in rabies - libdoc.who.int - World Health Organization

CONTENTS
Chapter 32 Cell-culture vaccines for veternary use (P. Reculard)
Substrates for the production of seed virus and vaccne
Preparation of the vaccines
Manufacturing requirements for cell-culture rabies vaccines
and recommendations for their use
Planning a facility for the production of rabies vaccine for
veterinary use
References
Chapter 33 Modified live-virus rabies vaccines for oral immunization of
carnivores (J Riancou & F-X. Meslin)
Modified live-virus vaccines
Guidelines for assessing the safety and efficacy of MLV
vaccines
References
Section D. Genetically engineered vaccines
Chapter 34 General considerations in the use of recombinant rabies
vaccines for oral iminunzation of wildlife (C. E. Rupprecht, C. A
Hanlon & H. Koprowsk~)
References
Chapter 35 Expressron of rabies proteins using prokaryotc and
eukaryotic expression systems (B. Diefzschold)
Prokaryotic expression systems
Eukaryotic expression systenis
References
Part V. Vaccine safety and tests for potency and antigen quantification
Chapter 36 General considerations in testing the safety and potency of
rabies vaccines (P. Sizaret)
References
Chapter 37 The NIH test for potency (L. A. Wilbur & M. F. A. Aubert)
Standard test
Modified NIH test
References
Annex Preparation of Challenge V~rus Standard (CVS)
diluent, pH 7.6
Chapter 38 Habel test for potency (K. Habel)
Standard test
Modifled Habel test
Annex Calculating 50% end-point dilutions by the method
of Reed & Muench
Chapter 39 Guinea-pig potency test for chicken-embryo vaccine
(H. Kopro wski)
Immunization orocedure