri
Page 863 and 864:
837 Eric Lepage, Institut d 1 Hemat
Page 865 and 866:
839 Michel Marty, Département de C
Page 867 and 868:
841 J. Myers, Memorial Sloan-Ketter
Page 869 and 870:
843 C. R. Pinkerton, Department of
Page 871 and 872:
845 Rein Sarai, The Johns Hopkins U
Page 873 and 874:
847 J. J. Sotto, C.H.R.U. Orenoble,
Page 875 and 876:
849 Guido Tricot, Department of Med
Page 877:
851 J.R. Zucali, Department of Medi
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