et al - Organization for Human Brain Mapping
et al - Organization for Human Brain Mapping
et al - Organization for Human Brain Mapping
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Using fMRI to d<strong>et</strong>ect conscious awareness<br />
Adrian M. Owen<br />
MRC Cognition and <strong>Brain</strong> Sciences Unit, Cambridge, UK<br />
http://web.me.com/adrian.owen
“The limits of consciousness are hard to define satisfactorily<br />
and we can only infer the self-awareness of others by their<br />
appearance and their acts”<br />
Plum and Posner, The Diagnosis of Stupor and Coma, 1966
Davis <strong>et</strong> <strong>al</strong>., PNAS, 2007<br />
Coleman <strong>et</strong> <strong>al</strong>., BRAIN, 2007
Speech-specific responses are common in disorders of consciousness<br />
Coleman <strong>et</strong> <strong>al</strong>., <strong>Brain</strong>, 2009
Speech-specific responses in VS and MCS<br />
Coleman <strong>et</strong> <strong>al</strong>., <strong>Brain</strong>, 2009
“….Imagine playing tennis”<br />
Boly <strong>et</strong> <strong>al</strong>., Neuroimage, 2007; Owen <strong>et</strong> <strong>al</strong>., Science, 2006
Instructions:<br />
“If you want to say „yes‟, imagine playing tennis”<br />
“Is your husband<br />
c<strong>al</strong>led Charlie?”<br />
“Is your husband<br />
c<strong>al</strong>led Terry?”<br />
“Is your dog<br />
c<strong>al</strong>led Terry?”<br />
“Is your dog<br />
c<strong>al</strong>led Charlie?”<br />
Owen & Coleman, Nature Reviews Neurosciences, 2008
Owen <strong>et</strong> <strong>al</strong>., Science, 313, 1402, 2006
Owen <strong>et</strong> <strong>al</strong>., Science, 313, 1402, 2006
Monti/Vanhaudenhuyse <strong>et</strong> <strong>al</strong>., NEJM, 2010
Monti/Vanhaudenhuyse <strong>et</strong> <strong>al</strong>., NEJM, 2010
Monti/Vanhaudenhuyse <strong>et</strong> <strong>al</strong>., NEJM, 2010
“The limits of consciousness are hard to define satisfactorily<br />
and we can only infer the self-awareness of others by their<br />
appearance and their acts”<br />
Plum and Posner, The Diagnosis of Stupor and Coma, 1966
Thanks…<br />
Wolfson <strong>Brain</strong> Imaging Centre, Cambridge<br />
Martin Coleman<br />
David Menon<br />
John Pickard<br />
Anthony Abs<strong>al</strong>om<br />
Ram Adapa<br />
University of Liege<br />
MRC Cognition and <strong>Brain</strong> Sciences Unit<br />
Tristan Bekinschtein<br />
Damian Cruse<br />
Rhodri Cusack<br />
Matt Davis<br />
Di<strong>et</strong>s Jolles<br />
Martin Monti<br />
B<strong>et</strong>h Parkin<br />
Audrey Vanhaudenhuyse<br />
Melanie Boly<br />
Steven Laureys
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