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DO letterhead - Departments of Pathology and Laboratory Medicine ...

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

BERKELEY • DAVIS • IRVINE • LOS ANGELES • RIVERSIDE • SAN DIEGO • SAN FRANCISCO

SANTA BARBARA • SANTA CRUZ

University of California San Francisco Prepared: 07/01/10

CURRICULUM VITAE

Name:

Position:

Han S. Lee

Assistant Professor of Clinical Pathology

University of California San Francisco, Department of Pathology

School of Medicine

Address:

Veterans Affairs Medical Center

Department of Pathology

4150 Clement St – 113B

Building 2, Room 355A

San Francisco, CA 94121

Voice: (415) 221-4810 (x2615)

FAX: (415) 379-5643

email: han.lee@ucsfmedctr.org

EDUCATION:

1987-91 McGill University, Montreal, Canada B.Sc. Honors, Biochemistry

1991-94 McGill University, Montreal, Canada M.Sc. Biochemistry

(Nahum Sonenberg, Ph.D.)

1997-2005 University of Cincinnati Medical School M.D.-Ph.D. Neuroscience

(Michael Lehman, Ph.D.)

2005-07 University of California, San Francisco Resident Anatomic Pathology

2007-09 University of California, San Francisco Fellow Neuropathology

2009-10 University of California, San Francisco Fellow Surgical Pathology

LICENSES, CERTIFICATION:

2007 Medical licensure, California

2009 Diplomate, Anatomic Pathology and Neuropathology, American Board of Pathology

PRINCIPAL POSITIONS HELD:

2010-present University of California, San Francisco Assistant Professor Anatomic Pathology


Han Lee

OTHER POSITIONS HELD CONCURRENTLY:

2010-present VA Medical Center, San Francisco Staff Pathologist Anatomic Pathology

HONORS AND AWARDS:

1992-93 FCAR award. Masters studentship. McGill University.

1998-99 Class awards for Microanatomy, Physiology and Pharmacology courses. University of

Cincinnati medical school. Top 3 students.

2001-03 Ryan Fellowship. PhD studentship. University of Cincinnati, Neuroscience Program.

2005 Alpha Omega Alpha.

2005 David Confer Memorial Award. Department of Pathology and Laboratory Medicine.

University of Cincinnati medical school.

2008 Resident teaching award as Neuropathology fellow. University of California San Francisco.

2010 Resident teaching award as Surgical Pathology fellow. University of California San Francisco.

KEYWORDS/AREAS OF INTEREST:

Surgical pathology, neuropathology, skeletal muscle, neurodegeneration, neuro-oncology.

PROFESSIONAL ACTIVITIES

CLINICAL

Attending physician, Anatomic Pathology, UCSF: 2/8 FTE in Neuropathology division since July 2010,

with contributions to surgical neuropathology, night-call, autopsy and muscle/nerve biopsy services.

Staff physician, Anatomic Pathology, VAMC: 6/8 FTE in Anatomic Pathology department since July 2010,

with contributions to surgical pathology, cytopathology, neuropathology and autopsy services.

PROFESSIONAL ORGANIZATIONS

Membership:

2008-present, American Association of Neuropathologists.

INVITED PRESENTATIONS

REGIONAL AND OTHER INVITED PRESENTATIONS

2007 Internal Medicine Morbidity and Mortality Conference, UCSF. Fungal infection.

2007-08 Neurology Clinical-Pathologic Correlation Conferences, UCSF. Mitochondrial myopathy,

CADASIL, transverse myelitis.

2008 Pediatric Neurology Case Conference, UCSF. Medulloblastoma.

2008 Neurology departmental teaching conference, UCSF. CNS tumors.

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Han Lee

PEER REVIEWED PUBLICATIONS:

1. Goyer C, Lee HS, Malo D, Sonenberg N. Isolation of a yeast gene encoding a protein homologous to the

human Tat-binding protein TBP-1. DNA Cell Biol. 1992 11:579-85.

2. Meerovitch K, Svitkin YV, Lee HS, Lejbkowicz F, Kenan DJ, Chan EK, Agol VI, Keene JD,

Sonenberg N. La autoantigen enhances and corrects aberrant translation of poliovirus RNA in

reticulocyte lysate. J Virol. 1993 67:3798-807.

3. Goyer C, Altmann M, Lee HS, Blanc A, Deshmukh M, Woolford JL Jr, Trachsel H, Sonenberg N.

TIF4631 and TIF4632: two yeast genes encoding the high-molecular-weight subunits of the cap-binding

protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence and

carry out an essential function. Mol Cell Biol. 1993 13:4860-74.

4. Svitkin YV, Meerovitch K, Lee HS, Dholakia JN, Kenan DJ, Agol VI, Sonenberg N. Internal translation

initiation on poliovirus RNA: further characterization of La function in poliovirus translation in vitro. J

Virol. 1994 68:1544-50.

5. Lavoie C, Tam R, Clark M, Lee H, Sonenberg N, Lasko P. Suppression of a temperature-sensitive cdc33

mutation of yeast by a multicopy plasmid expressing a Drosophila ribosomal protein. J Biol Chem. 1994

269:14625-30.

6. Mader S, Lee H, Pause A, Sonenberg N. The translation initiation factor eIF-4E binds to a common motif

shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins. Mol

Cell Biol. 1995 15:4990-7.

7. Craig AW, Svitkin YV, Lee HS, Belsham GJ, Sonenberg N. The La autoantigen contains a dimerization

domain that is essential for enhancing translation. Mol Cell Biol. 1997 17:163-9.

8. McCuaig KA, Lee HS, Clarke JC, Assar H, Horsford J, White JH. Parathyroid hormone/parathyroid

hormone related peptide receptor gene transcripts are expressed from tissue-specific and ubiquitous

promoters. Nucleic Acids Res. 1995 23(11):1948-55.

9. Aumais JP, Lee HS, DeGannes C, Horsford J, White JH. Function of directly repeated half-sites as

response elements for steroid hormone receptors. J Biol Chem. 1996 271:12568-77.

10. Lee HS, Aumais J, White JH. Hormone-dependent transactivation by estrogen receptor chimeras that do

not interact with hsp90. Evidence for transcriptional repressors. J Biol Chem. 1996 271:25727-30.

11. Amizuka N, Lee HS, Kwan MY, Arazani A, Warshawsky H, Hendy GN, Ozawa H, White JH, Goltzman

D. Cell-specific expression of the parathyroid hormone (PTH)/PTH-related peptide receptor gene in

kidney from kidney-specific and ubiquitous promoters. Endocrinology. 1997 138:469-81.

12. Bettoun JD, Minagawa M, Kwan MY, Lee HS, Yasuda T, Hendy GN, Goltzman D, White JH. Cloning

and characterization of the promoter regions of the human parathyroid hormone (PTH)/PTH-related

peptide receptor gene: analysis of deoxyribonucleic acid from normal subjects and patients with

pseudohypoparathyroidism type 1b. J Clin Endocrinol Metab. 1997 82:1031-40.

13. Aumais JP*, Lee HS*, Lin R, White JH. Selective interaction of hsp90 with an estrogen receptor ligandbinding

domain containing a point mutation. J Biol Chem. 1997 272:12229-35. *equal authorship

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Han Lee

14. Eng FC, Lee HS, Ferrara J, Willson TM, White JH. Probing the structure and function of the estrogen

receptor ligand binding domain by analysis of mutants with altered transactivation characteristics. Mol

Cell Biol. 1997 17:4644-53.

15. Fernandes I, Bastien Y, Wai T, Nygard K, Lin R, Cormier O, Lee HS, Eng F, Bertos NR, Pelletier N,

Mader S, Han VK, Yang XJ, White JH. Ligand-dependent nuclear receptor corepressor LCoR functions

by histone deacetylase-dependent and -independent mechanisms. Mol Cell. 2003 11:139-50.

16. Slane JM, Lee HS, Vorhees CV, Zhang J, Xu M. DNA fragmentation factor 45 deficient mice exhibit

enhanced spatial learning and memory compared to wild-type control mice. Brain Res. 2000 867:70-9.

17. Zhang J, Lee H, Lou DW, Bovin GP, Xu M. Lack of obvious 50 kilobase pair DNA fragments in DNA

fragmentation factor 45-deficient thymocytes upon activation of apoptosis. Biochem Biophys Res

Commun. 2000 274:225-9.

18. Zhang J, Lee H, Agarwala A, Wen Lou D, Xu M. DNA fragmentation factor 45 mutant mice exhibit

resistance to kainic acid-induced neuronal cell death. Biochem Biophys Res Commun. 2001 285:1143-9.

19. Lee HS, Nelms JL, Nguyen M, Silver R, Lehman MN. The eye is necessary for a circadian rhythm in the

suprachiasmatic nucleus. Nat Neurosci 2003 6:111-2.

20. Tong Y, Guo H, Brewer JM, Lee H, Lehman MN, Bittman EL. Expression of haPer1 and haBmal1 in

Syrian hamsters: heterogeneity of transcripts and oscillations in the periphery. J Biol Rhythms. 2004

19:113-25.

21. Dominguez JM, Balfour ME, Lee HS, Brown JL, Davis BA and Coolen LM. Mating activates NMDA

receptors in the medial preoptic area of male rats. Behav Neurosci 2007 121: 1023-31.

22. Ramachandran R, Lee HS, Matthews B, Shatzel A, Tihan T. Intradural extramedullary leptomeningeal

hemangioblastomatosis and paraneoplastic limbic encephalitis diagnosed at autopsy: an unlikely pair.

Arch Pathol Lab Med 2008 132:104-108.

23. Irodenko V, Lee HS, DeArmond S, Layzer R. Adult nemaline myopathy with trabecular muscle fibers.

Muscle Nerv 2009 39:871-875.

24. Ho EL, Josephson SA, Lee HS, Smith WS. Cerebrovascular complications of methamphetamine abuse.

Neurocrit Care 2009 10:295-305.

25. Layzer, R, Lee HS, Margeta M. Dermatomyositis with inclusion body pathology. Muscle Nerv 2009

40:469-471.

26. Silkiss RZ, Lee HS, Gills VL. HAART therapy associated ptosis in patients with human

immunodeficiency virus. Arch Ophthalmol 2009 127: 345-346.

27. Su X, Kells AP, Huang EJ, Lee HS, Hadaczek P, Beyer J, Bringas J, Pivirotto P, Penticuff J, Eberling J,

Federoff HJ, Forsayeth J, Bankiewicz KS. Safety evaluation of AAV2-GDNF gene transfer into the

dopaminergic nigrostriatal pathway in aged and Parkinsoniam rhesus monkeys. Hum Gene Ther 2009

20:1627-1640.

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Han Lee

28. Ambrose JB, Bennett HD, Lee HS, Josephson SA. Cerebral vasculopathy after 4-bromo-

2,5dimethoxyphenethylamine ingestion. Neurologist 2010 16:199-202.

NON-PEER REVIEWED PUBLICATIONS AND OTHER CREATIVE ACTIVITIES:

Review Article

1. Lee HS, Billings HJ, Lehman MN. The suprachiasmatic nucleus: a clock of multiple components. J

Biol Rhythms. 2003 18:435-49.

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