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22 Timing of BMT for ANL Table 1. Results of Selected Large Studies of Treatment of Adults with ANL in CR Form of Therapy Chemotherapy Consolidation Maintenance No. of CR pts % in CCR Source None None +/-DAT +/-DAT DAT None Ara-C* Ara-C* Ara-C, 6TG Various Ara-C, 6TG Various 151 25% @ 60 mo Rai et al, 1981 1 356 22% @ 36 mo Yates et al, 1982 2 146 21% @ 24 mo Cassileth et al, 1984 3 374 24% i §> 36 mo Buchner et al, 1985 4 757 20%
Timing of BMT for ANL 23 Unlike chemotherapy, marrow transplantation can cure some patients who have relapsed from initial chemotherapy. From Seattle we reported that five-year disease-free survival was 30% for 54 patients transplanted during untreated first relapse, 28% for 49 patients transplanted during second remission, and 21% for 29 patients transplanted while in chemotherapy-resistant relapse (7,11). These results have several implications. First, there is no reason to delay transplant beyond first relapse or second remission, since results deteriorate. Second, since the outcome in first relapse is as good as in second remission, there is no apparent reason to subject first relapse patients to reinduction prior to marrow transplantation, since some may not achieve a complete remission, and those that do are not better candidates than they were prior to reinduction. Of course there may be important logistic problems such as identifying a donor, finding a transplant bed, and arranging financing, which may delay transplantation, therefore requiring further chemotherapy to maintain the patient until transplantation. The third implication of results of salvage transplantation is that a strategy of initial chemotherapy, followed by transplantation at the time of first relapse, may yield an outcome almost as good as transplantation during first remission. This is illustrated in Figure 1. Shown are the outcome of marrow transplantation in 220 patients transplanted in first remission in Seattle, and the outcome of 392 patients
Page 1: Autologous Bone Marrow transplantat
Page 5 and 6: AUTOLOGOUS BONE MARROW TRANSPLANTAT
Page 7 and 8: Contents Preface xxi Acknowledgment
Page 9 and 10: High Dose Etoposide, Melphalan, Tot
Page 11 and 12: High-Dose Therapy and Autologous Bo
Page 13 and 14: Autologous Bone Marrow Transplantat
Page 15 and 16: Breast Tumor Cell Detection in Marr
Page 17 and 18: High Dose Chemo-Radiotherapy with B
Page 19 and 20: The Use of Recombinant Human Granul
Page 21: Session VIII - Further Developments
Page 25: Acknowledgments Publication of thes
Page 29 and 30: CBV and ABMT for AML in CRI 3 DOES
Page 31 and 32: CBV and ABUT for AML in CR1 5 Bone
Page 33 and 34: CBV and ABMT for AML in CR1 7 27 36
Page 35 and 36: CBV and ABMT for AML in CR1 Table 3
Page 37 and 38: CBV and ABMT for AML in CRI 11 ACKN
Page 39 and 40: Mafosfamide Purging in Acute Leukem
Page 47: Timing of BMT for ANL 21 TIMING OF
Page 51 and 52: Timing of BMT for ANL 25 autologous
Page 53 and 54: Timing of Bone Marrow Transplantati
Page 55 and 56: Merocyanine-540 and Mafosfamide Pur
Page 57 and 58: Merocyanine-540 and Mafosfamide Pur
Page 59: Merocyaniñe-540 and Mafosfamide Pu
Page 62 and 63: Sensitivity of Leukemic Progenitors
Page 64 and 65: 38 Sensitivity of Leukemic Progenit
Page 67 and 68: ABMT for Consolidation of AML/ALL i
Page 79: ABMT for Consolidation of AML/ALL i
Page 82 and 83: 56 Hematopoietic Progenitor Selecti
Page 88 and 89: 62 Acute Leukemia - AML (Purging) (
Page 90 and 91: 64 Acute Leukemia - AML (Purging) T
Page 93 and 94: 4HC/VCR Chemopurge 67 CHEMOPURGE WI
Page 95 and 96: 4HC/VCR Chemopurge 69 Table 1. Pati
Page 97 and 98: 4HC/VCR Chemopurge 71 remain in rem
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Autologous BMT for ANLL 73 AUTOLOGO
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Autologous BMT for ANLL 75 Hematolo
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Autologous BMT for ANLL 77 in CR2 o
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Clinical Value of Auto BMT 79 Discu
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BAVC and ABMT in AML Patients 81 BA
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BAVC and ABMT in AML Patients 83 Bo
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BAVC and ABMT in AML Patients 85 Ta
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ABMT in Advanced ALL 87 RESULTS OF
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ABMT in Advanced ALL 89 After hemat
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ABMT in Advanced ALL 91 Two differe
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94 Autograft for AML Since no concl
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96 Autograft for AML 8 16 24 32 40
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98 Autograft for AML relapse free p
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Etoposide, Melphalan, TBI and ABMT
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108 J In Vitro/In Vivo Treatment of
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110 In Vitro/In Vivo Treatment of L
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112 In Vitro/In Vivo Treatment of L
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114 BU/CY in BMT CY alone is not an
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116 BU/CY in BMT BU CY PREPARATIVE
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118 BU/CY in BMT autologous or allo
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120 Double AML Transplants consolid
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122 Double AML Transplants 100 Even
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124 Double AML Transplants There is
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126 Double Transplants and 21 had a
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128 Double Transplants (ALL) and fu
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130 Double Transplants PROSPECTIVE
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132 Double Transplants months (22-7
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Autologous vs. Allogeneic Transplan
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SESSION I - LEUKEMIA B. ACUTE LEUKE
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140 ABMT vs. Chemotherapy in High R
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146 Marrow Transplantation for ALL
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148 Marrow Transplantation for ALL
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ABMT Italian Study for Childhood AL
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ABMT Italian Study for Childhood AL
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Autologous Transplant for ALL 155 A
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Autologous Transplant for ALL 157 R
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Autologous Transplant for ALL 159 n
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ABMT in ALL 161 AUTOLOGOUS BONE MAR
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ABMT in ALL 163 10< 5
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ABMT in ALL 165 NATIONAL SWEDISH AL
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ABMT in ALL 167 AUTOLOGOUS BONE MAR
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ABMT in ALL 169 98 X tlx 7IX (IX SI
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172 B43/CD19 PAP IT Table 1. Expres
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174 B43/CD19 PAP IT dialyzed, and f
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Figure 2. Biochemical Analysis of B
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178 B43/CD19 PAP IT 15. Uckun FM, K
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180 Detection of Minimal Residual D
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188 Autologous BMT vs. Chemotherapy
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190 Autologous BMT vs. Chemotherapy
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192 Autologous vs. Allogeneic Trans
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194 Timing & Conditioning Regimens
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196 Timing & Conditioning Regimens
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Purging with Anti-B Cell MoAb and C
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NO o 1—* c\i (M (M *— irt o •
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Front Line Chemotherapy Regimens 20
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•o tí id O IN GO ai o- CD «-
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CA CA 3 CU 4-» CD > t_ *-> CD C/l
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218 Optimal Timing for ABMT in Non-
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ABMT in NHL and HD — Timing of Th
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ABMT in NHL and HD - - Timing of Th
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ABUT in NHL and HD — Timing of Th
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The Role of Intensive Chemotherapy
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(H S m ¡3 < Xi •P •ri Se X tri
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242 Optimal Timing for Intermediate
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244 Optimal Timing for Intermediate
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BMT for Lymphoblastic Lymphoma 247
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High Dose Therapy for Multiple Myel
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Hodgkin's Disease, ABMT 261 OPTIMAL
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Hodgkin's Disease, ABMT 263 Table 1
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Hodgkin's Disease, ABMT 265 Table 3
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Hodgkin's Disease, ABMT 267 REFEREN
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270 Timing of ABMT in Hodgkin's Dis
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272 Timing of ABMT in Hodgkin's Dis
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Timing of CBV and Autologous BMT 27
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286 High Dose Chemotherapy Regimens
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Optimal Timing for Lymphoblastic Ly
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Optimal Timing for Lymphoblastic Ly
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298 Optimal Timing for Hodgkin's TB
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300 BMT Preparative Regimens marrow
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302 BMT Preparative Regimens As can
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Conditioning for AuBMT in NHL 305 A
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Conditioning for AuBMT in NHL 307 T
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Conditioning for AuBMT in NHL 309 e
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Escalating Dose CBV in Lymphoma 311
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318 High Dose Chemotherapy with ABM
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3 CD + i— ro
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ABMT in Low Grade NHL 327 AUTOLOGOU
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ABMT in Low Grade NHL 329 ABMT Foll
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Purging and Relapse in BL 331 EX-VI
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CD "O + >- CO CU c/l TJ a. CO CI C
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CO u- 3 < H CD < £ £¡ cf 25 3 <
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Purging and Relapse in BL 337 BM af
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Detection of MRD by PCR 339 DETECTI
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Detection of MRD by PCR 341 Figure
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Detection of MRD by PCR 343 results
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346 Conditioning Regimens in Lympho
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348 Conditioning Regimens in Lympho
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Studies in Indolent Lymphoma 351 Di
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354 Detection of Disease & Purging
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ABMT as Intensification in Breast C
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ABMT as Intensification in Breast C
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AB MT as Intensification in Breast
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364 Breast Cancer: Autologous Bone
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366 Breast Cancer: Autologous Bone
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368 High Dose Chemotherapy in Breas
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370 High Dose Chemotherapy in Breas
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372 High Dose Consolidation in Brea
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378 STAMP Studies in Breast Cancer
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CO •p fi 0) •rl •P id tU o o
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STAMP Studies in Breast Cancer 383
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386 Solid Tumors I: Breast clearly
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388 Solid Tumors I: Breast cannot i
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390 Dose Intensification for the Tr
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High-Dose Intensification for Breas
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406 ABMT and Hematopoietic Recovery
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Bone Marrow Metastases in Small Cel
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422 Occult Tumor in Bone Marrow RES
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424 Occult Tumor in Bone Marrow Tab
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Breast Tumor Cell Detection 427 BRE
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Breast Tumor Cell Detection 429 Nex
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Breast Cancer 431 Discussion 2 - Se
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Breast Cancer 433 Dr. Peters: We we
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Various Treatments in Gliomas 437 H
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Various Treatments in Gliomas 439 T
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Various Treatments in Gliomas 441 T
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Various Treatments in Gliomas 443 (
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Various Treatments in Gliomas 445 G
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Various Treatments in Gliomas 447 d
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m í. o O ._• E CU c I co CJ M X
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452 ABMT in Pediatric Brain Tumors
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454 ABMT in Pediatric Brain Tumors
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Adjuvant High-Dose BCNU and BMT for
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464 Gliomas Dr. Biron: It is so dif
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466 Gliomas Dr. Biron: Among the 16
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ABMT for Germ Cell Tumors 469 HIGH-
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ABMT for Germ Cell Tumors 471 Table
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ABMT for Germ Cell Tumors 473 Group
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ABMT for Germ Cell Tumors 475 CONCL
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Massive Chemotherapy in NSGCT 477 C
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Massive Chemotherapy in NSGCT 479 N
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Massive Chemotherapy in NSGCT 481 T
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Massive Chemotherapy in NSGCT 483 T
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Massive Chemotherapy in NSGCT 485 1
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CBDCA/VP-16 in Germ-Cell Cancer 487
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494 Testicular Cancer Dr. Biron: Ho
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496 Testicular Cancer Dr. Sorzsky:
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ABMT for Advanced Melanoma 499 TREA
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ABMT for Advanced Melanoma 501 Tabl
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ABMT for Advanced Melanoma 503 Tabl
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ABMT for Advanced Melanoma 505 agen
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SESSION III - SOLID TUMORS F. OVARI
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510 HDM and ABMT in Ovarian Carcino
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SESSION III - SOLID TUMORS G. PHASE
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520 High Dose Carboplatin TREATMENT
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522 High Dose Carboplatin ABMT. In
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G.I. Tumors 525 Discussion 5 - Sess
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SESSION IV - PEDIATRIC TUMORS A. NE
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530 Treatment of Metastatic Neurobl
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BMT in Neuroblastoma 543 HIGH DOSE
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BMT in Neuroblastoma 545 lOO-i —1
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BMT in Neuroblastoma 547 100 SURVIV
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ABMT in Neuroblastoma 549 AUTOLOGOU
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O ° 4> o O ÍM -o o 00 o o in O (\
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ABMT in Neuroblastoma 553 antibodie
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•p (0 CT« O +J < 03 i) •H « c
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ABMT in Neuroblastoma 557 6. Favrot
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560 Myeloablative Treatment for Chi
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568 AutoBMT for Neuroblastoma at CH
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Neuroblastoma with Intensive Therap
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586 Neuroblastoma Dr. Philip: We us
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588 Neuroblastoma Dr. Graham-Pole:
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590 Neuroblastoma they saw relapses
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Ewing's Sarcoma Phase II Metastases
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n o + + + + + + to in •O CM CM CM
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604 ABMT in Wilms' Tumor: An EBMT S
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606 ABMT in Wilms' Tumor: An EBMT S
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Consolidation Therapy in Metastatic
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618 ABMT in Pediatric Sarcomas chem
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620 ABMT in Pediatric Sarcomas risk
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622 Sarcoma Dr. Seeger: These marro
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Effects of IL-1 on Hematopoiesis 62
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632 rhGM-CSF After Marrow Transplan
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638 IL-1 as Protection from Toxic E
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Growth Factor Therapy in Primates 6
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Differences Between Normal and Leuk
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rHuGM-CSF in Autologous Bone Marrow
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HuGM-CSF in Autologous Bone Marrow
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670 Growth Factors document all of
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Growth Factors 673 Discussion 2 - S
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SESSION VI - PERIPHERAL BLOOD STEM
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678 GM-CSF and PB Progenitor Cells
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Peripheral Blood CFU-GM and BFUe 68
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Occult Tumor in Apheresis Harvests
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Occult Tumor in Apheresis Harvests
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Stern Cell Collection and Toxicity
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704 Lymphoma and PSCT harvest. The
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706 Lymphoma and PSCT DISCUSSION Th
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708 PBSC Transplants in Solid Tumor
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714 Autologous Blood Stem Cell Tran
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716 Autologous Blood Stem Cell Tran
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Peripheral Blood Stem Cells 719 TUM
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Peripheral Blood Stem Cells 721 eig
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Myeloablative Treatments in Haemato
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734 Peripheral Blood Stem Cells Dr.
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Treatment of Cytomegalovirus Pneumo
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Treatment of Cytomegalovirus Pneumo
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Viral Infection in BMT 747 VIRAL IN
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Viral Infection in BMT 749 Table 1.
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Viral Infection in BMT 751 REFERENC
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754 IV+PO Ig in ABMT incidence of i
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756 IV+PO Ig in ABMT Table 2. Posit
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758 IV+PO Ig in ABMT Approaches for
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760 Supportive Care away with that.
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Merocyanine 540 763 MEROCYANINE 540
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Merocyanine 540 765 Table 1. Merocy
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Merocyanine 540 767 9. Kalyanaraman
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770 Purging with Aldophosphamide Ac
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Further Developments in Purging 779
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786 Further Developments in Purging
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PARMA International Protocol 793 PA
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PARMA International Protocol 795 Wk
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PARMA International Protocol 797 gr
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Double ABMT in Advanced Neuroblasto
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808 General Discussion to pathologi
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SUMMARY
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814 Autotransplants: Acute Leukemia
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576 Autotransplants: Acute Leukemia
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819 Contributors and Participants M
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821 Kenneth A. Ault, Maine Cytometr
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823 B. J. Bolwell, Cleveland Clinic
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825 Myra W. Chang, Department of He
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827 J. Crown, Memorial Sloan-Ketter
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829 Carol L. Epstein, Immunex Resea
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831 Maria Vittoria Gazzola, Unita 1
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833 Mildred S. Hanson, Tumor Immuno
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835 Herbert Kaizer, Rush-Presbyteri
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837 Eric Lepage, Institut d 1 Hemat
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839 Michel Marty, Département de C
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841 J. Myers, Memorial Sloan-Ketter
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843 C. R. Pinkerton, Department of
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845 Rein Sarai, The Johns Hopkins U
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847 J. J. Sotto, C.H.R.U. Orenoble,
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849 Guido Tricot, Department of Med
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851 J.R. Zucali, Department of Medi
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