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Biomedical Engineering - Technische Universiteit Eindhoven

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Profile<br />

Education<br />

Research<br />

There is an endless demand in modern healthcare for technologies to improve the diagnosis,<br />

treatment and prevention of health problems. To meet this demand, the <strong>Eindhoven</strong> University<br />

of Technology (TU/e) focuses a great deal of its research and education on health technologies<br />

and has a department devoted entirely to this socially vital area: <strong>Biomedical</strong> <strong>Engineering</strong>.<br />

<strong>Biomedical</strong> engineers improve human health through cross-disciplinary activities that integrate<br />

the engineering sciences with the biomedical sciences and clinical practice.<br />

<strong>Biomedical</strong> <strong>Engineering</strong> (BME) is a familiar discipline around the world, but there are many<br />

different types of programs. In 1997 TU/e was one of the first universities to introduce an integrated<br />

five-year BME program leading to a master’s degree. From the outset, the curriculum integrates<br />

the natural sciences and engineering disciplines with cell biology and pathophysiology.<br />

It is also designed to meld seamlessly with the research in our own department.<br />

Research ranges from regenerative medicine to image anaylsis to molecular<br />

engineering. The research is performed in eight specialized research groups that<br />

cooperate in several mutual projects, such as developing an artificial human<br />

kidney and designing personalized medicines.<br />

Synergy of education and research<br />

The Department of <strong>Biomedical</strong> <strong>Engineering</strong> provides<br />

high-quality academic education and cutting-edge research.<br />

• Education<br />

One bachelor’s track, <strong>Biomedical</strong> <strong>Engineering</strong>, and two<br />

master’s tracks, <strong>Biomedical</strong> <strong>Engineering</strong> and Medical<br />

<strong>Engineering</strong>.<br />

• Research<br />

performed in eight specialized research groups and covers<br />

everything from regenerative medicine to image analysis<br />

to molecular engineering.<br />

Contact between the 300 undergraduate students, 200<br />

graduate students and 180 researchers is open and personal.<br />

This allows the students to have good interaction with the<br />

scientists and medical specialists. As a result, our students<br />

are capable of performing and coordinating basic and applied<br />

scientific research in the field of biomedical engineering from<br />

a very early stage in their careers. The close collaboration<br />

between our researchers also fosters cooperation between<br />

research groups in numerous shared projects, such as the<br />

development of an artificial human kidney and the design of<br />

personalized medicines.<br />

“To discover why these diseases develop is a<br />

key driver for me.” Prof.dr.ir. Luc Brunsveld, Chemical Biology /<br />

Department of <strong>Biomedical</strong> <strong>Engineering</strong><br />

Partners in health<br />

The Department of <strong>Biomedical</strong> <strong>Engineering</strong> collaborates<br />

closely with other health-oriented departments at TU/e, other<br />

universities, academic hospitals and industrial partners. Much<br />

of this collaboration occurs through international contacts in<br />

countries such as China, the U.S.A., Australia and European<br />

countries.<br />

Bachelor’s program<br />

The three-year bachelor’s program focuses on research and<br />

development and offers a broad range of knowledge and skills.<br />

Students take courses on mathematics, physics, chemistry,<br />

electrical engineering, mechanical engineering, computer<br />

science, physiology and biology. From day one, they work<br />

together in teams on state-of-the-art biomedical problems,<br />

so that they also develop such valuable skills as cooperation,<br />

communication and reporting. The students are guided by<br />

graduate students, post-docs and academic staff, including<br />

professors, in these projects.<br />

Besides the fixed parts of the bachelor’s program, students<br />

choose their own track. Many students choose to broaden<br />

their scope by studying another field of research, perhaps<br />

at another university or even abroad. Popular tracks are<br />

Medicine and Management Sciences.<br />

Master programs<br />

When it comes time to move on to a master’s degree program,<br />

there are plenty of appropriate ones to choose from at other<br />

universities. Students who have taken specific medical<br />

elective courses are eligible to the admission procedure of<br />

the Selective Utrecht Medical Master (SUMMA) program at<br />

Utrecht University, the Arts-Klinisch Onderzoeker program<br />

(AKO) of the University at Maastricht, and the Medical Masters<br />

programs in Groningen (ZIG) and Amsterdam. However, most<br />

students decide to follow a master program that belongs to<br />

the Life Sciences and <strong>Engineering</strong> graduate program. This TU/e<br />

graduate program includes the master program <strong>Biomedical</strong><br />

<strong>Engineering</strong> and the master program Medical <strong>Engineering</strong>.<br />

<strong>Biomedical</strong> <strong>Engineering</strong><br />

The Master in <strong>Biomedical</strong><br />

<strong>Engineering</strong> is strongly<br />

research focused and aims to<br />

develop general solutions for<br />

a patient group. <strong>Biomedical</strong><br />

engineers specialize in one<br />

particular field relevant to<br />

clinical problems.<br />

Medical <strong>Engineering</strong><br />

The Master in Medical<br />

<strong>Engineering</strong> aims to<br />

integrate advanced medical<br />

technologies into clinical<br />

practice. Medical engineers<br />

develop solutions to clinical<br />

problems. They solve patient<br />

specific problems, through<br />

models and technologies.<br />

At the start of both master programs, students become a<br />

member of one of our eight research groups. They design their<br />

own personal curriculum in cooperation with a professor. Most<br />

students go abroad for a three-to-four-month internship as part<br />

of the program, with popular destinations being the U.S.A. and<br />

Australia. In fact, the study materials for both the bachelor’s<br />

and master programs are in English, so all students are wellprepared<br />

for an international career.<br />

Careers for a biomedical engineer<br />

Most graduates will start working as a researcher after<br />

finishing their master <strong>Biomedical</strong> <strong>Engineering</strong> or Medical<br />

<strong>Engineering</strong>. But some of them become: developer, project<br />

manager, lecturer, salesman, advisor...<br />

The sectors and companies that graduates (after their master)<br />

work in can be found in the diagram below.<br />

• Universities (PhD students) (30%)<br />

• (Academic) Hospitals (22%)<br />

• Development of medical<br />

products (16%)<br />

• Pharmaceutical companies (10%)<br />

• Small companies (10%)<br />

• National research institutes (5%)<br />

• Organisation and finances (5%)<br />

• Other (2%)<br />

As there is always more to learn, graduates may continue<br />

studying. They often choose for an education program at<br />

the School for medical Physics and <strong>Engineering</strong> to become a<br />

clinical physicist, a qualified medical engineer or qualified<br />

medical Informatics professional. Or they choose a four year<br />

research program to become a PhD.<br />

“In my biomedical engineering study, I learned<br />

to discuss with all kind of engineers at a high<br />

level and to quickly identify the innovative<br />

aspects of inventions. This boosted my career<br />

as a consultant and enables me to efficiently<br />

translate technical ideas into commercial<br />

products.” Jasper Levink, Business development<br />

consultant, ttopstart<br />

Soft Tissue Biomechanics and<br />

<strong>Engineering</strong><br />

Prof.dr.ir. Frank Baaijens &<br />

Prof. dr. Carlijn Bouten<br />

Through experimentation and numerical<br />

modeling, we study how living tissues<br />

adapt to mechanical loading. We apply<br />

the knowledge of tissue proliferation<br />

and differentiation thus obtained to<br />

biomedical problems such as prosthesis<br />

design, pressure ulcers and the<br />

engineering of living tissues and organs<br />

(e.g., heart valves and intervertebral<br />

discs).<br />

Cardiovascular Biomechanics<br />

Prof.dr.ir. Frans van de Vosse<br />

We develop experimental and<br />

computational models of the cardiovascular<br />

system for the purpose of<br />

supporting medical decision making<br />

in clinical practice. The models can be<br />

used in the development of methods<br />

for quantitative measurements (e.g.,<br />

pressure, flow, and tissue deformation)<br />

and to predict the outcome of medical<br />

intervention (e.g., surgery and<br />

medication).<br />

Orthopaedic Biomechanics<br />

Prof.dr. Keita Ito<br />

We combine engineering and biology<br />

to expand our understanding of the<br />

biomechanical function of musculoskeletal<br />

tissues, as well as their adaptive<br />

developmental and physiological nature.<br />

Our investigations of degenerative<br />

diseases and regenerative treatment<br />

strategies target the three tissues bone,<br />

articular cartilage and intervertebral disc.<br />

<strong>Biomedical</strong> Image Analysis<br />

Prof.dr.ir. Bart ter Haar Romenij<br />

We develop new robust image analysis<br />

algorithms for computer-aided diagnosis<br />

and interactive 3D visualization to help<br />

in extracting quantitative information<br />

from medical images. We apply these<br />

techniques to practical clinical problems,<br />

with an emphasis on the cardiovascular<br />

system (3D deformation, ablation,<br />

4D flow, interventions) and the brain<br />

(tractography, surgery navigation).<br />

Biomodeling & Bioinformatics<br />

Prof.dr. Peter Hilbers<br />

We investigate and apply molecular<br />

modeling methods, machine learning,<br />

systems biology and parameter<br />

estimation techniques to construct<br />

computational models. With these<br />

models, we improve our qualitative and<br />

quantitative knowledge of biomedical<br />

processes and structures, such as<br />

biomembranes, protein interactions<br />

and complex biochemical networks, and<br />

diseases, such as metabolic syndrome<br />

and diabetes mellitus.<br />

Chemical Biology<br />

Prof.dr.ir. Luc Brunsveld<br />

We apply novel chemistry techniques to<br />

biology to enhance our understanding<br />

of diseases on the molecular level and<br />

develop new or personalized drugs.<br />

Our targets of interest are studies of<br />

the nuclear receptors that play a role<br />

in cancer and the visualization and<br />

assembly processes of proteins, such as<br />

disease relevant membrane proteins.<br />

<strong>Biomedical</strong> Chemistry<br />

Prof.dr. Bert Meijer<br />

Our aim is to develop new molecular<br />

tools and biomaterials for biomedical<br />

research using supramolecular<br />

interactions. We create new materials<br />

for tissue engineering (e.g., an artificial<br />

kidney), novel peptide-based scaffolds<br />

for drug delivery, and proteins with<br />

attractive biomedical properties for<br />

molecular imaging. We focus on artificial<br />

structures that are indistinguishable<br />

from their natural counterparts.<br />

<strong>Biomedical</strong> NMR<br />

Prof.dr. Klaas Nicolay<br />

We develop non-invasive imaging<br />

techniques to improve the diagnosis and<br />

treatment of cardiovascular diseases,<br />

metabolic disorders and cancer. Our<br />

research focuses on expanding the<br />

capabilities of Magnetic Resonance<br />

Imaging (MRI) and Spectroscopy (MRS).<br />

Following initial validation in preclinical<br />

studies, we aim to translate promising<br />

methods into clinical use.

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