Local Tolerability of AN2728 Topical Ointment, 2% in ... - Anacor

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AN2728: A Novel Boron-based Topical PDE-4 Inhibitor AN2728 is a novel oxaborole agent in development as a topical treatment for inflammatory skin disorders AN2728 inhibits phosphodiesterase-4 and key pro-inflammatory cytokines Boron is essential for its anti-inflammatory activity AN2728 has been studied in 14 clinical trials AN2728 has successfully completed Phase 2 for the indication of psoriasis and is being explored for the treatment of atopic dermatitis 2
Psoriasis: Plaque-type and Inverse Patterns Psoriasis vulgaris or plaque-type psoriasis, the most common form of psoriasis, is characterized by thick plaques primarily on the elbows, knees, umbilicus, genital area, lower back, and scalp A significant minority of psoriasis patients have an inverse pattern of psoriasis, involving the skin folds, recesses, genitalia, and other thin-skinned areas generally considered to be more easily irritated The use of many existing topical psoriasis treatments are commonly avoided in sensitive or intertriginous areas due to the increased potential for both topical and systemic side effects This study was conducted to examine the local tolerability of AN2728 Topical Ointment, 2% compared to vehicle in sensitive skin areas of healthy volunteers 3
Page 1: Poster #5890 Local Tolerability of
Page 5 and 6: Grading of Local Tolerability Sympt
Page 7 and 8: Local Tolerability: Frequency of No
Page 9: Discussion and Overall Conclusions

Local Tolerability of AN2728 Topical Ointment, 2% in ... - Anacor

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