Emerging cytokines and cytokine signalling molecules as ...

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IL-17 stimulates Psoriasis-Keratinocytes to express IL-1F9 (= IL-36) IL-1F6 (fold induction) 4h 24h 4h 24h 4h 24h 4h 24h IL-1F9 (fold induction) IL-36α 100 * * * 15 IL-36 80 60 10 40 IL-1F6 IL-1F9 5 20 0 0 healthy pso healthy pso Muhr et al, Br J Dermatol, 2011
Tenocytes express IL-1F9 Relative IL-1F9 mRNA levels (normalised to U6) 30 20 10 0 NS IL-1alpha 1ng/ml IL-1alpha 10ng/ml IL-1alpha 100ng/ml Dermal fibroblasts Tendon fibroblasts
Page 1 and 2: Emerging cytokines and cytokine sig
Page 3 and 4: Regulation of immune responses pro-
Page 5 and 6: Tissue cells Chemokines: MCP-1 IL-8
Page 7 and 8: McGonagle D, JEADV 2009
Page 9 and 10: Anti-cytokine therapies developed f
Page 11 and 12: IL-12/IL-23p40 Bell et al, Nat Rev
Page 13: IL-17 and TNF act synergistically +
Page 18 and 19: IL-1F9 protein expression in kertin
Page 20 and 21: IL-36 Schulze-Tanzil et al.
Page 22 and 23: Cytokine receptors signal directly
Page 24 and 25: Highly selective kinase inhibitors
Page 26 and 27: Outlook • microRNA • Epigenetic

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