Overview of ankylosing spondylitis genetics and pathogenesis

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Genetics of AS 1. • Strong HLA-B27 association 94% vs 9.4% controls Odds ratio 171 (95% C.I. 135-218) Brown et al 1996 The prevalence of AS around the world parallels the prevalence of HLA-B27 But B27 alone is not enough………
What causes Ankylosing Spondylitis? • AS major hereditary component >90%. • HLA-B27 contributes about 1/3 of this. • The recurrence risks in different degrees of relatives were: monozygotic (MZ) twins 63% (17/27), first degree relatives 8.2% (441/5390), second degree relatives 1.0% (8/834). Brown 2000
Page 1 and 2: Overview of Ankylosing Spondylitis
Page 3 and 4: Overview 1) Introduction 2) AS gene
Page 5 and 6: Bamboo spine in Ankylosing Spondyli
Page 7 and 8: MRI showing sacroileitis
Page 9 and 10: HLA B27-associated spondyloarthriti
Page 11: Overview 2) AS genetics 3) AS theor
Page 15 and 16: The Times Monday July 11 2011
Page 17 and 18: What does genetics tell us about th
Page 19 and 20: Overview 3) AS theories of pathogen
Page 21 and 22: Ankylosing spondylitis (AS) − The
Page 23 and 24: Molecular structure of HLA B27 a1 a
Page 25 and 26: Different receptors can recognize B
Page 27 and 28: IL17 PE IL17 PE SpA synovial fluid
Page 29 and 30: ?related to HLA-B27
Page 31 and 32: % of Max Abnormal HLA-B27 forms can
Page 33 and 34: ERAP K527R has altered function in
Page 35 and 36: Anti TNF blockade is great in SpA,
Page 37 and 38: The future - • Match phenotype wi
Page 39: Acknowledgements MRC HIU Simon Koll

Overview of ankylosing spondylitis genetics and pathogenesis

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