Comparative Effectiveness of New Oral Anticoagulants for ...
Comparative Effectiveness of New Oral Anticoagulants for ...
Comparative Effectiveness of New Oral Anticoagulants for ...
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<strong>Comparative</strong> <strong>Effectiveness</strong> <strong>of</strong> <strong>New</strong> <strong>Oral</strong> <strong>Anticoagulants</strong><br />
<strong>for</strong> Thromboprophylaxis<br />
Evidence-based Synthesis Program<br />
TABLE OF CONTENTS<br />
ExEcutivE Summary<br />
Background......................................................................................................................................................1<br />
Methods ...........................................................................................................................................................2<br />
Data Synthesis .................................................................................................................................................2<br />
Rating the Body <strong>of</strong> Evidence...........................................................................................................................2<br />
Peer Review.....................................................................................................................................................3<br />
Results .............................................................................................................................................................3<br />
Recommendations <strong>for</strong> Future Research...........................................................................................................9<br />
Conclusion.......................................................................................................................................................9<br />
Abbreviations Table.......................................................................................................................................10<br />
introduction<br />
Pharmacological Treatment Options <strong>for</strong> VTE Thromboprophylaxis ............................................................11<br />
mEthodS<br />
Topic Development........................................................................................................................................13<br />
Analytic Framework......................................................................................................................................13<br />
Search Strategy..............................................................................................................................................14<br />
Study Selection..............................................................................................................................................14<br />
Data Abstraction ............................................................................................................................................15<br />
Quality Assessment .......................................................................................................................................16<br />
Data Synthesis ...............................................................................................................................................16<br />
Rating the Body <strong>of</strong> Evidence.........................................................................................................................17<br />
Peer Review...................................................................................................................................................18<br />
rESultS<br />
Literature Search ...........................................................................................................................................19<br />
Study Characteristics.....................................................................................................................................20<br />
Participant Characteristics.............................................................................................................................22<br />
KQ 1. <strong>Comparative</strong> effectiveness <strong>of</strong> newer oral anticoagulants and standard drug classes..........................23<br />
KQ 2. <strong>Comparative</strong> effects <strong>of</strong> combined pharmacological and mechanical modalities................................27<br />
KQ 3. <strong>Comparative</strong> efficacy <strong>of</strong> newer oral anticoagulants............................................................................28<br />
Summary and diScuSSion<br />
Summary <strong>of</strong> Evidence by Key Question .......................................................................................................30<br />
Clinical and Policy Implications ...................................................................................................................34<br />
Applicability..................................................................................................................................................36<br />
Strengths and Limitations..............................................................................................................................36<br />
Recommendations <strong>for</strong> Future Research.........................................................................................................36<br />
Conclusion.....................................................................................................................................................37<br />
rEfErEncES ..............................................................................................................................................................38<br />
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