Emerging cytokines and cytokine signalling molecules as ...

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Emerging cytokines and cytokine signalling molecules as ...

Emerging cytokines and cytokine signalling molecules as ...

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• Regulation of Inflammation<br />

• Cytokine network in Psoriatic Inflammation<br />

• Mechanical Stress <strong>and</strong> Cytokines<br />

• Kin<strong>as</strong>e Inhibitors<br />

• Outlook

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• Regulation of Inflammation • Cytokine network in Psoriatic Inflammation • Mechanical Stress <strong>and</strong> Cytokines • Kin<strong>as</strong>e Inhibitors • Outlook

Regulation of immune responses pro-inflammatory „immune response“ trigger Inflammation Resolution time

Page 1: Emerging cytokines and cytokine sig
Page 5 and 6: Tissue cells Chemokines: MCP-1 IL-8
Page 7 and 8: McGonagle D, JEADV 2009
Page 9 and 10: Anti-cytokine therapies developed f
Page 11 and 12: IL-12/IL-23p40 Bell et al, Nat Rev
Page 13: IL-17 and TNF act synergistically +
Page 16 and 17: IL-17 stimulates Psoriasis-Keratino
Page 18 and 19: IL-1F9 protein expression in kertin
Page 20 and 21: IL-36 Schulze-Tanzil et al.
Page 22 and 23: Cytokine receptors signal directly
Page 24 and 25: Highly selective kinase inhibitors
Page 26 and 27: Outlook • microRNA • Epigenetic