Comparative Effectiveness of New Oral Anticoagulants for ...

Comparative Effectiveness of New Oral Anticoagulants
for Thromboprophylaxis
Evidence-based Synthesis Program
appEndix a
appEndix B
appEndix c
appEndix d
appEndix E
appEndix f
SEarch StratEgiES.............................................................................................................42
ExcludEd StudiES...............................................................................................................43
SamplE data aBStraction form..................................................................................46
critEria uSEd in Quality aSSESSmEnt of SyStEmatic rEviEwS.......................49
pEEr rEviEw commEntS ..................................................................................................52
gloSSary ...............................................................................................................................56
figurES
Figure 1.
Figure 2.
Analytic framework for the comparative effectiveness of newer oral anticoagulants..............13
Literature flow diagram.............................................................................................................19
taBlES
Table 1.
Table 2.
Table 3.
Table 4.
Table 5.
Table 6.
Table 7.
Table 8.
Table 9.
Table 10.
Summary of the strength of evidence for KQ 1 ..........................................................................5
Summary of the strength of evidence for KQ 3 ..........................................................................8
Evidence gaps and future research..............................................................................................9
Summary of inclusion and exclusion criteria............................................................................15
Characteristics of included systematic reviews.........................................................................21
Characteristics of patient samples.............................................................................................22
Summary of the strength of evidence for KQ 1 ........................................................................31
Summary of the strength of evidence for KQ 3 ........................................................................33
U.S. guideline recommendations related to specific thromboprophylaxis strategies................35
Evidence gaps and future research............................................................................................37
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