BIOGRAPHICAL SKETCH Mark E. Lowe, M.D., Ph.D Professor of ...

B. Selected Peer-Reviewed publications (in chronological order).
1. Lowe ME, Rosenblum JL, and Strauss AW: Cloning and characterization of a cDNA encoding human
pancreatic lipase. J. Biol. Chem. 1989;264:20042-20048.
2. Lowe ME, Rosenblum JL, McEwen P, and Strauss AW: Isolation and characterization of a cDNA
encoding Human Colipase. Biochemistry 1990;29:823-828.
3. Sims HF, and Lowe ME: The human colipase gene: Isolation, chromosomal location, and tissue-specific
expression. Biochemistry 1992;31:7120-7125.
4. Lowe ME: The active-site residues and interfacial binding of human pancreatic lipase. J. Biol. Chem.
1992;267:17069-17073.
5. Kumar BV, Aleman-Gomez JA, Colwell N, Lopez-Candales A, Bosner MS, Spilberg CA, Lowe ME, and
Lange LG: Structure of the human pancreatic cholesterol esterase gene. Biochemistry 1992;31:6077-
6081.
6. Sims HF, Jennens M, and Lowe ME. The human pancreatic lipase gene: structure and conservation of
an Alu sequence in the lipase gene family. Gene 1993;131:281-285.
7. Payne RM, Sims HF, Jennens ML, and Lowe ME. Rat pancreatic lipase and two related proteins:
enzymatic properties and mRNA expression during development. Am. J. Physiol. 994;29:G914-G921.
8. Lowe ME. Human pancreatic procolipase expressed in insect cells: purification and characterization.
Protein expression and Purification 5/6:583-586, 1994.
9. Jennens ML and Lowe ME. A surface loop covering the active site of human pancreatic lipase influences
interfacial activation and lipid binding. J. Biol. Chem. 269(41):25470-25474, 1994.
10. Jennens ML and Lowe ME. The C-terminal domain of human pancreatic lipase is required for stability and
full activity but not colipase reactivation. J. Lip. Res. 36:1029-1030, 1995.
11. Jennens ML and Lowe ME. Rat GP-3 is a pancreatic lipase with kinetic properties that differ from
colipase-dependent pancreatic lipase. J. Lip. Res. 36:2374-2382, 1995.
12. Kullman J, Gisi C and Lowe ME. Dexamethasone regulates expression of pancreatic lipase and two
related proteins in AR42J cells. Am. J. Physiol. 270:G746-G751, 1996.
13. Lowe ME. Mutation of the catalytic site Asp 177 to Glu 177 in human pancreatic lipase produces an active
lipase with decreased conformational stability. Biochem Biophys Acta 1302:177-183, 1996.
14. Andersson L, Carriere F, Lowe ME, Nilsson A and Verger R. Pancreatic lipase related protein 2 but not
classical pancreatic lipase hydrolyzes galactolipids. Biochem Biophys Acta 1302:236-240, 1996.
15. Lowe ME. Colipase stabilizes the lid domain of pancreatic triglyceride lipase. J Biol Chem 272(1):9-12,
1997.
16. Cordle RA and Lowe ME. Purification and characterization of human procolipase expressed in yeast cells.
Protein Expression and Purification 13(1):30-35, 1998.
17. Yang Y and Lowe ME. Human pancreatic triglyceride lipase expressed in yeast cells: Purification and
characterization. Protein Expression and Purification. 13(1):36-40, 1998.
18. Cordle R and Lowe ME. The hydrophobic surface of colipase influences lipase activity at an oil-water
interface. J. Lip. Res. 1998;39:1759-1767.
19. Winzell-Sorhede M, Lowe ME and Erlanson-Albertsson, C. Rat gastric procolipase: Sequence, expression
and secretion during high-fat feeding. Gastroenterology. 1998;115:1179-1185.
20. Lowe ME, Kaplan MH, Jackson-Grusby L, D'Agostino D and Grusby MJ. Decreased neonatal dietary fat
absorption and T cell cytotoxicity in pancreatic lipase-related protein 2-deficient mice. J. Biol. Chem.
1998;273(47):31215-31221.
21. Roussel A, Yang Y, Ferrato F, Verger R, Cambillau C and Lowe ME. Structure and activity of rat
pancreatic lipase-related protein 2. J. Biol. Chem. 1998;273(48):32121-32128.
22. Yang Y and Lowe ME. The open lid mediates pancreatic lipase function. J. Lipid Res. 2000; 41:48-57.
23. Yang Y, Sanchez D, Figarella C, and Lowe ME. Discoordinate expression of pancreatic lipase and two
related proteins in the human fetal pancreas. Pediatr. Res. 2000;47:184-188.
24. Crandall WV and Lowe ME. Colipase residues Glu 64 and Arg 65 are essential for normal lipase mediated
fat digestion in the presence of bile salt micelles. J. Biol. Chem. 2001;275:12505-12512.
25. Bauer VW, Squire TL, Lowe ME, and Andrews MT. Novel expression of pancreatic triacylglycerol in white
adipose tissues confers low-temperature lipolysis in a hibernating animal. Am. J. Physiol. 2001;
281:R1186-R1192.