improved facial surface sebum and pore appearance - P&G Beauty ...
improved facial surface sebum and pore appearance - P&G Beauty ...
improved facial surface sebum and pore appearance - P&G Beauty ...
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Introduction<br />
• Niacinamide (Vitamin B3) is utilized in numerous topical cosmetic<br />
products to provide beneficial effects for a wide array of common skin<br />
problems such as those associated with aging <strong>and</strong> photoaging, e.g.,<br />
dryness, red blotchiness, hyperpigmentation, texture problems <strong>and</strong> fine<br />
lines/wrinkles (1-4). A general mechanism for niacinamide is as a<br />
precursor to the important cofactors nicotinamide adenine dinucleotide<br />
(NAD), its phosphate derivative (NADP), <strong>and</strong> their reduced forms<br />
(NADH <strong>and</strong> NADPH).<br />
• Dehydroacetic acid <strong>and</strong> its more water soluble salts such as Sodium<br />
Dehydroacetate (SDA) have been used as antimicrobial agents in a<br />
range of cosmetic formulations (5).<br />
• A screening program was conducted with a wide range of compounds<br />
<strong>and</strong> natural extracts to identify potential lipogenesis inhibitors. Two<br />
compounds identified were Niacinamide <strong>and</strong> SDA.<br />
• This report presents the in vitro responses as well as cosmetic benefits<br />
of Niacinamide <strong>and</strong> SDA-containing moisturizers for <strong>sebum</strong>-related<br />
endpoints.
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