Overview of ankylosing spondylitis genetics and pathogenesis

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Latest GWAS. Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. • ERAP in B27+ • IL23R, IL-12B (p40) and other genes involved in Th17 responses (eg STAT3) The Australo-Anglo-American Spondyloarthritis Consortium (TASC); the Wellcome Trust Case Control Consortium 2 (WTCCC2), Nat Genet. 2011 Jul 10;43(8):761-767.
What does genetics tell us about the immunopathogenesis of AS? √ AS is highly hereditary √ HLA-B27 critical (and not a linked gene) √ ERAP which is involved in antigen processing. √ Th17 T cells (+ Tumour Necrosis Factor)
Page 1 and 2: Overview of Ankylosing Spondylitis
Page 3 and 4: Overview 1) Introduction 2) AS gene
Page 5 and 6: Bamboo spine in Ankylosing Spondyli
Page 7 and 8: MRI showing sacroileitis
Page 9 and 10: HLA B27-associated spondyloarthriti
Page 11 and 12: Overview 2) AS genetics 3) AS theor
Page 13 and 14: What causes Ankylosing Spondylitis?
Page 15: The Times Monday July 11 2011
Page 19 and 20: Overview 3) AS theories of pathogen
Page 21 and 22: Ankylosing spondylitis (AS) − The
Page 23 and 24: Molecular structure of HLA B27 a1 a
Page 25 and 26: Different receptors can recognize B
Page 27 and 28: IL17 PE IL17 PE SpA synovial fluid
Page 29 and 30: ?related to HLA-B27
Page 31 and 32: % of Max Abnormal HLA-B27 forms can
Page 33 and 34: ERAP K527R has altered function in
Page 35 and 36: Anti TNF blockade is great in SpA,
Page 37 and 38: The future - • Match phenotype wi
Page 39: Acknowledgements MRC HIU Simon Koll

Overview of ankylosing spondylitis genetics and pathogenesis

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