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High Dose Consolidation Therapy with Autologous Stem Cell Rescue in Stage IV Breast Cancer: A Preliminary Report 371 Stephanie F. Williams, Rosemarie Mick, and Jacob D. Bitran STAMP Studies of High Dose Chemotherapy in Breast Cancer 377 Karen H. Antman, J. Paul Eder, Anthony Elias, Thomas C. Shea, Beverly A. Teicher, W. David Henner, Susan M. Schryber, Robert Finberg, Jonathan Critchlow, Colin Begg, Myla Hunt, Kenneth Anderson, Lowell E. Schnipper, and Emil Frei III DISCUSSION 1 385 Dose Intensification Using High-Dose Combination Alkylating Agents and Autologous Bone Marrow Support for the Treatment of Breast Cancer 389 William P. Peters, Roy B. Jones, Elizabeth J. Shpall, and Jeffrey Shogan High-Dose Intensification for Stage IV Hormonally-Refractory Breast Cancer 399 Gary Spitzer, Frank R. Dunphy II, James K. Ellis, Aman U. Buzdar, Gabriel N. Hortobagyi, Frankie A. Holmes, Khaled W. Jabboury, Leonard J. Horwitz, Sundar Jagannath, and Karel A. Dicke Autologous Bone Marrow Transplantation and Hematopoietic Recovery in Solid Tumors 405 Frank R. Dunphy II, Gary Spitzer, James K. Ellis, Karel A. Dicke, Aman U. Buzdar, and Gabriel N. Hortobagyi B. MINIMAL RESIDUAL DISEASE Bone Marrow Metastases in Small Cell Lung Cancer: Detection with Magnetic Resonance Imaging and Monoclonal Antibodies 413 Véronique Trillet, Didier Revel, Valérie Combaret, Marie Favrot, Robert Loire, Alain Tabib, Jacqueline Pages, Pierre Jacquemet, Alain Bonmartin, Jean Francois Mornex, Jean Francois Cordier, Michel Amiel, Francois Pinet, and Jean Brune Recent Progress in the Detection of Metastatic Tumor in Bone Marrow by Culture Techniques 421 J. Graham Sharp, James Armitage, David Crouse, Shantaram Joshi, Anne Kessinger, Sally Mann, William Vaughan, and Dennis Weisenburger xii
Breast Tumor Cell Detection in Marrow 427 Mark Owen, Mokhtar Taha, Sulabha Kulkarni, Nelson Ordonez, Gabriel Hortobagyi, Christopher Reading, Karel Dicke, and Gary Spitzer DISCUSSION 2 431 C. GLIOMAS High Dose BCNU and ABMT, Surgery and Radiotherapy in Gliomas 437 P. Biron, F. Mornex, P. Colombat, C. Vial, F. Chauvin, M. Veyssere, I. Philip, and T. Philip High-Dose Chemotherapy with Autologous Marrow Rescue in Children with Recurrent Brain Tumors 449 Jonathan Finlay, Charles August, Roger Packer, Robert Zimmerman, Leslie Sutton, James Nachman, Allan Levin, Patrick Turski, Richard Steeves, Walter Longo, and Manucher Javid Adjuvant High-Dose BCNU and Autologous Bone Marrow Transplantation for High-Grade Malignant Gliomas 457 David B. Johnson, James M. Thompson, James A. Corwin, M. Timothy Smith, R. A. de los Reyes, Mary B. Daly, David Lamaster, Richard S. Leff, Richard Mercier, and Gerald L. Messerschmidt DISCUSSION 3 463 D. TESTICULAR High-Dose Chemotherapy with Autologous Bone Marrow Transplantation for Poor Diagnosis Non-Seminomatous Germ Cell Tumors 469 José-Luis Pico, Jean-Pierre Droz, Maurice Ostronoff, Daniel Baume, Alain Gouyette, Françoise Beaujean, and Marcel Hayat Centre Leon Berard Experience of Massive Chemotherapy in Non- Seminomatous Germ Cell Tumours (NSGCT): Analysis of First Regimens in Progressive Disease and VP16-IPM-CDDP (VIC) in Sensitive Patients 477 P. Biron, M. Brunat-Mentigny, J. Y. Bayle, M. Clavel, J. P. Guastalla, E. Bouffet, I. Philip, F. Chauvin, and T. Philip xiii
Page 1: Autologous Bone Marrow transplantat
Page 5 and 6: AUTOLOGOUS BONE MARROW TRANSPLANTAT
Page 7 and 8: Contents Preface xxi Acknowledgment
Page 9 and 10: High Dose Etoposide, Melphalan, Tot
Page 11 and 12: High-Dose Therapy and Autologous Bo
Page 13: Autologous Bone Marrow Transplantat
Page 17 and 18: High Dose Chemo-Radiotherapy with B
Page 19 and 20: The Use of Recombinant Human Granul
Page 21: Session VIII - Further Developments
Page 25: Acknowledgments Publication of thes
Page 29 and 30: CBV and ABMT for AML in CRI 3 DOES
Page 31 and 32: CBV and ABUT for AML in CR1 5 Bone
Page 33 and 34: CBV and ABMT for AML in CR1 7 27 36
Page 35 and 36: CBV and ABMT for AML in CR1 Table 3
Page 37 and 38: CBV and ABMT for AML in CRI 11 ACKN
Page 39 and 40: Mafosfamide Purging in Acute Leukem
Page 47 and 48: Timing of BMT for ANL 21 TIMING OF
Page 49 and 50: Timing of BMT for ANL 23 Unlike che
Page 51 and 52: Timing of BMT for ANL 25 autologous
Page 53 and 54: Timing of Bone Marrow Transplantati
Page 55 and 56: Merocyanine-540 and Mafosfamide Pur
Page 57 and 58: Merocyanine-540 and Mafosfamide Pur
Page 59: Merocyaniñe-540 and Mafosfamide Pu
Page 62 and 63: Sensitivity of Leukemic Progenitors
Page 64 and 65:
38 Sensitivity of Leukemic Progenit
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ABMT for Consolidation of AML/ALL i
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56 Hematopoietic Progenitor Selecti
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62 Acute Leukemia - AML (Purging) (
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64 Acute Leukemia - AML (Purging) T
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4HC/VCR Chemopurge 67 CHEMOPURGE WI
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4HC/VCR Chemopurge 69 Table 1. Pati
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4HC/VCR Chemopurge 71 remain in rem
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Autologous BMT for ANLL 73 AUTOLOGO
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Autologous BMT for ANLL 75 Hematolo
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Autologous BMT for ANLL 77 in CR2 o
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Clinical Value of Auto BMT 79 Discu
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BAVC and ABMT in AML Patients 81 BA
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BAVC and ABMT in AML Patients 83 Bo
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BAVC and ABMT in AML Patients 85 Ta
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ABMT in Advanced ALL 87 RESULTS OF
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ABMT in Advanced ALL 89 After hemat
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ABMT in Advanced ALL 91 Two differe
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94 Autograft for AML Since no concl
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96 Autograft for AML 8 16 24 32 40
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98 Autograft for AML relapse free p
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Etoposide, Melphalan, TBI and ABMT
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Page 131:
Page 134 and 135:
108 J In Vitro/In Vivo Treatment of
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110 In Vitro/In Vivo Treatment of L
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112 In Vitro/In Vivo Treatment of L
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114 BU/CY in BMT CY alone is not an
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116 BU/CY in BMT BU CY PREPARATIVE
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118 BU/CY in BMT autologous or allo
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120 Double AML Transplants consolid
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122 Double AML Transplants 100 Even
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124 Double AML Transplants There is
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126 Double Transplants and 21 had a
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128 Double Transplants (ALL) and fu
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130 Double Transplants PROSPECTIVE
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132 Double Transplants months (22-7
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Autologous vs. Allogeneic Transplan
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SESSION I - LEUKEMIA B. ACUTE LEUKE
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140 ABMT vs. Chemotherapy in High R
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Page 170 and 171:
Page 172 and 173:
146 Marrow Transplantation for ALL
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148 Marrow Transplantation for ALL
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ABMT Italian Study for Childhood AL
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ABMT Italian Study for Childhood AL
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Autologous Transplant for ALL 155 A
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Autologous Transplant for ALL 157 R
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Autologous Transplant for ALL 159 n
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ABMT in ALL 161 AUTOLOGOUS BONE MAR
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ABMT in ALL 163 10< 5
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ABMT in ALL 165 NATIONAL SWEDISH AL
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ABMT in ALL 167 AUTOLOGOUS BONE MAR
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ABMT in ALL 169 98 X tlx 7IX (IX SI
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172 B43/CD19 PAP IT Table 1. Expres
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174 B43/CD19 PAP IT dialyzed, and f
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Figure 2. Biochemical Analysis of B
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178 B43/CD19 PAP IT 15. Uckun FM, K
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180 Detection of Minimal Residual D
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Page 212 and 213:
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188 Autologous BMT vs. Chemotherapy
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190 Autologous BMT vs. Chemotherapy
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192 Autologous vs. Allogeneic Trans
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194 Timing & Conditioning Regimens
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196 Timing & Conditioning Regimens
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Purging with Anti-B Cell MoAb and C
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NO o 1—* c\i (M (M *— irt o •
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Front Line Chemotherapy Regimens 20
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•o tí id O IN GO ai o- CD «-
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CA CA 3 CU 4-» CD > t_ *-> CD C/l
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218 Optimal Timing for ABMT in Non-
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ABMT in NHL and HD — Timing of Th
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ABMT in NHL and HD - - Timing of Th
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ABUT in NHL and HD — Timing of Th
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The Role of Intensive Chemotherapy
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(H S m ¡3 < Xi •P •ri Se X tri
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Page 268 and 269:
242 Optimal Timing for Intermediate
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244 Optimal Timing for Intermediate
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BMT for Lymphoblastic Lymphoma 247
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High Dose Therapy for Multiple Myel
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Hodgkin's Disease, ABMT 261 OPTIMAL
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Hodgkin's Disease, ABMT 263 Table 1
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Hodgkin's Disease, ABMT 265 Table 3
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Hodgkin's Disease, ABMT 267 REFEREN
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270 Timing of ABMT in Hodgkin's Dis
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272 Timing of ABMT in Hodgkin's Dis
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Timing of CBV and Autologous BMT 27
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286 High Dose Chemotherapy Regimens
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Optimal Timing for Lymphoblastic Ly
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Optimal Timing for Lymphoblastic Ly
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298 Optimal Timing for Hodgkin's TB
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300 BMT Preparative Regimens marrow
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302 BMT Preparative Regimens As can
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Conditioning for AuBMT in NHL 305 A
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Conditioning for AuBMT in NHL 307 T
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Conditioning for AuBMT in NHL 309 e
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Escalating Dose CBV in Lymphoma 311
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Page 341:
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318 High Dose Chemotherapy with ABM
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3 CD + i— ro
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ABMT in Low Grade NHL 327 AUTOLOGOU
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ABMT in Low Grade NHL 329 ABMT Foll
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Purging and Relapse in BL 331 EX-VI
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CD "O + >- CO CU c/l TJ a. CO CI C
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CO u- 3 < H CD < £ £¡ cf 25 3 <
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Purging and Relapse in BL 337 BM af
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Detection of MRD by PCR 339 DETECTI
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Detection of MRD by PCR 341 Figure
Page 369:
Detection of MRD by PCR 343 results
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346 Conditioning Regimens in Lympho
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348 Conditioning Regimens in Lympho
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Studies in Indolent Lymphoma 351 Di
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354 Detection of Disease & Purging
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ABMT as Intensification in Breast C
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ABMT as Intensification in Breast C
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AB MT as Intensification in Breast
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364 Breast Cancer: Autologous Bone
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366 Breast Cancer: Autologous Bone
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368 High Dose Chemotherapy in Breas
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370 High Dose Chemotherapy in Breas
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372 High Dose Consolidation in Brea
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Page 402 and 403:
Page 404 and 405:
378 STAMP Studies in Breast Cancer
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CO •p fi 0) •rl •P id tU o o
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STAMP Studies in Breast Cancer 383
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386 Solid Tumors I: Breast clearly
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388 Solid Tumors I: Breast cannot i
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390 Dose Intensification for the Tr
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High-Dose Intensification for Breas
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406 ABMT and Hematopoietic Recovery
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Page 436 and 437:
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Bone Marrow Metastases in Small Cel
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Page 443 and 444:
Page 445:
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422 Occult Tumor in Bone Marrow RES
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424 Occult Tumor in Bone Marrow Tab
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Breast Tumor Cell Detection 427 BRE
Page 455 and 456:
Breast Tumor Cell Detection 429 Nex
Page 457 and 458:
Breast Cancer 431 Discussion 2 - Se
Page 459:
Breast Cancer 433 Dr. Peters: We we
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Various Treatments in Gliomas 437 H
Page 465 and 466:
Various Treatments in Gliomas 439 T
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Various Treatments in Gliomas 441 T
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Various Treatments in Gliomas 443 (
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Various Treatments in Gliomas 445 G
Page 473:
Various Treatments in Gliomas 447 d
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m í. o O ._• E CU c I co CJ M X
Page 478 and 479:
452 ABMT in Pediatric Brain Tumors
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454 ABMT in Pediatric Brain Tumors
Page 483 and 484:
Adjuvant High-Dose BCNU and BMT for
Page 485 and 486:
Page 487:
Page 490 and 491:
464 Gliomas Dr. Biron: It is so dif
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466 Gliomas Dr. Biron: Among the 16
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ABMT for Germ Cell Tumors 469 HIGH-
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ABMT for Germ Cell Tumors 471 Table
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ABMT for Germ Cell Tumors 473 Group
Page 501 and 502:
ABMT for Germ Cell Tumors 475 CONCL
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Massive Chemotherapy in NSGCT 477 C
Page 505 and 506:
Massive Chemotherapy in NSGCT 479 N
Page 507 and 508:
Massive Chemotherapy in NSGCT 481 T
Page 509 and 510:
Massive Chemotherapy in NSGCT 483 T
Page 511 and 512:
Massive Chemotherapy in NSGCT 485 1
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CBDCA/VP-16 in Germ-Cell Cancer 487
Page 515 and 516:
Page 517:
Page 520 and 521:
494 Testicular Cancer Dr. Biron: Ho
Page 522 and 523:
496 Testicular Cancer Dr. Sorzsky:
Page 525 and 526:
ABMT for Advanced Melanoma 499 TREA
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ABMT for Advanced Melanoma 501 Tabl
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ABMT for Advanced Melanoma 503 Tabl
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ABMT for Advanced Melanoma 505 agen
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SESSION III - SOLID TUMORS F. OVARI
Page 536 and 537:
510 HDM and ABMT in Ovarian Carcino
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Page 540 and 541:
Page 543:
SESSION III - SOLID TUMORS G. PHASE
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520 High Dose Carboplatin TREATMENT
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522 High Dose Carboplatin ABMT. In
Page 551 and 552:
G.I. Tumors 525 Discussion 5 - Sess
Page 553:
SESSION IV - PEDIATRIC TUMORS A. NE
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530 Treatment of Metastatic Neurobl
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Page 560 and 561:
Page 562 and 563:
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Page 566 and 567:
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BMT in Neuroblastoma 543 HIGH DOSE
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BMT in Neuroblastoma 545 lOO-i —1
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BMT in Neuroblastoma 547 100 SURVIV
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ABMT in Neuroblastoma 549 AUTOLOGOU
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O ° 4> o O ÍM -o o 00 o o in O (\
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ABMT in Neuroblastoma 553 antibodie
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•p (0 CT« O +J < 03 i) •H « c
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ABMT in Neuroblastoma 557 6. Favrot
Page 586 and 587:
560 Myeloablative Treatment for Chi
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Page 592 and 593:
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568 AutoBMT for Neuroblastoma at CH
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Neuroblastoma with Intensive Therap
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Page 609:
Page 612 and 613:
586 Neuroblastoma Dr. Philip: We us
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588 Neuroblastoma Dr. Graham-Pole:
Page 616 and 617:
590 Neuroblastoma they saw relapses
Page 619 and 620:
Ewing's Sarcoma Phase II Metastases
Page 621 and 622:
Page 623 and 624:
Page 625:
Page 628 and 629:
n o + + + + + + to in •O CM CM CM
Page 630 and 631:
604 ABMT in Wilms' Tumor: An EBMT S
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606 ABMT in Wilms' Tumor: An EBMT S
Page 635 and 636:
Consolidation Therapy in Metastatic
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Page 639 and 640:
Page 641:
Page 644 and 645:
618 ABMT in Pediatric Sarcomas chem
Page 646 and 647:
620 ABMT in Pediatric Sarcomas risk
Page 648 and 649:
622 Sarcoma Dr. Seeger: These marro
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Effects of IL-1 on Hematopoiesis 62
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Page 655:
Page 658 and 659:
632 rhGM-CSF After Marrow Transplan
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638 IL-1 as Protection from Toxic E
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Page 668 and 669:
Page 671 and 672:
Growth Factor Therapy in Primates 6
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Page 675 and 676:
Page 677 and 678:
Differences Between Normal and Leuk
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Page 681 and 682:
Page 683 and 684:
rHuGM-CSF in Autologous Bone Marrow
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HuGM-CSF in Autologous Bone Marrow
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Page 689 and 690:
Page 691 and 692:
Page 693:
Page 696 and 697:
670 Growth Factors document all of
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Growth Factors 673 Discussion 2 - S
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SESSION VI - PERIPHERAL BLOOD STEM
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678 GM-CSF and PB Progenitor Cells
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Page 708 and 709:
Page 711 and 712:
Peripheral Blood CFU-GM and BFUe 68
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Page 715 and 716:
Page 717 and 718:
Page 719 and 720:
Occult Tumor in Apheresis Harvests
Page 721 and 722:
Occult Tumor in Apheresis Harvests
Page 723 and 724:
Stern Cell Collection and Toxicity
Page 725 and 726:
Page 727:
Page 730 and 731:
704 Lymphoma and PSCT harvest. The
Page 732 and 733:
706 Lymphoma and PSCT DISCUSSION Th
Page 734 and 735:
708 PBSC Transplants in Solid Tumor
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Page 738 and 739:
Page 740 and 741:
714 Autologous Blood Stem Cell Tran
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716 Autologous Blood Stem Cell Tran
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Peripheral Blood Stem Cells 719 TUM
Page 747 and 748:
Peripheral Blood Stem Cells 721 eig
Page 749 and 750:
Myeloablative Treatments in Haemato
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Page 755 and 756:
Page 757:
Page 760 and 761:
734 Peripheral Blood Stem Cells Dr.
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Page 766 and 767:
Page 769 and 770:
Treatment of Cytomegalovirus Pneumo
Page 771 and 772:
Treatment of Cytomegalovirus Pneumo
Page 773 and 774:
Viral Infection in BMT 747 VIRAL IN
Page 775 and 776:
Viral Infection in BMT 749 Table 1.
Page 777:
Viral Infection in BMT 751 REFERENC
Page 780 and 781:
754 IV+PO Ig in ABMT incidence of i
Page 782 and 783:
756 IV+PO Ig in ABMT Table 2. Posit
Page 784 and 785:
758 IV+PO Ig in ABMT Approaches for
Page 786 and 787:
760 Supportive Care away with that.
Page 789 and 790:
Merocyanine 540 763 MEROCYANINE 540
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Merocyanine 540 765 Table 1. Merocy
Page 793:
Merocyanine 540 767 9. Kalyanaraman
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770 Purging with Aldophosphamide Ac
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Page 805 and 806:
Further Developments in Purging 779
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Page 809:
Page 812 and 813:
786 Further Developments in Purging
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Page 816 and 817:
Page 819 and 820:
PARMA International Protocol 793 PA
Page 821 and 822:
PARMA International Protocol 795 Wk
Page 823 and 824:
PARMA International Protocol 797 gr
Page 825 and 826:
Double ABMT in Advanced Neuroblasto
Page 827 and 828:
Page 829 and 830:
Page 831:
Page 834 and 835:
808 General Discussion to pathologi
Page 837:
SUMMARY
Page 840 and 841:
814 Autotransplants: Acute Leukemia
Page 842 and 843:
576 Autotransplants: Acute Leukemia
Page 845 and 846:
819 Contributors and Participants M
Page 847 and 848:
821 Kenneth A. Ault, Maine Cytometr
Page 849 and 850:
823 B. J. Bolwell, Cleveland Clinic
Page 851 and 852:
825 Myra W. Chang, Department of He
Page 853 and 854:
827 J. Crown, Memorial Sloan-Ketter
Page 855 and 856:
829 Carol L. Epstein, Immunex Resea
Page 857 and 858:
831 Maria Vittoria Gazzola, Unita 1
Page 859 and 860:
833 Mildred S. Hanson, Tumor Immuno
Page 861 and 862:
835 Herbert Kaizer, Rush-Presbyteri
Page 863 and 864:
837 Eric Lepage, Institut d 1 Hemat
Page 865 and 866:
839 Michel Marty, Département de C
Page 867 and 868:
841 J. Myers, Memorial Sloan-Ketter
Page 869 and 870:
843 C. R. Pinkerton, Department of
Page 871 and 872:
845 Rein Sarai, The Johns Hopkins U
Page 873 and 874:
847 J. J. Sotto, C.H.R.U. Orenoble,
Page 875 and 876:
849 Guido Tricot, Department of Med
Page 877:
851 J.R. Zucali, Department of Medi
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