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DO letterhead - Departments of Pathology and Laboratory Medicine ...
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UNIVERSITY OF CALIFORNIA, SAN FRANCISCO<br />
BERKELEY • DAVIS • IRVINE • LOS ANGELES • RIVERSIDE • SAN DIEGO • SAN FRANCISCO<br />
SANTA BARBARA • SANTA CRUZ<br />
University <strong>of</strong> California San Francisco Prepared: 07/01/10<br />
CURRICULUM VITAE<br />
Name:<br />
Position:<br />
Han S. Lee<br />
Assistant Pr<strong>of</strong>essor <strong>of</strong> Clinical <strong>Pathology</strong><br />
University <strong>of</strong> California San Francisco, Department <strong>of</strong> <strong>Pathology</strong><br />
School <strong>of</strong> <strong>Medicine</strong><br />
Address:<br />
Veterans Affairs Medical Center<br />
Department <strong>of</strong> <strong>Pathology</strong><br />
4150 Clement St – 113B<br />
Building 2, Room 355A<br />
San Francisco, CA 94121<br />
Voice: (415) 221-4810 (x2615)<br />
FAX: (415) 379-5643<br />
email: han.lee@ucsfmedctr.org<br />
EDUCATION:<br />
1987-91 McGill University, Montreal, Canada B.Sc. Honors, Biochemistry<br />
1991-94 McGill University, Montreal, Canada M.Sc. Biochemistry<br />
(Nahum Sonenberg, Ph.D.)<br />
1997-2005 University <strong>of</strong> Cincinnati Medical School M.D.-Ph.D. Neuroscience<br />
(Michael Lehman, Ph.D.)<br />
2005-07 University <strong>of</strong> California, San Francisco Resident Anatomic <strong>Pathology</strong><br />
2007-09 University <strong>of</strong> California, San Francisco Fellow Neuropathology<br />
2009-10 University <strong>of</strong> California, San Francisco Fellow Surgical <strong>Pathology</strong><br />
LICENSES, CERTIFICATION:<br />
2007 Medical licensure, California<br />
2009 Diplomate, Anatomic <strong>Pathology</strong> <strong>and</strong> Neuropathology, American Board <strong>of</strong> <strong>Pathology</strong><br />
PRINCIPAL POSITIONS HELD:<br />
2010-present University <strong>of</strong> California, San Francisco Assistant Pr<strong>of</strong>essor Anatomic <strong>Pathology</strong>
Han Lee<br />
OTHER POSITIONS HELD CONCURRENTLY:<br />
2010-present VA Medical Center, San Francisco Staff Pathologist Anatomic <strong>Pathology</strong><br />
HONORS AND AWARDS:<br />
1992-93 FCAR award. Masters studentship. McGill University.<br />
1998-99 Class awards for Microanatomy, Physiology <strong>and</strong> Pharmacology courses. University <strong>of</strong><br />
Cincinnati medical school. Top 3 students.<br />
2001-03 Ryan Fellowship. PhD studentship. University <strong>of</strong> Cincinnati, Neuroscience Program.<br />
2005 Alpha Omega Alpha.<br />
2005 David Confer Memorial Award. Department <strong>of</strong> <strong>Pathology</strong> <strong>and</strong> <strong>Laboratory</strong> <strong>Medicine</strong>.<br />
University <strong>of</strong> Cincinnati medical school.<br />
2008 Resident teaching award as Neuropathology fellow. University <strong>of</strong> California San Francisco.<br />
2010 Resident teaching award as Surgical <strong>Pathology</strong> fellow. University <strong>of</strong> California San Francisco.<br />
KEYWORDS/AREAS OF INTEREST:<br />
Surgical pathology, neuropathology, skeletal muscle, neurodegeneration, neuro-oncology.<br />
PROFESSIONAL ACTIVITIES<br />
CLINICAL<br />
Attending physician, Anatomic <strong>Pathology</strong>, UCSF: 2/8 FTE in Neuropathology division since July 2010,<br />
with contributions to surgical neuropathology, night-call, autopsy <strong>and</strong> muscle/nerve biopsy services.<br />
Staff physician, Anatomic <strong>Pathology</strong>, VAMC: 6/8 FTE in Anatomic <strong>Pathology</strong> department since July 2010,<br />
with contributions to surgical pathology, cytopathology, neuropathology <strong>and</strong> autopsy services.<br />
PROFESSIONAL ORGANIZATIONS<br />
Membership:<br />
2008-present, American Association <strong>of</strong> Neuropathologists.<br />
INVITED PRESENTATIONS<br />
REGIONAL AND OTHER INVITED PRESENTATIONS<br />
2007 Internal <strong>Medicine</strong> Morbidity <strong>and</strong> Mortality Conference, UCSF. Fungal infection.<br />
2007-08 Neurology Clinical-Pathologic Correlation Conferences, UCSF. Mitochondrial myopathy,<br />
CADASIL, transverse myelitis.<br />
2008 Pediatric Neurology Case Conference, UCSF. Medulloblastoma.<br />
2008 Neurology departmental teaching conference, UCSF. CNS tumors.<br />
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Han Lee<br />
PEER REVIEWED PUBLICATIONS:<br />
1. Goyer C, Lee HS, Malo D, Sonenberg N. Isolation <strong>of</strong> a yeast gene encoding a protein homologous to the<br />
human Tat-binding protein TBP-1. DNA Cell Biol. 1992 11:579-85.<br />
2. Meerovitch K, Svitkin YV, Lee HS, Lejbkowicz F, Kenan DJ, Chan EK, Agol VI, Keene JD,<br />
Sonenberg N. La autoantigen enhances <strong>and</strong> corrects aberrant translation <strong>of</strong> poliovirus RNA in<br />
reticulocyte lysate. J Virol. 1993 67:3798-807.<br />
3. Goyer C, Altmann M, Lee HS, Blanc A, Deshmukh M, Woolford JL Jr, Trachsel H, Sonenberg N.<br />
TIF4631 <strong>and</strong> TIF4632: two yeast genes encoding the high-molecular-weight subunits <strong>of</strong> the cap-binding<br />
protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence <strong>and</strong><br />
carry out an essential function. Mol Cell Biol. 1993 13:4860-74.<br />
4. Svitkin YV, Meerovitch K, Lee HS, Dholakia JN, Kenan DJ, Agol VI, Sonenberg N. Internal translation<br />
initiation on poliovirus RNA: further characterization <strong>of</strong> La function in poliovirus translation in vitro. J<br />
Virol. 1994 68:1544-50.<br />
5. Lavoie C, Tam R, Clark M, Lee H, Sonenberg N, Lasko P. Suppression <strong>of</strong> a temperature-sensitive cdc33<br />
mutation <strong>of</strong> yeast by a multicopy plasmid expressing a Drosophila ribosomal protein. J Biol Chem. 1994<br />
269:14625-30.<br />
6. Mader S, Lee H, Pause A, Sonenberg N. The translation initiation factor eIF-4E binds to a common motif<br />
shared by the translation factor eIF-4 gamma <strong>and</strong> the translational repressors 4E-binding proteins. Mol<br />
Cell Biol. 1995 15:4990-7.<br />
7. Craig AW, Svitkin YV, Lee HS, Belsham GJ, Sonenberg N. The La autoantigen contains a dimerization<br />
domain that is essential for enhancing translation. Mol Cell Biol. 1997 17:163-9.<br />
8. McCuaig KA, Lee HS, Clarke JC, Assar H, Horsford J, White JH. Parathyroid hormone/parathyroid<br />
hormone related peptide receptor gene transcripts are expressed from tissue-specific <strong>and</strong> ubiquitous<br />
promoters. Nucleic Acids Res. 1995 23(11):1948-55.<br />
9. Aumais JP, Lee HS, DeGannes C, Horsford J, White JH. Function <strong>of</strong> directly repeated half-sites as<br />
response elements for steroid hormone receptors. J Biol Chem. 1996 271:12568-77.<br />
10. Lee HS, Aumais J, White JH. Hormone-dependent transactivation by estrogen receptor chimeras that do<br />
not interact with hsp90. Evidence for transcriptional repressors. J Biol Chem. 1996 271:25727-30.<br />
11. Amizuka N, Lee HS, Kwan MY, Arazani A, Warshawsky H, Hendy GN, Ozawa H, White JH, Goltzman<br />
D. Cell-specific expression <strong>of</strong> the parathyroid hormone (PTH)/PTH-related peptide receptor gene in<br />
kidney from kidney-specific <strong>and</strong> ubiquitous promoters. Endocrinology. 1997 138:469-81.<br />
12. Bettoun JD, Minagawa M, Kwan MY, Lee HS, Yasuda T, Hendy GN, Goltzman D, White JH. Cloning<br />
<strong>and</strong> characterization <strong>of</strong> the promoter regions <strong>of</strong> the human parathyroid hormone (PTH)/PTH-related<br />
peptide receptor gene: analysis <strong>of</strong> deoxyribonucleic acid from normal subjects <strong>and</strong> patients with<br />
pseudohypoparathyroidism type 1b. J Clin Endocrinol Metab. 1997 82:1031-40.<br />
13. Aumais JP*, Lee HS*, Lin R, White JH. Selective interaction <strong>of</strong> hsp90 with an estrogen receptor lig<strong>and</strong>binding<br />
domain containing a point mutation. J Biol Chem. 1997 272:12229-35. *equal authorship<br />
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Han Lee<br />
14. Eng FC, Lee HS, Ferrara J, Willson TM, White JH. Probing the structure <strong>and</strong> function <strong>of</strong> the estrogen<br />
receptor lig<strong>and</strong> binding domain by analysis <strong>of</strong> mutants with altered transactivation characteristics. Mol<br />
Cell Biol. 1997 17:4644-53.<br />
15. Fern<strong>and</strong>es I, Bastien Y, Wai T, Nygard K, Lin R, Cormier O, Lee HS, Eng F, Bertos NR, Pelletier N,<br />
Mader S, Han VK, Yang XJ, White JH. Lig<strong>and</strong>-dependent nuclear receptor corepressor LCoR functions<br />
by histone deacetylase-dependent <strong>and</strong> -independent mechanisms. Mol Cell. 2003 11:139-50.<br />
16. Slane JM, Lee HS, Vorhees CV, Zhang J, Xu M. DNA fragmentation factor 45 deficient mice exhibit<br />
enhanced spatial learning <strong>and</strong> memory compared to wild-type control mice. Brain Res. 2000 867:70-9.<br />
17. Zhang J, Lee H, Lou DW, Bovin GP, Xu M. Lack <strong>of</strong> obvious 50 kilobase pair DNA fragments in DNA<br />
fragmentation factor 45-deficient thymocytes upon activation <strong>of</strong> apoptosis. Biochem Biophys Res<br />
Commun. 2000 274:225-9.<br />
18. Zhang J, Lee H, Agarwala A, Wen Lou D, Xu M. DNA fragmentation factor 45 mutant mice exhibit<br />
resistance to kainic acid-induced neuronal cell death. Biochem Biophys Res Commun. 2001 285:1143-9.<br />
19. Lee HS, Nelms JL, Nguyen M, Silver R, Lehman MN. The eye is necessary for a circadian rhythm in the<br />
suprachiasmatic nucleus. Nat Neurosci 2003 6:111-2.<br />
20. Tong Y, Guo H, Brewer JM, Lee H, Lehman MN, Bittman EL. Expression <strong>of</strong> haPer1 <strong>and</strong> haBmal1 in<br />
Syrian hamsters: heterogeneity <strong>of</strong> transcripts <strong>and</strong> oscillations in the periphery. J Biol Rhythms. 2004<br />
19:113-25.<br />
21. Dominguez JM, Balfour ME, Lee HS, Brown JL, Davis BA <strong>and</strong> Coolen LM. Mating activates NMDA<br />
receptors in the medial preoptic area <strong>of</strong> male rats. Behav Neurosci 2007 121: 1023-31.<br />
22. Ramach<strong>and</strong>ran R, Lee HS, Matthews B, Shatzel A, Tihan T. Intradural extramedullary leptomeningeal<br />
hemangioblastomatosis <strong>and</strong> paraneoplastic limbic encephalitis diagnosed at autopsy: an unlikely pair.<br />
Arch Pathol Lab Med 2008 132:104-108.<br />
23. Irodenko V, Lee HS, DeArmond S, Layzer R. Adult nemaline myopathy with trabecular muscle fibers.<br />
Muscle Nerv 2009 39:871-875.<br />
24. Ho EL, Josephson SA, Lee HS, Smith WS. Cerebrovascular complications <strong>of</strong> methamphetamine abuse.<br />
Neurocrit Care 2009 10:295-305.<br />
25. Layzer, R, Lee HS, Margeta M. Dermatomyositis with inclusion body pathology. Muscle Nerv 2009<br />
40:469-471.<br />
26. Silkiss RZ, Lee HS, Gills VL. HAART therapy associated ptosis in patients with human<br />
immunodeficiency virus. Arch Ophthalmol 2009 127: 345-346.<br />
27. Su X, Kells AP, Huang EJ, Lee HS, Hadaczek P, Beyer J, Bringas J, Pivirotto P, Penticuff J, Eberling J,<br />
Feder<strong>of</strong>f HJ, Forsayeth J, Bankiewicz KS. Safety evaluation <strong>of</strong> AAV2-GDNF gene transfer into the<br />
dopaminergic nigrostriatal pathway in aged <strong>and</strong> Parkinsoniam rhesus monkeys. Hum Gene Ther 2009<br />
20:1627-1640.<br />
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Han Lee<br />
28. Ambrose JB, Bennett HD, Lee HS, Josephson SA. Cerebral vasculopathy after 4-bromo-<br />
2,5dimethoxyphenethylamine ingestion. Neurologist 2010 16:199-202.<br />
NON-PEER REVIEWED PUBLICATIONS AND OTHER CREATIVE ACTIVITIES:<br />
Review Article<br />
1. Lee HS, Billings HJ, Lehman MN. The suprachiasmatic nucleus: a clock <strong>of</strong> multiple components. J<br />
Biol Rhythms. 2003 18:435-49.<br />
5