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Overview of ankylosing spondylitis genetics and pathogenesis

Overview of ankylosing spondylitis genetics and pathogenesis

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Possible role <strong>of</strong> ERAP1 (endoplasmic<br />

reticulum aminopeptidase 1) in AS?<br />

• Trimming <strong>of</strong> “arthritogenic” peptides<br />

• Effect on B27 folding in ER<br />

• Effect on stability <strong>of</strong> B27 on cell surface

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